Holy, Antonin
Articles
Cerny, Miloslav;
Budesinsky, Milos;
Krecmerova, Marcela;
Holy, Antonin, UTILIZATION OF 1,6-ANHYDROHEXOSES FOR THE PREPARATION OF SOME ALIPHATIC ADENOSINE ANALOGS. Collect. Czech. Chem. Commun. 1989, 54(10), 2753 - 2766.
Holy, Antonin;
Dvorakova, Hana;
Dvorak, Dalimil, Coupling of 6-chloropurines with organocuprates derived from Grignard reagents: A convenient route to sec and tert 6-alkylpurines. Tetrahedron Letters 1996, 37(8), 1285 - 1288, 10.1016/0040-4039(95)02375-5 
.
.
Holy, Antonin;
Dvorak, Dalimil;
Wagner, Roman, New Application of the Stille Coupling in the Synthesis of 5-Substituted Uracils. Collect. Czech. Chem. Commun. 1996, 61, S118 - S119.
Holy, Antonin;
Dvorakova, Hana;
Dvorak, Dalimil, Synthesis of acyclic nucleotide analogues derived from 6-(sec-OR tert-alkyl)purines via coupling of 6-chloropurine derivatives with organocuprates. Collect. Czech. Chem. Commun. 1998, 63(12), 2065 - 2074.
Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena, SYNTHESIS OF ACYCLIC NUCLEOTIDE ANALOGUES DERIVED FROM 2-(AMINOMETHYL)ADENINE AND 2-(AMINOMETHYL)HYPOXANTHINE. Collect. Czech. Chem. Commun. 1995, 60(5), 875 - 882, 10.1135/cccc19950875 .
.
Holy, Antonin;
Hocek, Michal, A FACILE SYNTHESIS OF 6-CYANOPURINE BASES. Collect. Czech. Chem. Commun. 1995, 60(8), 1386 - 1389, 10.1135/cccc19951386 .
.
Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik, Synthesis and antiviral activity of acyclic nucleotide analogues derived from 6-(aminomethyl)purines and purine-6-carboxamidines. Collect. Czech. Chem. Commun. 1996, 61(10), 1525 - 1537, 10.1135/cccc19961525 .
.
Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena, Synthesis of acyclic nucleotide analogues derived from N-substituted 6-(1-aminoethyl)purines via 6-acetylpurine derivatives. Tetrahedron 1997, 53(6), 2291 - 2302, 10.1016/S0040-4020(96)01130-1 .
.
Holy, Antonin;
Hocek, Michal, Acyclic Nucleotide Analogues Derived from 6-(1-Aminoalkyl)purines. Collect. Czech. Chem. Commun. 1996, 61, S55 - S58.
Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena, Synthesis of acyclic nucleotide analogues derived from 6-hetarylpurines via cross-coupling reactions of 9-[2-(diethoxyphosphonylmethoxy)ethyl]-6-iodopurine with hetaryl organometallic reagents. Collect. Czech. Chem. Commun. 1997, 62(1), 136 - 146.
Holy, Antonin;
Hocek, Michal, Perfluoroalkylation of 6-iodopurines by trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(perfluoroalkyl)purine bases, nucleosides and acyclic nucleotide analogues. Collect. Czech. Chem. Commun. 1999, 64(2), 229 - 241.
Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: Application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids. Journal of Medicinal Chemistry 2000, 43(9), 1817 - 1825, 10.1021/jm991167+ .
.
Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-β-D-erythro-pentofuranosyl)-, 9-(5-deoxy-β-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines. Collect. Czech. Chem. Commun. 2000, 65(11), 1683 - 1697.
Holy, Antonin;
Hocek, Michal;
Cesnek, Michal, Synthesis of acyclic nucleotide analogues derived from 2-amino-6-C-substituted purines via cross-coupling reactions of 2-amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-halopurines with diverse organometallic reagents. Collect. Czech. Chem. Commun. 2000, 65(8), 1357 - 1373.
Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl-and 6-benzylpurine ribonucleosides. Collect. Czech. Chem. Commun. 2001, 66(3), 483 - 499, 10.1135/cccc20010483 .
.
Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal, Cytostatic 6-arylpurine nucleosides IV. Synthesis of 2-substituted 6-phenylpurine ribonucleosides. Collect. Czech. Chem. Commun. 2002, 67(3), 325 - 335, 10.1135/cccc20020325 .
.
Holy, Antonin;
Dvorakova, Hana;
Rosenberg, Ivan, SYNTHESIS OF N-(2-(2-PHOSPHONYLETHOXY)ETHYL) DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1990, 55(3), 809 - 818.
Holy, Antonin;
Hrebabecky, Hubert;
Clercq, Erik de, SYNTHESIS OF 3'-AZIDO-2',3'-DIDEOXY-6-METHYLURIDINE, 2',3'-DIDEOXY-6-METHYLURIDINE AND 2',3'-DIDEOXY-2',3'-DIDEHYDRO-6-METHYLURIDINE. Collect. Czech. Chem. Commun. 1990, 55(7), 1801 - 1811.
Holy, Antonin;
Horska, Kveta;
Cvekl, Ales;
Rosenberger, Ivan;
Sebesta, Karel, DNA-DEPENDENT RNA POLYMERASE MEDIATED FORMATION OF METHYLPHOSPHONYL INTERNUCLEOTIDE LINKAGE. Collect. Czech. Chem. Commun. 1990, 55(8), 2100 - 2109.
Krecmerova, Marcela;
Holy, Antonin;
Hrebabecky, Hubert, SYNTHESIS OF 5'-O-PHOSPHONOMETHYL DERIVATIVES OF PYRIMIDINE 2'-DEOXYNUCLEOSIDES. Collect. Czech. Chem. Commun. 1990, 55(10), 2521 - 2536.
Holy, Antonin;
Votruba, Ivan;
Rosenberg, Ivan;
Sediva, Katarina, PURINE NUCLEOSIDE PHOSPHORYLASE: ISOLATION AND CHARACTERIZATION. Collect. Czech. Chem. Commun. 1990, 55(12), 2987 - 2999.
Holy, Antonin;
Pischel, Helmut;
Wagner, Guenther, SYNTHESIS OF CONJUGATES OF 5'-O-CARBOXYMETHYL-5-HALOGENO-2'-DEOXYURIDINES AND 5'-O-CARBOXYMETHYL-5-HALOGENOURIDINES WITH PROTEINS. Collect. Czech. Chem. Commun. 1980, 45(2), 606 - 610.
Holy, Antonin;
Kavunenko, Antonina P., RIBONUCLEASE A CATALYZED PREPARATIVE SYNTHESIS OF DINUCLEOSIDE MONOPHOSPHATES CONTAINING URIDINE ANALOGUES. Collect. Czech. Chem. Commun. 1980, 45(2), 611 - 616.
Holy, Antonin;
Votruba, Ivan;
Clercq, Erik de;
Koenig, Joachim;
Vesely, Jiri;
Cech, Dieter, 5'-O-ALKYL-5-FLUOROURIDINES: SYNTHESIS AND BIOLOGICAL ACTIVITY. Collect. Czech. Chem. Commun. 1987, 52(6), 1589 - 1608.
Holy, Antonin;
Votruba, Ivan;
Rosenberg, Ivan, AFFINITY CHROMATOGRAPHY OF RAT LIVER S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. Collect. Czech. Chem. Commun. 1983, 48(9), 2549 - 2557.
Holy, Antonin;
Votruba, Ivan;
Vesely, Jiri;
Merta, Ales, S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE FROM MOUSE LEUKEMIC CELLS: ISOLATION AND PROPERTIES. Collect. Czech. Chem. Commun. 1983, 48(9), 2701 - 2708.
Holy, Antonin;
Pischel, Helmut;
Wagner, Guenther, PREPARATION OF CONJUGATES OF URIDINE WITH PROTEINS BY THE IMIDO ESTER CONDENSATION METHOD. Collect. Czech. Chem. Commun. 1981, 46(4), 933 - 940.
Holy, Antonin, PREPARATION AND SYNTHETIC UTILIZATION OF 3-(ADENIN-9-YL)-2-HYDROXYALKANOIC ACIDS AND THEIR DERIVATIVES. Collect. Czech. Chem. Commun. 1984, 49(9), 2148 - 2166.
Holy, Antonin;
Rosenberg, Ivan, SYNTHESIS OF ISOMERIC AND ENANTIOMERIC O-PHOSPHONYLMETHYL DERIVATIVES OF 9-(2,3-DIHYDROXYPROPYL)ADENINE. Collect. Czech. Chem. Commun. 1987, 52(11), 2775 - 2791.
Holy, Antonin;
Rosenberg, Ivan, SYNTHESIS OF POTENTIAL PRODRUGS AND METABOLITES OF 9-(S)-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROPYL)ADENINE. Collect. Czech. Chem. Commun. 1987, 52(11), 2792 - 2800.
Holy, Antonin;
Rosenberg, Ivan, SYNTHESIS OF 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE AND RELATED COMPOUNDS. Collect. Czech. Chem. Commun. 1987, 52(11), 2801 - 2809.
Holy, Antonin;
Votruba, Ivan;
Rosenberg, Ivan;
Nishizawa, Masahiko, THE EFFECT OF PHOSPHONYLMETHYL ANALOGS OF RIBONUCLEOSIDE 5'-DIPHOSPHATES ON (E. coli) POLYNUCLEOTIDE PHOSPHORYLASE CATALYZED REACTIONS. Collect. Czech. Chem. Commun. 1987, 52(12), 3042 - 3057.
Holy, Antonin;
Votruba, Ivan;
Sebestova, Ladislava, S-ADENOSINE-L-HOMOCYSTEINE HYDROLASE FROM Nicotiana tabacum L.: ISOLATION AND PROPERTIES. Collect. Czech. Chem. Commun. 1984, 49(6), 1543 - 1551.
Holy, Antonin;
Rosenberg, Ivan, PREPARATION OF 5'-O-PHOSPHONYLMETHYL ANALOGUES OF NUCLEOSIDE-5'-PHOSPHATES, 5'-DIPHOSPHATES AND 5'-TRIPHOSPHATES. Collect. Czech. Chem. Commun. 1982, 47(12), 3447 - 3463.
