Krecmerova, Marcela

Cerny, Miloslav; Budesinsky, Milos; Krecmerova, Marcela; Holy, Antonin, UTILIZATION OF 1,6-ANHYDROHEXOSES FOR THE PREPARATION OF SOME ALIPHATIC ADENOSINE ANALOGS. Collect. Czech. Chem. Commun. 1989, 54(10), 2753 - 2766.

Krecmerova, Marcela; Holy, Antonin; Hrebabecky, Hubert, SYNTHESIS OF 5'-O-PHOSPHONOMETHYL DERIVATIVES OF PYRIMIDINE 2'-DEOXYNUCLEOSIDES. Collect. Czech. Chem. Commun. 1990, 55(10), 2521 - 2536.

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena; Hrebabecky, Hubert, PREPARATION OF PURINE 2'-DEOXY-5'-O-PHOSPHONOMETHYLNUCLEOSIDES AND 2'-DEOXY-3'-O-PHOSPHONOMETHYLNUCLEOSIDES. Collect. Czech. Chem. Commun. 1993, 58(2), 421 - 434, 10.1135/cccc19930421 .

Krecmerova, Marcela; Holy, Antonin, PREPARATION OF PHOSPHONOMETHYL ETHERS DERIVED FROM 2-PHENYLETHANOL AND ITS AMINO DERIVATIVES. Collect. Czech. Chem. Commun. 1995, 60(4), 659 - 669, 10.1135/cccc19950659 .

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena, SYNTHESIS OF 3-(4-PYRIDINYL)-, 3-(2-CHLORO-4-PYRIDINYL)- AND 3-(2-AMINO-4-PYRIDINYL)PROPOXYMETHANEPHOSPHONIC ACID. Collect. Czech. Chem. Commun. 1995, 60(4), 670 - 680, 10.1135/cccc19950670 .

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena; Hrebabecky, Hubert, Synthesis of 5-phenyl-2(1H)-pyrimidinone nucleosides. Collect. Czech. Chem. Commun. 1996, 61(3), 458 - 477, 10.1135/cccc19960458 .

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena; Hrebabecky, Hubert, 2′,3′-dideoxy- and 3′-azido-2′,3′-dideoxynucleosides of 5-phenyl-2(1H)-pyrimidinone. Preparation of 2′,3′-dideoxypentofuranoses. Collect. Czech. Chem. Commun. 1996, 61(3), 478 - 488, 10.1135/cccc19960478 .

Krecmerova, Marcela; Holy, Antonin; Hrebabecky, Hubert, Preparation of 5-benzyluracil and 5-benzylcytosine nucleosides as potential inhibitors of uridine phosphorylase. Collect. Czech. Chem. Commun. 1996, 61(4), 627 - 644, 10.1135/cccc19960627 .

Krecmerova, Marcela; Holy, Antonin; Hrebabecky, Hubert, Synthesis of 5-phenylcytosine nucleoside derivatives. Collect. Czech. Chem. Commun. 1996, 61(4), 645 - 655, 10.1135/cccc19960645 .

Krecmerova, Marcela; Holy, Antonin; Votruba, Ivan; Hrebabecky, Hubert, Inhibitory potency of 5-benzyluracil, 5-phenylcytosine and 5- phenylpyrimidin-2-one nucleosides against uridine phosphorylase from mouse leukemic L1210 cells. Nucleosides and Nucleotides 1999, 18(11-12), 2551 - 2564.

Budesinsky, Milos; Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena, Synthesis of optically active N-alkyl derivatives of (R)-3-(adenin-9-yl)-2-hydroxypropanoic acid and related compounds. Collect. Czech. Chem. Commun. 2003, 68(5), 931 - 950, 10.1135/cccc20030931 .

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena, Synthesis of N- and N-[2-hydroxy-3- (phosphonomethoxy)-propyl] derivatives of N-substituted adenines, 2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 2004, 69(10), 1889 - 1913, 10.1135/cccc20041889 .

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena, Preparation of C-5 substituted cidofovir derivatives. Collect. Czech. Chem. Commun. 2006, 71(4), 579 - 594, 10.1135/cccc20060579 .

Krecmerova, Marcela; Holy, Antonin; Zidek, Zdenek; Kmonickova, Eva; Potmesil, Petr, Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N-substituted derivatives. Eur. J. Pharmacol. 2006, 540(1-3), 191 - 199, 10.1016/j.ejphar.2006.04.018 .

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Naesens, Lieve; Piskala, Alois; Neyts, Johan, Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2- (phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry 2007, 50(5), 1069 - 1077, 10.1021/jm061281+ .