Holy, Antonin;
Rosenberg, Ivan;
Vesely, Jiri, INHIBITION BY CTP AND UTP ANALOGUES OF URIDINE KINASE FROM MOUSE LEUKEMIC CELLS. Collect. Czech. Chem. Commun. 1982, 47(12), 3464 - 3469.
Holy, Antonin;
Votruba, Ivan;
Merta, Ales;
Kohoutova, Jitka, 9-(AMINOALKYL)-8-HYDROXYADENINES: PREPARATION, MECHANISM OF FORMATION AND USE IN AFFINITY CHROMATOGRAPHY OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. Collect. Czech. Chem. Commun. 1986, 51(2), 459 - 477.
Holy, Antonin;
Rosenberg, Ivan;
Horska, Kveta;
Sebesta, Karel, 5'-O-DIPHOSPHORYLPHOSPHONYLMETHYLRIBONUCLEOSIDES-A NEW GROUP OF DNA-DEPENDENT RNA POLYMERASE INHIBITORS. Collect. Czech. Chem. Commun. 1983, 48(5), 1352 - 1357.
Holy, Antonin;
Rosenberg, Ivan;
Vesely, Jiri, DONOR ACTIVITY OF 5'-O-PHOSPHONYLMETHYL ANALOGUES OF ATP AND GTP IN THE PHOSPHORYLATION OF URIDINE CATALYZED BY URIDINE KINASE FROM MOUSE LEUKEMIC CELLS. Collect. Czech. Chem. Commun. 1983, 48(6), 1783 - 1787.
Holy, Antonin;
Pischel, Helmut;
Wagner, Guenther;
Vesely, Jiri;
Cech, Dieter, HYDROPHILIC 1-(CARBOXYMETHYL)-5-FLUOROURACIL AMIDES: PREPARATION AND CYTOSTATIC ACTIVITY. Collect. Czech. Chem. Commun. 1987, 52(8), 2061 - 2069.
Holy, Antonin;
Rosenberg, Ivan, SYNTHESIS OF PHOSPHONYLMETHYL ANALOGUES OF DIRIBONUCLEOSIDE MONOPHOSPHATES CONTAINING MODIFIED INTERNUCLEOTIDE BOND. Collect. Czech. Chem. Commun. 1987, 52(10), 2572 - 2588.
Holy, Antonin;
Kois, Pavol, SYNTHESIS OF 2'(3')-PHOSPHATES AND 2'(3')-PHOSPHOROTHIOATES OF 5'-O-CARBOXYMETHYLINOSINE AND RELATED COMPOUNDS. Collect. Czech. Chem. Commun. 1980, 45(10), 2817 - 2829.
Holy, Antonin;
Kois, Pavol, PREPARATION OF DERIVATIVES OF INOSINE 5'-PHOSPHOROTHIOATE FOR USE IN AFFINITY CHROMATOGRAPHY. Collect. Czech. Chem. Commun. 1980, 45(10), 2830 - 2838.
Holy, Antonin;
Rosenberg, Ivan;
Kois, Pavol, AFFINITY CHROMATOGRAPHY OF GUANYLORIBONUCLEASE FROM Streptomyces aureofaciens. Collect. Czech. Chem. Commun. 1980, 45(10), 2839 - 2846.
Holy, Antonin;
Votruba, Ivan, INHIBITION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE BY THE ALIPHATIC NUCLEOSIDE ANALOGUE - 9-(S)-(2,3-DIHYDROXYPROPYL)ADENINE. Collect. Czech. Chem. Commun. 1980, 45(11), 3039 - 3044.
Holy, Antonin;
Dvorakova, Hana;
Rosenberg, Ivan, SYNTHESIS OF N-(2-PHOSPHONYLMETHOXYETHYL) DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1989, 54(8), 2190 - 2210.
Holy, Antonin;
Dvorakova, Hana;
Rosenberg, Ivan, SYNTHESIS OF (3-HYDROXY-2-PHOSPHONYLMETHOXYPROPYL) DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1989, 54(9), 2470 - 2501.
Holy, Antonin, SYNTHESIS OF EIGHT STEREOISOMERIC 5-(ADENIN-9-YL)-2,3,4-TRIHYDROXYPENTANOIC ACIDS. Collect. Czech. Chem. Commun. 1982, 47(11), 2969 - 2988.
Holy, Antonin, PREPARATION OF ISOMERIC 3-AMINOPROPYLAMINO DERIVATIVES OF 9-(RS)-(2,3-DIHYDROXYPROPYL)ADENINE. Collect. Czech. Chem. Commun. 1983, 48(7), 1910 - 1921.
Holy, Antonin;
Masojidkova, Milena;
Rosenberg, Ivan, PHOSPHONYLMETHOXYALKYL AND PHOSPHONYLALKYL DERIVATIVES OF ADENINE. Collect. Czech. Chem. Commun. 1988, 53(11B), 2753 - 2777.
Holy, Antonin, BRANCHED-CHAIN DERIVATIVES OF ACYCLIC ADENOSINE ANALOGS: ALKYL AND HYDROXYMETHYL DERIVATIVES OF S-ADENOSYL-L-HOMOCYSTEINASE INHIBITORS SUBSTITUTED AT THE 2- AND 3-POSITION OF THE SIDE CHAIN. Collect. Czech. Chem. Commun. 1989, 54(1), 248 - 265.
Holy, Antonin;
Pristasova, Svetlana;
Rosenbergova, Marta, DECYCLIZING PHOSPHODIESTERASES ASSOCIATED WITH PLASMA MEMBRANES OF THE CHICK CHORIOALANTOIS. Collect. Czech. Chem. Commun. 1981, 46(2), 520 - 524.
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena, FLUORESCENT ANALOGUES OF ACYCLIC INHIBITORS OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. Collect. Czech. Chem. Commun. 1988, 53(8), 1779 - 1794.
Holy, Antonin;
Rosenberg, Ivan, PREPARATION OF 2'(3')-O-PHOSPHONYLMETHYL DERIVATIVES OF RIBONUCLEOSIDES. Collect. Czech. Chem. Commun. 1983, 48(3), 778 - 789.
Holy, Antonin, SYNTHESIS OF 3-AMINO- AND 3-AZIDOANALOGS OF 9-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROPYL)ADENINE (HPMPA). Collect. Czech. Chem. Commun. 1989, 54(2), 446 - 454.
Holy, Antonin;
Rosenberg, Ivan;
Horska, Kveta;
Cvekl, Ales;
Sebesta, Karel, TRINUCLEOTIDE AUA AND UAU FORMATION CATALYZED BY WHEAT GERM RNA POLYMERASE II. Collect. Czech. Chem. Commun. 1989, 54(3), 811 - 818.
Holy, Antonin;
Rosenberg, Ivan, PHOSPHONYLMETHYL ANALOGUES OF RIBONUCLEOSIDE 2',3'-CYCLIC PHOSPHATES AND 2'(3')-NUCLEOTIDE METHYL ESTERS: SYNTHESIS AND PROPERTIES. Collect. Czech. Chem. Commun. 1985, 50(7), 1507 - 1513.
Holy, Antonin;
Rosenberg, Ivan, AN IMPROVED SYNTHESIS OF S-ADENOSYL-L-HOMOCYSTEINE AND RELATED COMPOUNDS. Collect. Czech. Chem. Commun. 1985, 50(7), 1514 - 1518.
Budesinsky, Milos;
Holy, Antonin;
Masojidkova, Milena;
Rosenberg, Ivan;
Zajicek, Jaroslav, CONFORMATIONAL STUDY ON RIBONUCLEOSIDE O-PHOSPHONYLMETHYL DERIVATIVES BY 1H NMR SPECTROSCOPY. Collect. Czech. Chem. Commun. 1985, 50(8), 1899 - 1905.
Holy, Antonin;
et al.;
Votruba, Ivan;
Ewing, David F.;
Humble, Robert W.;
Mackenzie, Grahame, Synthesis of 4- and 5-amino-1-(2-deoxy-D-erythro-pentofuranosyl)imidazole nucleosides by chemical and biotransformation methods. Carbohydr. Res. 1991, 216(1), 109 - 118, 10.1016/0008-6215(92)84154-K .
.
Holy, Antonin, STEREOSPECIFIC SYNTHESIS OF ISOMERIC 4-SUBSTITUTED 9-(2,3-DIHYDROXYBUTYL)ADENINES. Collect. Czech. Chem. Commun. 1982, 47(1), 173 - 189.
Holy, Antonin;
Masojidkova, Milena;
Spassova, Maria K., RIBONUCLEOSIDES OF 3-AMINO- AND 3,5-DIAMINOPYRAZOLE-4-CARBOXYLIC ACID AND THEIR OPEN-CHAIR ANALOGUES: SYNTHESIS AND REACTIONS. Collect. Czech. Chem. Commun. 1986, 51(7), 1512 - 1531.
Holy, Antonin;
Votruba, Ivan;
Cihlar, Tomas;
Rosenberg, Ivan;
Horska, Kvetoslava;
Liboska, Radek, METABOLISM OF 1-(S)-(3-HYDROXY-2-PHOSPHONOMETHOXYPROPYL)CYTOSINE (HPMPC) IN HUMAN EMBRYONIC LUNG CELLS. Collect. Czech. Chem. Commun. 1992, 57(3), 661 - 672, 10.1135/cccc19920661 .
.
Holy, Antonin;
Jindrich, Jindrich;
Dvorakova, Hana, SYNTHESIS OF ISOMERIC N-(3-FLUORO-2-HYDROXYPROPYL) AND N-(2-FLUORO-3-HYDROXYPROPYL) DERIVATIVES OF PURINE AND PYRIMIDINE BASES. Collect. Czech. Chem. Commun. 1992, 57(7), 1466 - 1482, 10.1135/cccc19921466 .
.
Holy, Antonin;
Hrebabecky, Hubert, SYNTHESIS OF 1-(3-AZIDO-2,3-DIDEOXY-4-C-HYDROXYMETHYL-α-L-threo-PENTOFURANOSYL)THYMINE, 1-(2,3-DIDEOXY-4-C-HYDROXYMETHYL-α-L-glycero-PENTOFURANOSYL)THYMINE AND 1-(2,3-DIDEOXY-4-C-HYDROXYMETHYL-α-L-glycero-PENT-2-ENOFURANOSYL)THYMINE. Collect. Czech. Chem. Commun. 1993, 58(2), 409 - 420, 10.1135/cccc19930409 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, PREPARATION OF PURINE 2'-DEOXY-5'-O-PHOSPHONOMETHYLNUCLEOSIDES AND 2'-DEOXY-3'-O-PHOSPHONOMETHYLNUCLEOSIDES. Collect. Czech. Chem. Commun. 1993, 58(2), 421 - 434, 10.1135/cccc19930421 .
.
Holy, Antonin;
Dvorakova, Hana;
Votruba, Ivan;
Masojidkova, Milena, SYNTHESIS AND BIOLOGICAL EFFECTS OF ACYCLIC ANALOGS OF DEAZAPURINE NUCLEOSIDES. Collect. Czech. Chem. Commun. 1993, 58(3), 629 - 648, 10.1135/cccc19930629 .
.
Holy, Antonin, SYNTHESES OF ENANTIOMERIC N-(3-HYDROXY-2-PHOSPHONOMETHOXYPROPYL)DERIVATIVES OF PURINE AND PYRIMIDINE BASES. Collect. Czech. Chem. Commun. 1993, 58(3), 649 - 674, 10.1135/cccc19930649 .
.
Holy, Antonin;
Chen, Dong;
Bastian, Matthias;
Gregan, Fridrich;
Sigel, Helmut, Ternary Complexes in Solution (Part 55) with Phosphonates as Ligands. Various Intramolecular Equilibria in Mixed-ligand Complexes containing the Antiviral 9-(2-Phosphonomethoxyethyl)adenine, an Adenosine Monophosphate Analogue. J. Chem. Soc., Dalton Trans. (1972-1999) 1993(10), 1537 - 1546.
Holy, Antonin;
Alexander, Petr, GENERAL METHOD OF PREPARATION OF N-<(S)-(3-HYDROXY-2-PHOSPHONOMETHOXYPROPYL)> DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1993, 58, 1151 - 1163, 10.1135/cccc19931151 .
.
Holy, Antonin;
Dvorakova, Hana;
Alexander, Petr, SYNTHESIS AND BIOLOGICAL EFFECTS OF 9-(3-HYDROXY-2-PHOSPHONOMETHOXYPROPYL) DERIVATIVES OF DEAZAPURINE BASES. Collect. Czech. Chem. Commun. 1993, 58, 1403 - 1418, 10.1135/cccc19931403 .
.
Holy, Antonin;
Dvorakova, Hana, SYNTHESIS AND BIOLOGICAL EFFECTS OF N-(2-PHOSPHONO-METHOXYETHYL) DERIVATIVES OF DEAZAPURINE BASES. Collect. Czech. Chem. Commun. 1993, 58, 1419 - 1429, 10.1135/cccc19931419 .
.
Holy, Antonin;
Jindrich, Jindrich;
Dvorakova, Hana, SYNTHESIS OF N-(3-FLUORO-2-PHOSPHONOMETHOXYPROPYL) (FPMP) DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1993, 58(7), 1645 - 1667, 10.1135/cccc19931645 .
.
Holy, Antonin;
Hrebabecky, Hubert, SYNTHESIS OF 1-(2,3-DIDEOXY-4-C-METHYL-β-D-glycero-PENT-2-ENOFURANOSYL)THYMINE, 1-(2,3-DIDEOXY-4-C-METHYL-β-D-glycero-PENTOFURANOSYL)THYMINE AND 1-(4-C-AZIDOMETHYL-2-DEOXY-β-D-threoPENTOFURANOSYL)THYMINE. Collect. Czech. Chem. Commun. 1993, 58(7), 1668 - 1674, 10.1135/cccc19931668 .
.
Holy, Antonin;
Masojidkova, Milena;
Otmar, Miroslav;
Rosenberg, Ivan, <5-(ADENIN-9-YL)-5-DEOXYPENTOFURANOSYL>PHOSPHONATES - A NOVEL TYPE NUCLEOTIDE ANALOGS RELATED TO HPMPA. I. DERIVATIVES WITH L-arabino, D-arabino, 2-DEOXY-L-erythro AND 2-DEOXY-L-threo CONFIGURATION. Collect. Czech. Chem. Commun. 1993, 58(9), 2159 - 2179, 10.1135/cccc19932159 .
.
Holy, Antonin;
Masojidkova, Milena;
Otmar, Miroslav;
Rosenberg, Ivan, <5-(ADENIN-9-YL)-5-DEOXY-L-PENTOFURANOSYL>PHOSPHONATES - A NOVEL TYPE OF NUCLEOTIDE ANALOGS RELATED TO HPMPA. II. SYNTHESIS OF L-ribo and L-xylo CONFIGURATED DERIVATIVES BY RECYCLIZATION OF DIETHYL (5-RS)-<1,2-O-ISOPROPYLIDENE-5-O-METHANESULFONYL-D-PENTOFURANOS-5-C-YL>PHOSPHONATES .... Collect. Czech. Chem. Commun. 1993, 58(9), 2180 - 2196, 10.1135/cccc19932180 .
.
Holy, Antonin;
Hrebabecky, Hubert, SYNTHESIS OF 1-(3-AZIDO-2,3-DIDEOXY-β-D-ribo-HEXOFURANOSYL)-, 1-(2,3-DIDEOXY-β-D-erythro-HEXOFURANOSYL)- AND 1-(2,3-DIDEOXY-β-D-erythro-HEX-2-ENOFURANOSYL)PYRIMIDINE NUCLEOSIDES. Collect. Czech. Chem. Commun. 1994, 59(2), 412 - 420, 10.1135/cccc19940412 .
.
Budesinsky, Milos;
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Spassova, Maria, SYNTHEIS OF N-(3-AZIDO-2-HYDROXYPROPYL), N-(3-PHTHALIMIDO-2-HYDROXYPROPYL) AND N-(3-AMINO-2-HYDROXYPROPYL)DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1994, 59(5), 1153 - 1174, 10.1135/cccc19941153 .
.
Holy, Antonin;
Masojidkova, Milena;
Alexander, Petr, PREPARATION OF 9-(2-PHOSPHONOMETHOXYETHYL)ADENINE ESTERS AS POTENTIAL PRODRUGS. Collect. Czech. Chem. Commun. 1994, 59(8), 1853 - 1869, 10.1135/cccc19941853 .
.
Holy, Antonin;
Masojidkova, Milena;
Alexander, Petr, SYNTHESIS OF 9-(2-PHOSPHONOMETHOXYETHYL)ADENINE AND RELATED COMPOUNDS. Collect. Czech. Chem. Commun. 1994, 59(8), 1870 - 1878, 10.1135/cccc19941870 .
.
Holy, Antonin;
Sigel, Helmut;
Song, Bin, METAL ION-COORDINATING PROPERTIES OF THE ANTIVIRAL (S)-9-<3-HYDROXY-2-(PHOSPHONOMETHOXY)PROPYL>ADENINE (HPMPA) IN AQUEOUS SOLUTION. Gazz. Chim. Ital. 1994, 124(10), 387 - 392.
Holy, Antonin;
Hrebabecky, Hubert;
Dockal, Jan, SYNTHESIS OF DEOXY, DIDEOXY AND DIDEHYDRODIDEOXY ANALOGS OF 9-(β-D-HEXOFURANOSYL)ADENINE. Collect. Czech. Chem. Commun. 1994, 59(6), 1408 - 1419, 10.1135/cccc19941408 .
.
Holy, Antonin;
Hrebabecky, Hubert, SYNTHESIS OF DEOXY, DIDEOXY AND DIDEHHYDRODIDEOXY ANALOGS OF 9-(4-C-HYDROXYMETHYL-α-L-PENTOFURANOSYL)ADENINE. Collect. Czech. Chem. Commun. 1994, 59(7), 1654 - 1664, 10.1135/cccc19941654 .
.
Holy, Antonin;
Rosenberg, Ivan;
Cvorakova, Hana, SYNTHESIS OF SOME 2'-C-ALKYL DERIVATIVES OF 9-(2-PHOSPHONOMETHOXYETHYL)ADENINE AND RELATED COMPOUNDS. Collect. Czech. Chem. Commun. 1994, 59(9), 2069 - 2094, 10.1135/cccc19942069 .
.
Holy, Antonin;
Alexander, Petr, PRODRUGS OF ANALOGS OF NUCLEIC ACID COMPONENTS. Collect. Czech. Chem. Commun. 1994, 59(10), 2127 - 2165, 10.1135/cccc19942127 .
.
Holy, Antonin;
et al.;
Dvorakova, Hana;
Votruba, Ivan;
Hockova, Dana;
Guenter, Jaroslav, SYNTHESIS OF 2-DEOXY-β-D-RIBONUCLEOSIDES AND2,3-DIDEOXY.β-D-PENTOFURANOSIDES ON IMMOBILIZED BACTERIAL CELLS. Collect. Czech. Chem. Commun. 1994, 59(10), 2303 - 2330, 10.1135/cccc19942303 .
.
Budesinsky, Milos;
Holy, Antonin;
Masojidkova, Milena;
Hockova, Dana, ACYCLIC NUCLEOSIDE AND NUCLEOTIDE ANALOGS DERIVED FROM 2-AZAADENINE. Collect. Czech. Chem. Commun. 1995, 60(2), 224 - 236, 10.1135/cccc19950224 .
.
Holy, Antonin;
Jurikova, Kristina;
Smrckova, Svatava, SYNTHESIS OF BASE-MODIFIED "ABBREVIATED" NAD ANALOGUES. Collect. Czech. Chem. Commun. 1995, 60(2), 237 - 250, 10.1135/cccc19950237 .
.