Krecmerova, Marcela; Holy, Antonin; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Lebeau, Ilya, Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Antimicrobial Agents and Chemotherapy 2007, 51(6), 2268 - 2273, 10.1128/AAC.01422-06 .

Krecmerova, Marcela; Holy, Antonin; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Duraffour, Sophie; Van Den Oord, Joost; De Vos, Rita; Crance, Jean-Marc; Garin, Daniel, Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. Antimicrobial Agents and Chemotherapy 2007, 51(12), 4410 - 4419, 10.1128/AAC.00838-07 .

Krecmerova, Marcela; Holy, Antonin; Renders, Marleen; Emmerechts, Gert; Rozenski, Jef; Herdewijn, Piet, Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase. Angewandte Chemie - International Edition 2007, 46(14), 2501 - 2504, 10.1002/anie.200603435 .

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Pohl, Radek; Naesens, Lieve; Neyts, Johan, Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5- azacytosine: Synthesis and antiviral activity. Journal of Medicinal Chemistry 2007, 50(23), 5765 - 5772, 10.1021/jm0707166 .

Krecmerova, Marcela; Holy, Antonin; Votruba, Ivan; Tloust'Ova, Eva; Hajek, Miroslav, Alpha anomer of 5-aza-2′-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells. Biochemical Pharmacology 2008, 75(4), 965 - 972, 10.1016/j.bcp.2007.10.018 .

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena, Pyrimidine acyclic nucleotide analogues with aromatic substituents in C-5 position. Collect. Czech. Chem. Commun. 2007, 72(7), 927 - 951, 10.1135/cccc20070927 .

Krecmerova, Marcela; Holy, Antonin; Dracinsky, Martin, Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy. Bioorganic and Medicinal Chemistry 2008, 16(14), 6778 - 6782, 10.1016/j.bmc.2008.05.058 .

Krecmerova, Marcela; Holy, Antonin; Votruba, Ivan; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Naesens, Lieve; Neyts, Johan, Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. Biochemical Pharmacology 2008, 76(8), 997 - 1005, 10.1016/j.bcp.2008.08.009 .

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena, Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position. Bioorganic and Medicinal Chemistry 2010, 18(1), 387 - 395, 10.1016/j.bmc.2009.10.044 .

Krecmerova, Marcela; Holy, Antonin; Dracinsky, Martin; Masojidkova, Milena; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Pohl, Radek; Cihlar, Tomas; Naesens, Lieve; Pomeisl, Karel; Neyts, Johan; Tichy, Tomas; Brehova, Petra; Laflamme, Genevieve; Hui, Hon, Synthesis of ester prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl] -2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. Journal of Medicinal Chemistry 2010, 53(19), 6825 - 6837, 10.1021/jm901828c .

Krecmerova, Marcela; Holy, Antonin; Dracinsky, Martin; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Tichy, Tomas, New prodrugs of Adefovir and Cidofovir. Bioorganic and Medicinal Chemistry 2011, 19(11), 3527 - 3539, 10.1016/j.bmc.2011.04.016 .

Krecmerova, Marcela; Holy, Antonin; Cesnek, Michal; Hockova, Dana; Naesens, Lieve; Keough, Dianne T.; De Jersey, John; Guddat, Luke W.; Brereton, Ian M.; Winzor, Donald J., Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy. Molecular and Biochemical Parasitology 2010, 173(2), 165 - 169, 10.1016/j.molbiopara.2010.05.018 .

Krecmerova, Marcela; Holy, Antonin; Dracinsky, Martin; Hockova, Dana; Keough, Dianne T.; Guddat, Luke W., Synthesis of purine N-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorganic and Medicinal Chemistry 2012, 20(3), 1222 - 1230, 10.1016/j.bmc.2011.12.034 .

Krecmerova, Marcela; Holy, Antonin; Jansa, Petr; Otmar, Miroslav; Baszczynski, Ondrej; Blazek, Jiri; Kaiser, Martin Maxmilian; Drancinsky, Martin; Kralova, Blanka, An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli. Bioorganic and Medicinal Chemistry 2012, 20(9), 3111 - 3118, 10.1016/j.bmc.2012.02.062 .

Krecmerova, Marcela; Holy, Antonin; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Gammon, Don B.; Fiten, Pierre; Opdenakker, Ghislain; Evans, David H., Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs. Journal of Virology 2008, 82(24), 12520 - 12534, 10.1128/JVI.01528-08 .