Krecmerova, Marcela;
Holy, Antonin, PREPARATION OF PHOSPHONOMETHYL ETHERS DERIVED FROM 2-PHENYLETHANOL AND ITS AMINO DERIVATIVES. Collect. Czech. Chem. Commun. 1995, 60(4), 659 - 669, 10.1135/cccc19950659 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena, SYNTHESIS OF 3-(4-PYRIDINYL)-, 3-(2-CHLORO-4-PYRIDINYL)- AND 3-(2-AMINO-4-PYRIDINYL)PROPOXYMETHANEPHOSPHONIC ACID. Collect. Czech. Chem. Commun. 1995, 60(4), 670 - 680, 10.1135/cccc19950670 .
.
Holy, Antonin;
Votruba, Ivan;
Birkus, Gabriel;
Kramata, Pavel;
Cerny, Jaroslav;
Otova, Berta, DNA-POLYMERASES α, δ AND ε FROM T-CELL SPONTANEOUS LYMPHOBLASTIC LEUKEMIA OF SPRAGUE-DAWLEY INBRED RAT: ISOLATION AND CHARACTERIZATION. Collect. Czech. Chem. Commun. 1995, 60(9), 1555 - 1572, 10.1135/cccc19951555 .
.
Holy, Antonin;
Masojidkova, Milena, SYNTHESIS OF ENANTIOMERIC N-(2-PHOSPHONOMETHOXYPROPYL) DERIVATIVES OF PURINE AND PYRIMIDINE BASES. I. THE STEPWISE APPROACH. Collect. Czech. Chem. Commun. 1995, 60(7), 1196 - 1212, 10.1135/cccc19951196 .
.
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena, SYNTHESIS OF ENANTIOMERIC N-(2-PHOSPHONOMETHOXYPROPYL)DERIVATIVES OF PURINE AND PYRIMIDINE BASES. II. THE SYNTHON APPROACH. Collect. Czech. Chem. Commun. 1995, 60(8), 1390 - 1409, 10.1135/cccc19951390 .
.
Holy, Antonin;
Hockova, Dana;
Votavova, Hana, Synthesis and Chiroptical Properties of Some Abbreviated NAD Analogues. Tetrahedron Asymmetry 1995, 6(9), 2375 - 2384, 10.1016/0957-4166(95)00315-G .
.
Holy, Antonin;
Masojidkova, Milena;
Votavova, Hana;
Janeba, Zlatko, Intramolecular cyclization of some acyclic nucleoside analogs. Collect. Czech. Chem. Commun. 1996, 61(3), 442 - 457, 10.1135/cccc19960442 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of 5-phenyl-2(1H)-pyrimidinone nucleosides. Collect. Czech. Chem. Commun. 1996, 61(3), 458 - 477, 10.1135/cccc19960458 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, 2′,3′-dideoxy- and 3′-azido-2′,3′-dideoxynucleosides of 5-phenyl-2(1H)-pyrimidinone. Preparation of 2′,3′-dideoxypentofuranoses. Collect. Czech. Chem. Commun. 1996, 61(3), 478 - 488, 10.1135/cccc19960478 .
.
Krecmerova, Marcela;
Holy, Antonin;
Hrebabecky, Hubert, Preparation of 5-benzyluracil and 5-benzylcytosine nucleosides as potential inhibitors of uridine phosphorylase. Collect. Czech. Chem. Commun. 1996, 61(4), 627 - 644, 10.1135/cccc19960627 .
.
Krecmerova, Marcela;
Holy, Antonin;
Hrebabecky, Hubert, Synthesis of 5-phenylcytosine nucleoside derivatives. Collect. Czech. Chem. Commun. 1996, 61(4), 645 - 655, 10.1135/cccc19960645 .
.
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik, Synthesis of 2'-aminomethyl derivatives of N-(2- (phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents. Journal of Medicinal Chemistry 1996, 39(17), 3263 - 3268, 10.1021/jm9601314 .
.
Budesinsky, Milos;
Holy, Antonin;
Jindrich, Jindrich;
Dvorakova, Hana;
Masojidkova, Milena;
Balzarini, Jan;
De Clercq, Erik;
Andrei, Graciella, Acyclic nucleotide analogs derived from 8-azapurines: Synthesis and antiviral activity. Journal of Medicinal Chemistry 1996, 39(20), 4073 - 4088, 10.1021/jm960314q .
.
Holy, Antonin;
Masojidkova, Milena;
Hockova, Dana, "Abbreviated" NADanalogues containing a phosphonate function. Collect. Czech. Chem. Commun. 1996, 61(10), 1538 - 1548, 10.1135/cccc19961538 .
.
Holy, Antonin;
Masojidkova, Milena;
Otmar, Miroslav, Two Synthetic Approaches to 9-Deaza Analogues of 9-(2,3-Dihydroxypropyl)adenine (DHPA). Collect. Czech. Chem. Commun. 1996, 61, S49 - S51.
Holy, Antonin;
Hockova, Dana, "Abbreviated" NAD Analogues Containing a Phosphonate Function. Collect. Czech. Chem. Commun. 1996, 61, S52 - S54.
Holy, Antonin;
Janeba, Zlatko, Intramolecular Cyclization of Some (S)-9-(3-Hydroxy-2-phosphonomethoxypropyl)adenine Derivatives. Collect. Czech. Chem. Commun. 1996, 61, S116 - S117.
Holy, Antonin;
Hrebabecky, Hubert;
Chu, Lan Dinh, A New Synthesis of 2,2'-Anhydro-5-alkyl/alryl-3-glycosyluracils. Collect. Czech. Chem. Commun. 1996, 61, S129 - S131.
Holy, Antonin;
Votruba, Ivan;
Zidek, Zdenek, Inhibition of Murine Lymphocyte Proliferation by N-Substituted Acyclic Purine Nucleoside Phosphonates. Collect. Czech. Chem. Commun. 1996, 61, S182 - S187.
Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Birkus, Gabriel;
Kramata, Pavel, Structural Features of Acyclic Nucleotide Analogs Conferring Inhibitory Effects on Cellular Replicative DNA Polymerases. Collect. Czech. Chem. Commun. 1996, 61, S188 - S191.
Holy, Antonin;
Dvorakova, Hana;
Sigel, Helmut;
Blindauer, Claudia A.;
Emwas, Abdul H.;
Sletten, Einar, Complex formation of the antiviral 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) and of its N1, N3, and N7 deaza derivatives with copper(II) in aqueous solution. Chemistry - A European Journal 1997, 3(9), 1526 - 1536.
Holy, Antonin;
Rosenberg, Ivan;
Zajicek, Jaroslav;
Liboska, Radek;
Tocik, Zdenek;
Fazakerley, G. Victor;
Guschlbauer, Wilhelm, Conformational studies on diribonucleoside monophosphate analogs containing a nonisosteric, isopolar, phosphonate-based internucleotide linkage. Collect. Czech. Chem. Commun. 1997, 62(1), 83 - 98.
Holy, Antonin;
Balzarini, Jan;
Hrebabecky, Hubert, Preparation of chloro and sulfanyl derivatives of 1-(2-deoxy-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)uracil. Collect. Czech. Chem. Commun. 1997, 62(7), 1114 - 1127.
Holy, Antonin;
Hrebabecky, Hubert, Preparation of thymidine-4′-C-carboxylic acid and its derivatives. Collect. Czech. Chem. Commun. 1997, 62(7), 1128 - 1135.
Holy, Antonin;
Votruba, Ivan;
Cihlar, Tomas;
Olsanska, Lenka, Transport of adefovir (PMEA) in human T-lymphoblastoid cells. Collect. Czech. Chem. Commun. 1997, 62(5), 821 - 828.
Holy, Antonin;
Hockova, Dana, Synthesis of some "abbreviated" NAD analogues. Collect. Czech. Chem. Commun. 1997, 62(6), 948 - 956.
Budesinsky, Milos;
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert;
Havlas, Zdenek, 1-(3,5-O-alkylidene-2-deoxy-4-C-hydroxymethyl-α-L-threo- pentofuranosyl)uracils. Collect. Czech. Chem. Commun. 1997, 62(6), 957 - 970.
Holy, Antonin;
Dvorakova, Hana;
Sigel, Helmut;
Blindauer, Claudia A., Solution properties of antiviral adenine-nucleotide analogues. The acid - Base properties of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) and of its N1, N3 and N7 deaza derivatives in aqueous solution. Journal of the Chemical Society. Perkin Transactions 2 1997(11), 2353 - 2363.
Holy, Antonin, Simple method for cleavage of phosphonic acid diesters to monoesters. Synthesis 1998(4), 381 - 385.
Budesinsky, Milos;
Holy, Antonin;
Otmar, Miroslav;
Masojldkova, Milena, Catalytic hydrogenation causes C-benzyl bond cleavage in 6-amino-7,7-dibenzyl-2,4-dimethoxy-7H-pyrrolo[3,2-d]pyrimidine: An example indicating novel route to 6-amino-7-benzyl-5H-pyrrolo-[3,2-d]pyrimidines and related compounds. Tetrahedron 1998, 54(12), 2931 - 2940, 10.1016/S0040-4020(98)83028-7 .
.
Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Birkus, Gabriel;
Kramata, Pavel;
Otova, Berta, Nonproteolyzed form of DNA-polymerase ε from T-cell spontaneous lymphoma of Sprague-Dawley inbred rat: Isolation and characterization. Collect. Czech. Chem. Commun. 1998, 63(5), 723 - 731.
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of carba analogues of deoxy-4-C-(hydroxymethyl)-pentofuranoses, intermediates in the synthesis of carbocyclic nucleosides. Collect. Czech. Chem. Commun. 1998, 63(12), 2044 - 2064.
Podlaha, Jaroslav;
Cisarova, Ivana;
Budesinsky, Milos;
Holy, Antonin, Synthesis of quaternary 1-[2-(phosphonomethoxy)ethyl] derivatives of 2,4-diaminopyrimidine and related acyclic nucleotide analogs. Collect. Czech. Chem. Commun. 1999, 64(2), 242 - 256.
Holy, Antonin;
Votruba, Ivan;
Kramata, Pavel;
Otova, Berta, Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases α, δ, and ε. Molecular Pharmacology 1996, 49(6), 1005 - 1011.
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Guenter, Jaroslav, Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. Journal of Medicinal Chemistry 1999, 42(12), 2064 - 2086, 10.1021/jm9811256 .
.
Holy, Antonin;
Sigel, Helmut;
Blindauer, Claudia A., Metal ion-binding properties of the nucleotide analogue 1-[2-(phosphonomethoxy)ethyl]cytosine (PMEC) in aqueous solution. Collect. Czech. Chem. Commun. 1999, 64(4), 613 - 632.
Budesinsky, Milos;
Holy, Antonin;
Hockova, Dana;
Marek, Radek;
Marek, Jaromir, Regioselective preparation of N- and N-alkyl derivatives of N- [(dimethylamino)methylene]adenine bearing an active methylene group and their further derivatization leading to α-branched acyclic nucleoside analogues. European Journal of Organic Chemistry 1999(10), 2675 - 2682.
Holy, Antonin;
Sigel, Helmut;
Blindauer, Claudia A.;
Sletten, Einar;
Sjastad, Trond I., Aspects of the co-ordination chemistry of the antiviral nucleotide analogue, 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP). J. Chem. Soc., Dalton Trans. (1972-1999) 1999(21), 3661 - 3671.
Holy, Antonin;
Otova, Berta;
Zidek, Zdenek;
Frankova, Daniela, Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs. Eur. J. Pharmacol. 1995, 286(3), 307 - 310, 10.1016/0014-2999(95)00586-3 .
.
Holy, Antonin;
Saman, David;
Kolehmainen, Erkki;
Guenter, Jaroslav;
Lappalainen, Kari, C and N NMR chemical shift assignments of N-1-(2-azidoethyl)-4-R-pyrimidin-2-ones by H,X HMQ(B)C with z-gradient selection. Magn. Reson. Chem. 1998, 36(6), 442 - 444.
Holy, Antonin;
Votruba, Ivan;
Horska, Kvetoslava;
Krejcova, Romana, Isoenzymes of GMP kinase from L1210 cells: Isolation and characterization. Collect. Czech. Chem. Commun. 1999, 64(3), 559 - 570.
Holy, Antonin;
Hrebabecky, Hubert, Synthesis of carba analogues of 2′-deoxy-4′-C-(hydroxymethyl)nucleosides. Collect. Czech. Chem. Commun. 1999, 64(9), 1485 - 1496.
Krecmerova, Marcela;
Holy, Antonin;
Votruba, Ivan;
Hrebabecky, Hubert, Inhibitory potency of 5-benzyluracil, 5-phenylcytosine and 5- phenylpyrimidin-2-one nucleosides against uridine phosphorylase from mouse leukemic L1210 cells. Nucleosides and Nucleotides 1999, 18(11-12), 2551 - 2564.
Holy, Antonin;
Sigel, Helmut;
Gomez-Coca, Raquel B.;
Kapinos, Larisa E.;
Vilaplana, Rosario A.;
Gonzalez-Vilchez, Francisco, Metal ion-binding properties of 9-(4-phosphonobutyl)adenine (dPMEA), a sister compound of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), and quantification of the equilibria involving four Cu(PMEA) isomers. Journal of the Chemical Society, Dalton Transactions 2000(13), 2077 - 2084, 10.1039/b001588l .
.
Holy, Antonin;
Hrebabecky, Hubert, Synthesis of carbocyclic 4′-C-hydroxymethyl analogues of azidodeoxythymidine, deoxythymidine, deoxydidehydrothymidine and thymidine carba analogue with fused oxetane ring. Collect. Czech. Chem. Commun. 2000, 65(3), 395 - 406.
Holy, Antonin;
Masojidkova, Milena;
Meszarosova, Katerina, Synthesis of acyclic adenine 8,N-anhydronucleosides. Collect. Czech. Chem. Commun. 2000, 65(7), 1109 - 1125.
Holy, Antonin;
Masojidkova, Milena;
Janeba, Zlatko, Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purin-8(9H)-one. Collect. Czech. Chem. Commun. 2000, 65(7), 1126 - 1144.
Holy, Antonin;
Masojidkova, Milena;
Janeba, Zlatko, Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purine-8(9H)-thione and 8-(methylsulfanyl)adenine. Collect. Czech. Chem. Commun. 2000, 65(11), 1698 - 1712.
Budesinsky, Milos;
Holy, Antonin;
Masojidkova, Milena;
Alexander, Petr, Synthesis of acyclic nucleotide analogues derived from N-substituted isoguanine. Collect. Czech. Chem. Commun. 2000, 65(11), 1713 - 1725.
Holy, Antonin;
Votruba, Ivan;
Horska, Kvetoslava;
Krejcova, Romana, Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells. Collect. Czech. Chem. Commun. 2000, 65(10), 1653 - 1668.
Holy, Antonin;
Hrebabecky, Hubert, Synthesis of carba analogues of deoxy-4-C-(hydroxymethyl)-hexopyranoses, intermediates in the synthesis of carbocyclic nucleosides. Collect. Czech. Chem. Commun. 2001, 66(5), 785 - 798, 10.1135/cccc20010785 .
.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Otmar, Miroslav, An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives. Collect. Czech. Chem. Commun. 2001, 66(3), 500 - 506, 10.1135/cccc20010500 .
.
Holy, Antonin;
Masojidkova, Milena;
Otmar, Miroslav;
Polakova, Lucie, A facile synthesis of azetidin-2-ylphosphonic acid and its 1-alkyl derivatives. Collect. Czech. Chem. Commun. 2001, 66(3), 507 - 516, 10.1135/cccc20010507 .
.
Holy, Antonin;
Masojidkova, Milena;
Janeba, Zlatko, Synthesis of 8-amino-and N-substituted 8-aminoadenine derivatives of acyclic nucleoside and nucleotide analogs. Collect. Czech. Chem. Commun. 2001, 66(3), 517 - 532, 10.1135/cccc20010517 .
.
Holy, Antonin;
Sigel, Helmut;
Kampf, Gunnar;
Lueth, Marc Sven;
Mueller, Jens;
Lippert, Bernhard, Properties of the ternary (Dien)Pt(PMEA-N7) complex containing diethylenetriamine (Dien) and the antiviral 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Synthesis, biological screening, acid-base behaviour, and metal ion-binding in aqueous solution. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences 2000, 55(12), 1141 - 1152.
Holy, Antonin;
Sigel, Helmut;
Kapinos, Larisa E.;
Kampf, Gunnar;
Lueth, Marc Sven;
Mueller, Jens;
Lippert, Bernhard, Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA): Comparison of the acid-base and metal-ion-binding properties of PMEA, (Dien)Pt(PMEA-N1), and (Dien)Pt(PMEA-N7). Chemistry - A European Journal 2001, 7(9), 1899 - 1908, 10.1002/1521-3765(20010504)7:9 .
.
Holy, Antonin;
Masojidkova, Milena;
Janeba, Zlatko, Transformation of 8-[(2-hydroxyalkyl)sulfanyl]adenines to 6-amino-7H-purin-8(9H)-one derivatives. Collect. Czech. Chem. Commun. 2001, 66(9), 1393 - 1406, 10.1135/cccc20011393 .
.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Tloustova, Eva, Synthesis and cytostatic activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N-substituted adenines, 2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 2001, 66(10), 1545 - 1592.
Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Birkus, Gabriel, Interactions of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)-propyl]cytosine (cidofovir) diphosphate with DNA polymerases α, δ and ε*. Collect. Czech. Chem. Commun. 2001, 66(11), 1698 - 1706.
Holy, Antonin;
Cesnek, Michal;
Masojidkova, Milena, 6-Guanidinopurine nucleosides and their analogues. Tetrahedron 2002, 58(15), 2985 - 2996, 10.1016/S0040-4020(02)00186-2 .
.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve, 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. Journal of Medicinal Chemistry 2002, 45(9), 1918 - 1929, 10.1021/jm011095y .
.
Cisarova, Ivana;
Holy, Antonin;
Petricek, Vaclav;
Slouf, Miroslav, Charge density study of hydrogen [(2,4-diaminopyrimidin-1-io)methyl]phosphonate monohydrate. Acta Crystallographica Section B: Structural Science 2002, 58(3 PART 2), 519 - 529, 10.1107/S0108768102004020 .
.
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of racemic 2-hydroxy-4- and 2-hydroxy-5-(hydroxymethyl)cyclohexane nucleoside analogues. Collect. Czech. Chem. Commun. 2002, 67(11), 1681 - 1699, 10.1135/cccc20021681 .
.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Capek, Petr;
Otmar, Miroslav, A facile synthesis of 9-deaza analogue of olomoucine. Collect. Czech. Chem. Commun. 2003, 68(4), 779 - 791, 10.1135/cccc20030779 .
.
Budesinsky, Milos;
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena, Synthesis of optically active N-alkyl derivatives of (R)-3-(adenin-9-yl)-2-hydroxypropanoic acid and related compounds. Collect. Czech. Chem. Commun. 2003, 68(5), 931 - 950, 10.1135/cccc20030931 .
.
Holy, Antonin;
Sigel, Helmut;
Gomez-Coca, Raquel B.;
Vilaplana, Rosario A.;
Gonzalez-Vilchez, Francisco, Solution structures of binary and ternary metal ion complexes of 9-(5-phosphonopentyl)adenine (3′-deoxa-PEEA). A nucleotide analogue related to the antivirally active 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). European Journal of Inorganic Chemistry 2003(16), 2937 - 2947.
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana, 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy) ethoxy]pyrimidines-Acyclic Nucleoside Phosphonate Analogues with Antiviral Activity. Journal of Medicinal Chemistry 2003, 46(23), 5064 - 5073.
Holy, Antonin;
Cesnek, Michal;
Masojidkova, Milena, New 2-alkynyl derivatives of the acyclic nucleoside 9-(2,3-dihydroxypropyl) adenine and their 6-guanidinopurine counterparts as potential effectors of adenosine receptors. Collect. Czech. Chem. Commun. 2003, 68(11), 2201 - 2218, 10.1135/cccc20032201 .
.