Krecmerova, Marcela; Holy, Antonin; Renders, Marleen; Herdewijn, Piet; Lievrouw, Roel, Enzymatic polymerization of phosphonate nucleosides.. Chembiochem : a European journal of chemical biology 2008, 9(17), 2883 - 2888, 10.1002/cbic.200800494 .

Krecmerova, Marcela; Dracinsky, Martin; Jansa, Petr; Janeba, Zlatko; Neyts, Johan; Kasicka, Vaclav; Stepan, George; Sazelova, Petra; Auwerx, Joeri; Kiss, Eleonora; Goris, Nesya, 9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: Optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro. Bioorganic and Medicinal Chemistry 2013, 21(5), 1199 - 1208, 10.1016/j.bmc.2012.12.044 .

Krecmerova, Marcela; Rosemeyer, Helmut; Seela, Frank, 9-(2'-Deoxy-β-D-xylofuranosyl)adenine Building Blocks for Solid-Phase Synthesis and Properties of Oligo(2'-deoxy-xylonucleotides). Helv. Chim. Acta 1991, 74(8), 2054 - 2067, 10.1002/hlca.19910740840 .

Krecmerova, Marcela; Dracinsky, Martin; Votruba, Ivan; Otmar, Miroslav; Marak, David, 8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase. Bioorganic and Medicinal Chemistry Letters 2011, 21(2), 652 - 654, 10.1016/j.bmcl.2010.12.027 .

Krecmerova, Marcela; Pohl, Radek; Horska, Kvetoslava; Pomeisl, Karel; Blazek, Jiri, Syntheses of 1-[2-(phosphonomethoxy)alkyl]thymine monophosphates and an evaluation of their inhibitory activity toward human thymidine phosphorylase. Nucleosides, Nucleotides and Nucleic Acids 2012, 31(3), 159 - 171, 10.1080/15257770.2011.648361 .

Krecmerova, Marcela; Dracinsky, Martin; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Tichy, Tomas, Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety. Eur. J. Med. Chem. 2012, 55, 307 - 314,8, 10.1016/j.ejmech.2012.07.027 .

Krecmerova, Marcela; Andrei, Graciela; Snoeck, Robert; Duraffour, Sophie; Crance, Jean-Marc; Garin, Daniel; Topalis, Dimitri, Mutations conferring resistance to viral DNA polymerase inhibitors in camelpox virus give different drug-susceptibility profiles in vaccinia virus. Journal of Virology 2012, 86(13), 7310 - 7325, 10.1128/JVI.00355-12 .

Krecmerova, Marcela; Blazek, Jiri; Brabcova, Jana; Janska, Lucie; Zarevucka, Marie, Lipases as tools in the synthesis of prodrugs from racemic 9-(2,3-dihydroxypropyl)adenine. Molecules 2012, 17(12), 13813 - 13824, 10.3390/molecules171213813 .

Krecmerova, Marcela; Hockova, Dana; Vrbkova, Silvie; Keough, Dianne T.; De Jersey, John; Guddat, Luke W.; Rejman, Dominik; Spacek, Petr; Eng, Wai Soon; Jans, Harmen; West, Nicholas P.; Naesens, Lieve M.J., Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: Potential for new antibacterial agents. Journal of Medicinal Chemistry 2013, 56(17), 6967 - 6984, 10.1021/jm400779n .

Krecmerova, Marcela; Andrei, Graciela; Snoeck, Robert; Naesens, Lieve; Duraffour, Sophie; Coen, Natacha; Oord, Joost Van den, Evaluation of novel acyclic nucleoside phosphonates against human and animal gammaherpesviruses revealed an altered metabolism of cyclic prodrugs upon epstein-barr virus reactivation in P3HR-1 cells. Journal of Virology 2013, 87(22), 12422 - 12432, 10.1128/JVI.02231-13 .

Krecmerova, Marcela; Vavrova, Katerina; Hrabalek, Alexandr; Skolova, Barbora; Roh, Jaroslav; Diblikova, Denisa; Kopecna, Monika, Transdermal delivery and cutaneous targeting of antivirals using a penetration enhancer and lysolipid prodrugs. Pharmaceutical Research 2014, 31(4), 1071 - 1081, 10. .

Krecmerova, Marcela; Masojidkova, Milena; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Pohl, Radek, N-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: Chemistry and antiviral activity. Bioorganic and Medicinal Chemistry 2014, 22(10), 2896 - 2906, 10.1016/j.bmc.2014.03.031 .

Krecmerova, Marcela; Holy, Antonin; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Naesens, Lieve; Piskala, Alois; Neyts, Johan, AZACYTOSINE DERIVATIVES USEFUL AS ANTIVIRAL AGENTS, WO2007/65231, 2007.