Holy, Antonin;
Votruba, Ivan;
Birkus, Gabriel;
Kramata, Pavel;
Otova, Berta;
Hajek, Miroslav, Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases α, δ, and ε*. Antimicrobial Agents and Chemotherapy 2002, 46(5), 1610 - 1613, 10.1128/AAC.46.5.1610-1613.2002 .
.
Holy, Antonin;
Keith, Kathy A.;
Hitchcock, Michael J. M.;
Lee, William A.;
Kern, Earl R., Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication. Antimicrobial Agents and Chemotherapy 2003, 47(7), 2193 - 2198, 10.1128/AAC.47.7.2193-2198.2003 .
.
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert;
Sala, Michal, Synthesis of racemic 2-hydroxy-4- and 2-hydroxy-5-(hydroxymethyl) cyclohexane pyrimidine C-Nucleoside analogues. Collect. Czech. Chem. Commun. 2004, 69(4), 918 - 932, 10.1135/cccc20040918 .
.
Holy, Antonin;
Zidek, Zdenek;
Bortos, Sanaa;
William, Samia;
Hammam, Olfat, Activity of 9-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]Adenine against Schistosomiasis mansoni in Mice. Antimicrobial Agents and Chemotherapy 2003, 47(12), 3853 - 3858, 10.1128/AAC.47.12.3853-3858.2003 .
.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Hockova, Dana, An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6- iodopyrimidine and 2-amino-4,6-dichloropyrimidine. Tetrahedron 2004, 60(23), 4983 - 4987, 10.1016/j.tet.2004.04.035 .
.
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of purine nucleoside analogues derived from carbocyclic 5-C-(hydroxymethyl)hexopyranoses. Collect. Czech. Chem. Commun. 2004, 69(2), 435 - 452.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva, Involvement of adenosine A receptors in upregulation of nitric oxide by acyclic nucleotide analogues. Eur. J. Pharmacol. 2004, 501(1-3), 79 - 86, 10.1016/j.ejphar.2004.08.031 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena, Synthesis of N- and N-[2-hydroxy-3- (phosphonomethoxy)-propyl] derivatives of N-substituted adenines, 2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 2004, 69(10), 1889 - 1913, 10.1135/cccc20041889 .
.
Holy, Antonin;
Votruba, Ivan;
Tloust'Ova, Eva;
Otova, Berta;
Pomeisl, Karel, Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines. Biochemical Pharmacology 2005, 69(10), 1517 - 1521, 10.1016/j.bcp.2005.03.003 .
.
Holy, Antonin;
Masojidkova, Milena;
Zidek, Zdenek;
Kmonickova, Eva;
Dolakova, Petra, Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives. Bioorganic and Medicinal Chemistry 2005, 13(7), 2349 - 2354, 10.1016/j.bmc.2005.01.054 .
.
Holy, Antonin;
Masojidkova, Milena;
Hockova, Dana, Sonogashira cross-coupling in the synthesis of acyclic nucleoside phosphonates: Preparation of 6-[(phosphonomethoxy)alkynyl]- and 6-[(phosphonomethoxy)alkyl]pyrimidines. Collect. Czech. Chem. Commun. 2005, 70(2), 247 - 258, 10.1135/cccc20050247 .
.
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of racemic 9-(6- and 2,6-substituted 9H-purin-9-yl)-5- oxatricyclo[4.2.1.0]nonane-3-methanols, novel conformationally locked carbocyclic nucleosides. Collect. Czech. Chem. Commun. 2005, 70(1), 103 - 123, 10.1135/cccc20050103 .
.
Holy, Antonin;
Votruba, Ivan;
Tloust'Ova, Eva;
Hajek, Miroslav;
Matulova, Nadezda, Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates. Biochemical Pharmacology 2005, 70(6), 894 - 900, 10.1016/j.bcp.2005.06.007 .
.
Holy, Antonin;
Cesnek, Michal;
Masojidkova, Milena;
Zidek, Zdenek, Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6- guanidinopurines and their influence on the NO-production in macrophages. Bioorganic and Medicinal Chemistry 2005, 13(8), 2917 - 2926, 10.1016/j.bmc.2005.02.008 .
.
Holy, Antonin;
Masojidkova, Milena;
Dolakova, Petra, Synthesis of Base Substituted 2-Hydroxy-3-(purin-9-yl)-propanoic Acids and 4-(Purin-9-yl)-3-butenoic Acids. Nucleosides, Nucleotides and Nucleic Acids 2003, 22(12), 2145 - 2160, 10.1081/NCN-120026636 .
.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Potmesil, Petr, Purine P receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine. Eur. J. Pharmacol. 2006, 530(1-2), 179 - 187, 10.1016/j.ejphar.2005.11.037 .
.
Holy, Antonin;
Zidek, Zdenek;
Frankova, Daniela;
Boubelik, Michael;
Draber, Petr, Inhibition of murine macrophage nitric oxide synthase expression by a pivoxil prodrug of antiviral acyclic nucleotide analogue 9-(2-phosphonomethoxyethyl)adenine. Biochemical Pharmacology 1997, 54(8), 855 - 861, 10.1016/S0006-2952(97)00228-1 .
.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Tloust'Ova, Eva;
Hrebabecky, Hubert;
Horska, Kveta;
Nencka, Radim, Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorganic and Medicinal Chemistry Letters 2006, 16(5), 1335 - 1337, 10.1016/j.bmcl.2005.11.050 .
.
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of novel conformationally locked carbocyclic nucleosides derived from 5,5- and 6,6-bis(hydroxymethyl)bicyclo[2.2.1]heptan-2-ol. Collect. Czech. Chem. Commun. 2005, 70(4), 519 - 538, 10.1135/cccc20050519 .
.
Holy, Antonin;
Balzarini, Jan;
De Clercq, Erik;
Naesens;
Lenaerts;
Andrei;
Snoeck;
Van Beers, Antiadenovirus activities of several classes of nucleoside and nucleotide analogues. Antimicrobial Agents and Chemotherapy 2005, 49(3), 1010 - 1016, 10.1128/AAC.49.3.1010-1016.2005 .
.
Holy, Antonin;
Zidek, Zdenek;
Potmesil, Petr;
Kmoniekova, Eva, Immunobiological activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N-substituted adenines, and 2,6-diaminopurines. Eur. J. Pharmacol. 2003, 475(1-3), 149 - 159, 10.1016/S0014-2999(03)02110-1 .
.
Holy, Antonin;
Votruba, Ivan;
Schinkmanova, Marketa, N-Methyl-AMP aminohydrolase activates N-substituted purine acyclic nucleoside phosphonates. Biochemical Pharmacology 2006, 71(9), 1370 - 1376, 10.1016/j.bcp.2006.01.013 .
.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Otmar, Miroslav, Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9- deazapurine and related compounds. Bioorganic and Medicinal Chemistry 2004, 12(12), 3187 - 3195, 10.1016/j.bmc.2004.04.003 .
.
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana, Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2- (phosphonomethoxy)ethoxy]pyrimidine and related compounds. Bioorganic and Medicinal Chemistry 2004, 12(12), 3197 - 3202, 10.1016/j.bmc.2004.04.002 .
.
Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Simple transformation of thymine 1-[3-hydroxy-2-(phosphonomethoxy)propyl] derivatives to their 1-[3-fluoro-2-(phosphonomethoxy)propyl] counterparts. Collect. Czech. Chem. Commun. 2005, 70(9), 1465 - 1481, 10.1135/cccc2 .
.
Holy, Antonin;
Masojidkova, Milena;
Pohl, Radek;
Otmar, Miroslav;
Bambuch, Vitezslav, C-Functionalization of 9-deazapurines by cross-coupling reactions. Tetrahedron 2007, 63(7), 1589 - 1601, 10.1016/j.tet.2006.12.008 .
.
Holy, Antonin;
Votruba, Ivan;
Horska, Kvetoslava, Interaction of phosphates of the acyclic nucleoside phosphonates with nucleoside diphosphate kinase from yeast and bovine liver. Collect. Czech. Chem. Commun. 2006, 71(1), 35 - 43, 10.1135/cccc20060035 .
.
Holy, Antonin;
Pohl, Radek;
Horejsi, Katerina, Tricyclic purine analogs derived from 2-amino-6-chloropurine and 2,6-diaminopurine and their methylated quaternary salts. Collect. Czech. Chem. Commun. 2006, 71(1), 77 - 90, 10.1135/cccc20060077 .
.
Holy, Antonin;
Masojidkova, Milena;
Chalupova, Sarka, Synthesis of some N-substituted derivatives of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, cidofovir). Collect. Czech. Chem. Commun. 2005, 70(12), 2053 - 2065, 10.1135/cccc20052053 .
.
Holy, Antonin;
Masojidkova, Milena;
Chalupova, Sarka, Synthesis of N-substituted derivatives of 1-[2- (phosphonomethoxy)ethyl]cytosine and its diisopropyl ester as a model reaction for the synthesis of N-substituted derivatives of cidofovir. Collect. Czech. Chem. Commun. 2005, 70(12), 2066 - 2074, 10.1135/cccc20052066 .
.
Holy, Antonin;
Votruba, Ivan;
Krejcova, Romana;
Horska, Kvtoslava, Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes. Biochemical Pharmacology 2000, 60(12), 1907 - 1913, 10.1016/S0006-2952(00)00512-8 .
.
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Pohl, Radek;
Clercq, Erik de;
Horejsi, Katerina, Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity. Bioorganic and Medicinal Chemistry 2006, 14(23), 8057 - 8065, 10.1016/j.bmc.2006.07.036 .
.
Holy, Antonin;
Masojidkova, Milena;
Pohl, Radek;
Vrbovska, Silvie, Bifunctional acyclic nucleoside phosphonates. 1. Symmetrical 1,3-bis[(phosphonomethoxy)propan-2-yl] derivatives of purines and pyrimidines. Collect. Czech. Chem. Commun. 2006, 71(4), 543 - 566, 10.1135/cccc20060543 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena, Preparation of C-5 substituted cidofovir derivatives. Collect. Czech. Chem. Commun. 2006, 71(4), 579 - 594, 10.1135/cccc20060579 .
.
Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Syntheses of base and side-chain modified pyrimidine 1-[2- (phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Collect. Czech. Chem. Commun. 2006, 71(4), 595 - 624, 10.1135/cccc20060595 .
.
Holy, Antonin;
Votruba, Ivan;
Birkus, Gabriel;
Otova, Berta, 9-[2-(phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases α, δ, ε, and ε*. Biochemical Pharmacology 1999, 58(3), 487 - 492, 10.1016/S0006-2952(99)00118-5 .
.
Krecmerova, Marcela;
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Potmesil, Petr, Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N-substituted derivatives. Eur. J. Pharmacol. 2006, 540(1-3), 191 - 199, 10.1016/j.ejphar.2006.04.018 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve;
Piskala, Alois;
Neyts, Johan, Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2- (phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry 2007, 50(5), 1069 - 1077, 10.1021/jm061281+ .
.
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert;
Sala, Michal, Synthesis of novel racemic conformationally locked carbocyclic nucleosides derived from 7-substituted bicyclo[2.2.1]hept-5-ene-2,2-dimethanols. Collect. Czech. Chem. Commun. 2006, 71(5), 635 - 649, 10.1135/cccc20060635 .
.
Holy, Antonin;
Pohl, Radek;
Pomeisl, Karel, Pd-catalyzed Suzuki-Miyaura coupling reactions in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase. Tetrahedron Letters 2007, 48(17), 3065 - 3067, 10.1016/j.tetlet.2007.02.107 .
.
Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of novel conformationally locked carbocyclic nucleosides derived from 3-(hydroxymethyl)bicyclo[2.2.1]heptane-2,5-diol. Collect. Czech. Chem. Commun. 2006, 71(6), 871 - 888, 10.1135/cccc20060871 .
.
Holy, Antonin;
Masojidkova, Milena;
Dolakova, Petra, Efficient synthesis of pyrimidinecarbonitriles and their derivatives. Heterocycles 2007, 71(5), 1107 - 1115.
Holy, Antonin;
Sigel, Helmut;
Fernandez-Botello, Alfonso;
Escuer, Albert;
Solans, Xavier;
Font-Bardia, Merce;
Moreno, Virtudes, New ternary complexes of copper(II) with 2,2′-bipyridine (bpy) and phosphocholine (PCh) or the quaternary 1-(2-phosphonomethoxy)ethyl derivative of 2,4-diaminopyrimidine (PMEDAPy). European Journal of Inorganic Chemistry 2007(13), 1867 - 1873, 10.1002/ejic.200601002 .
.
Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Lebeau, Ilya, Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Antimicrobial Agents and Chemotherapy 2007, 51(6), 2268 - 2273, 10.1128/AAC.01422-06 .
.
Holy, Antonin;
Dracinsky, Martin;
Vrbkova, Silvie, Bifunctional acyclic nucleoside phosphonates: synthesis of chiral 9-{3-hydroxy[1,4-bis(phosphonomethoxy)]butan-2-yl} derivatives of purines. Tetrahedron Asymmetry 2007, 18(18), 2233 - 2247, 10.1016/j.tetasy.2007.09.021 .
.
Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Duraffour, Sophie;
Van Den Oord, Joost;
De Vos, Rita;
Crance, Jean-Marc;
Garin, Daniel, Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. Antimicrobial Agents and Chemotherapy 2007, 51(12), 4410 - 4419, 10.1128/AAC.00838-07 .
.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva, Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates. Eur. J. Pharmacol. 2007, 574(1), 77 - 84, 10.1016/j.ejphar.2007.07.024 .
.
Krecmerova, Marcela;
Holy, Antonin;
Renders, Marleen;
Emmerechts, Gert;
Rozenski, Jef;
Herdewijn, Piet, Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase. Angewandte Chemie - International Edition 2007, 46(14), 2501 - 2504, 10.1002/anie.200603435 .
.
Holy, Antonin;
Dracinsky, Martin;
Vrbkova, Silvie, Synthesis of phosphonomethoxyethyl or 1,3-bis(phosphonomethoxy)propan-2-yl lipophilic esters of acyclic nucleoside phosphonates. Tetrahedron 2007, 63(46), 11391 - 11398, 10.1016/j.tet.2007.08.081 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Pohl, Radek;
Naesens, Lieve;
Neyts, Johan, Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5- azacytosine: Synthesis and antiviral activity. Journal of Medicinal Chemistry 2007, 50(23), 5765 - 5772, 10.1021/jm0707166 .
.
Krecmerova, Marcela;
Holy, Antonin;
Votruba, Ivan;
Tloust'Ova, Eva;
Hajek, Miroslav, Alpha anomer of 5-aza-2′-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells. Biochemical Pharmacology 2008, 75(4), 965 - 972, 10.1016/j.bcp.2007.10.018 .
.
Holy, Antonin;
Cesnek, Michal;
Masojidkova, Milena;
Solinova, Veronika;
Koval, Dusan;
Kasicka, Vaclav, Synthesis and properties of 2-guanidinopurines. Collect. Czech. Chem. Commun. 2006, 71(9), 1303 - 1319, 10.1135/cccc20061303 .
.
Holy, Antonin;
Pechar, Michal;
Braunova, Alena;
Subr, Vladimir;
Ulbrich, Karel, Polymemc conjugates of 9-[2-(phosphonomethoxy)ethyl]purine with potential antiviral and cytostatic activity. Collect. Czech. Chem. Commun. 2006, 71(8), 1211 - 1220, 10.1135/cccc20061211 .
.
Holy, Antonin;
Cesnek, Michal;
Masojidkova, Milena;
Zidek, Zdenek;
Kmonickova, Eva, Synthesis of guanidino analogues of PMPDAP and their immunobiological activity. Bioorganic and Medicinal Chemistry 2008, 16(2), 965 - 980, 10.1016/j.bmc.2007.10.010 .
.
Holy, Antonin;
Antosiewicz, Jan;
Wielgus-Kutrowska, Beata;
Dlugosz, MacIej;
Bzowska, Agnieszka, Kinetics of binding of multisubstrate analogue inhibitor (2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine) with trimeric purine nucleoside phosphorylase. Nucleosides, Nucleotides and Nucleic Acids 2007, 26(8-9), 969 - 974, 10.1080/15257770701508323 .
.
Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Nucleosides, Nucleotides and Nucleic Acids 2007, 26(8-9), 1025 - 1028, 10.1080/15257770701508679 .
.
Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert, Synthesis of novel carbocyclic nucleosides and pro-tides derived from 4-oxatricyclo[4.2.1.0]nonane-9-methanol. Collect. Czech. Chem. Commun. 2007, 72(10), 1331 - 1349, 10.1135/cccc20071331 .
.
Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert;
Dejmek, Milan, Synthesis of novel carbocyclic nucleoside analogues derived from 2-(hydroxymethyl)bicyclo[2.2.1]heptane. Collect. Czech. Chem. Commun. 2007, 72(11), 1523 - 1544, 10.1135/cccc20071523 .
.
Holy, Antonin;
Jansa, Petr;
Votruba, Ivan;
Masojidkova, Milena;
Tloust'Ova, Eva;
Hrebabecky, Hubert;
Horska, Kveta;
Nencka, Radim, Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. Journal of Medicinal Chemistry 2007, 50(24), 6016 - 6023, 10.1021/jm070644i .
.
Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Syntheses of N-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase. Bioorganic and Medicinal Chemistry Letters 2008, 18(4), 1364 - 1367, 10.1016/j.bmcl.2008.01.006 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena, Pyrimidine acyclic nucleotide analogues with aromatic substituents in C-5 position. Collect. Czech. Chem. Commun. 2007, 72(7), 927 - 951, 10.1135/cccc20070927 .
.
Holy, Antonin;
Dracinsky, Martin;
Vrbkova, Silvie, Bifunctional acyclic nucleoside phosphonates: 2. Symmetrical 2-{[bis(phosphono)methoxy]methyl}ethyl derivatives of purines and pyrimidines. Collect. Czech. Chem. Commun. 2007, 72(7), 965 - 983, 10.1135/cccc20070965 .
.
Holy, Antonin;
Sigel, Helmut;
Gomez-Coca, Raquel B.;
Fernandez-Botello, Alfonso;
Moreno, Virtudes, Metal-ion binding properties of O-phosphonatomethylcholine (PMCh). Effect of the positive charge of a distant trimethylammonium group on the coordinating qualities of a phosph(on)ate group. Inorganica Chimica Acta 2002, 331(1), 109 - 116, 10.1016/S0020-1693(01)00763-0 .
.
Holy, Antonin;
Sigel, Helmut;
Fernandez-Botello, Alfonso;
Moreno, Virtudes;
Griesser, Rolf, Acid-base and metal-ion-binding properties of 9-[2-(2-phosphonoethoxy) ethyl]adenine (PEEA), a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). An exercise on the quantification of isomeric complex equilibria in solution. Inorganic Chemistry 2005, 44(14), 5104 - 5117, 10.1021/ic050341j .
.
Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin, Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy. Bioorganic and Medicinal Chemistry 2008, 16(14), 6778 - 6782, 10.1016/j.bmc.2008.05.058 .
.
Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert, Synthesis of novel carbocyclic nucleoside analogues containing bicyclo[2.2.1]hept-2-ene-2-methanol. Collect. Czech. Chem. Commun. 2008, 73(1), 44 - 58, 10.1135/cccc20080044 .
.
Holy, Antonin;
Votruba, Ivan;
Cihlar, Tomas;
Schinkmanova, Marketa;
Shibata, Riri;
Han, Bin;
Liu, Xiaohong, Human N-methyl-AMP/dAMP aminohydrolase (abacavir 5-monophosphate deaminase) is capable of metabolizing N-substituted purine acyclic nucleoside phosphonates. Collect. Czech. Chem. Commun. 2008, 73(2), 275 - 291, 10.1135/cccc20080275 .
.
Krecmerova, Marcela;
Holy, Antonin;
Votruba, Ivan;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Naesens, Lieve;
Neyts, Johan, Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. Biochemical Pharmacology 2008, 76(8), 997 - 1005, 10.1016/j.bcp.2008.08.009 .
.
Holy, Antonin;
Sigel, Helmut;
Fernandez-Botello, Alfonso;
Moreno, Virtudes;
Operschall, Bert P., Intramolecular π-π stacking interactions in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and the nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antivirally active 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Inorganica Chimica Acta 2009, 362(3), 799 - 810, 10.1016/j.ica.2008.02.035 .
.
Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert;
Neyts, Johan;
De Palma, Armando M., Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol. Collect. Czech. Chem. Commun. 2009, 74(3), 487 - 502, 10.1135/cccc2008204 .
.
Holy, Antonin;
Dracinsky, Martin;
Fanfrlik, Jindrich;
Dolakova, Petra, Synthesis of analogues of Acyclic nucleoside diphosphates containing a (phosphonomethyl)phosphanyl moiety and studies of their phosphorylation. European Journal of Organic Chemistry 2009(7), 1082 - 1092, 10.1002/ejoc.200800911 .
.
Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert;
Neyts, Johan;
De Palma, Armando M., Synthesis of novel racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.0]nonane- 9-methanol and 4-oxatricyclo[4.3.1.0]decane-10-methanol, compounds with activity against coxsackie viruses. Collect. Czech. Chem. Commun. 2009, 74(3), 469 - 485, 10.1135/cccc2008193 .
.
Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Dolakova, Petra;
Solinova, Veronika;
Kasicka, Vaclav, Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines. European Journal of Medicinal Chemistry 2009, 44(6), 2408 - 2424, 10.1016/j.ejmech.2008.09.031 .
.
Budesinsky, Milos;
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Kovackova, Sona, Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp-hybridised C-5 carbon atom. European Journal of Organic Chemistry 2009(24), 4117 - 4122, 10.1002/ejoc.200900529 .
.
Holy, Antonin;
Pohl, Radek;
Horska, Kvetoslava;
Pomeisl, Karel, Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase. Tetrahedron 2009, 65(41), 8486 - 8492, 10.1016/j.tet.2009.08.039 .
.
Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Hrebabecky, Hubert;
Sala, Michal;
Neyts, Johan;
De Palma, Armando M., Norbornane as the novel pseudoglycone moiety in nucleosides. Tetrahedron 2009, 65(45), 9291 - 9299, 10.1016/j.tet.2009.09.018 .
.
Holy, Antonin;
Hockova, Dana;
Keough, Dianne T.;
Naesens, Lieve M. J.;
Skinner-Adams, Tina S.;
De Jersey, John;
Guddat, Luke W., Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics. Journal of Medicinal Chemistry 2009, 52(14), 4391 - 4399, 10.1021/jm900267n .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena, Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position. Bioorganic and Medicinal Chemistry 2010, 18(1), 387 - 395, 10.1016/j.bmc.2009.10.044 .
.
Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert, New carbocyclic nucleoside analogues built on a bicyclo[2.2.2]octane-2,2- dimethanol template. Collect. Czech. Chem. Commun. 2009, 74(9), 1425 - 1441, 10.1135/cccc2009090 .
.
Holy, Antonin;
Masojidkova, Milena;
Janeba, Zlatko, Alternative synthesis of 9-{3-[(diisopropoxyphosphoryl)-methoxy]-2- hydroxypropyl}adenine and its free phosphonates substituted at the c-8 position of purine base. Collect. Czech. Chem. Commun. 2010, 75(3), 371 - 381, 10.1135/cccc2009569 .
.
Holy, Antonin;
Dracinsky, Martin;
Hockova, Dana, Synthesis and properties of a novel type of acyclic nucleoside phosphonates: 2-(purin-9-yl)ethoxyphenylphosphonic acids. European Journal of Organic Chemistry 2010(15), 2885 - 2892, 10.1002/ejoc.201000061 .
.
Holy, Antonin;
Masojidkova, Milena;
Sala, Michal;
Neyts, Johan;
De Palma, Armando M.;
Hebabecky, Hubert;
Draeinsky, Martin, Synthesis of novel racemic carbocyclic nucleosides derived from 5,6-disubstituted norbornene. Collect. Czech. Chem. Commun. 2010, 75(1), 1 - 20, 10.1135/cccc2009116 .
.
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Pohl, Radek;
Clercq, Erik de;
Janeba, Zlatko, Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base. Canadian Journal of Chemistry 2010, 88(7), 628 - 638, 10.1139/V10-054 .
.
Holy, Antonin;
Sigel, Helmut;
Fernandez-Botello, Alfonso;
Moreno, Virtudes;
Operschall, Bert P., Metal ion-binding properties of 9-[(2-phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antiviral nucleotide analogue 9-[(2- phosphonomethoxy)ethyl]adenine (PMEA). Steric guiding of metal ion-coordination by the purine-amino group. Dalton Transactions 2010, 39(27), 6344 - 6354, 10.1039/c005238h .
.
Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert;
Sala, Michal;
Nencka, Radim;
Neyts, Johan;
De Palma, Armando M.;
Leyssen, Pieter, Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors. Bioorganic and Medicinal Chemistry 2010, 18(12), 4374 - 4384, 10.1016/j.bmc.2010.04.081 .
.
Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Pohl, Radek;
Cihlar, Tomas;
Naesens, Lieve;
Pomeisl, Karel;
Neyts, Johan;
Tichy, Tomas;
Brehova, Petra;
Laflamme, Genevieve;
Hui, Hon, Synthesis of ester prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl] -2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. Journal of Medicinal Chemistry 2010, 53(19), 6825 - 6837, 10.1021/jm901828c .
.
Holy, Antonin;
Sala, Michal;
Nencka, Radim;
Dejmek, Milan;
Hebabecky, Hubert;
Drainsky, Martin, Two convergent approaches toward novel carbocyclic C-nucleosides. Synthesis 2010(23), 4119 - 4130, 10.1055/s-0030-1258271 .
.
Holy, Antonin;
Masojidkova, Milena;
Hockova, Dana;
Keough, Dianne T.;
Guddat, Luke W.;
Jersey, John de, Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorganic and Medicinal Chemistry 2009, 17(17), 6218 - 6232, 10.1016/j.bmc.2009.07.044 .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Janeba, Zlatko;
Sala, Michal;
Cechova, Lucie, The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines. Tetrahedron 2011, 67(5), 866 - 871, 10.1016/j.tet.2010.12.040 .
.
Holy, Antonin;
Votruba, Ivan;
Balzarini, Jan;
Herman, Brian D.;
Sluis-Cremer, Nicolas, The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization. Journal of Biological Chemistry 2010, 285(16), 12101 - 12108, 10.1074/jbc.M109.096529 .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Chocholouasova, Jana;
Vacek, Jaroslav;
Kovackova, Soaa, Mechanism of the isotopic exchange reaction of the 5-H hydrogen of uracil derivatives in water and nonprotic solvents. European Journal of Organic Chemistry 2011(4), 777 - 785, 10.1002/ejoc.201001335 .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Votruba, Ivan;
Balzarini, Jan;
Klepetarova, Blanka;
Clercq, Erik de;
Janeba, Zlatko;
Baszczynski, Ondrej, Synthesis and antiviral activity of N-[3-fluoro-2- (phosphonomethoxy)propyl] analogues derived from N-substituted adenines and 2,6-diaminopurines. Bioorganic and Medicinal Chemistry 2011, 19(7), 2114 - 2124, 10.1016/j.bmc.2011.02.050 .
.
Holy, Antonin;
Elbert, Tomas;
Brehova, Petra, The preparation of H-labeled acyclic nucleoside phosphonates and study of their stability. Collect. Czech. Chem. Commun. 2010, 75(7), 757 - 766, 10.1135/cccc2010020 .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Cesnek, Michal;
Janeba, Zlatko;
Baszczynski, Ondrej, Efficient and 'green' microwave-assisted synthesis of haloalkylphosphonates via the Michaelis-Arbuzov reaction. Green Chemistry 2011, 13(4), 882 - 888, 10.1039/c0gc00509f .
.
Holy, Antonin;
Pohl, Radek;
Janeba, Zlatko;
Brehova, Petra;
Sedlacek, Ondrej, The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy) ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions. Canadian Journal of Chemistry 2011, 89(4), 488 - 498, 10.1139/V11-001 .
.
Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Tichy, Tomas, New prodrugs of Adefovir and Cidofovir. Bioorganic and Medicinal Chemistry 2011, 19(11), 3527 - 3539, 10.1016/j.bmc.2011.04.016 .
.
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Hockova, Dana, Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity. Bioorganic and Medicinal Chemistry 2011, 19(15), 4445 - 4453, 10.1016/j.bmc.2011.06.045 .
.
Holy, Antonin;
Votruba, Ivan;
Fanfrlik, Jindrich;
Tloustova, Eva;
Horska, Kvetoslava;
Brehova, Petra;
Tryznova, Jana;
Prenosil, Ondrej, Inhibition of human purine nucleoside phosphorylase by tenofovir phosphate congeners. Collect. Czech. Chem. Commun. 2010, 75(12), 1249 - 1257, 10.1135/cccc2010094 .
.
Krecmerova, Marcela;
Holy, Antonin;
Cesnek, Michal;
Hockova, Dana;
Naesens, Lieve;
Keough, Dianne T.;
De Jersey, John;
Guddat, Luke W.;
Brereton, Ian M.;
Winzor, Donald J., Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy. Molecular and Biochemical Parasitology 2010, 173(2), 165 - 169, 10.1016/j.molbiopara.2010.05.018 .
.
Holy, Antonin;
Dracinsky, Martin;
Cesnek, Michal;
Janeba, Zlatko;
Brehova, Petra, The efficient synthesis of 2-arylpyrimidine acyclic nucleoside phosphonates using Liebeskind-Srogl cross-coupling reaction. Tetrahedron 2011, 67(38), 7379 - 7385, 10.1016/j.tet.2011.07.040 .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Votruba, Ivan;
Mackman, Richard;
Cihlar, Tomas;
Bahador, Gina;
Janeba, Zlatko;
Zidek, Zdenek;
Baszczynski, Ondrej;
Stepan, George, A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities. European Journal of Medicinal Chemistry 2011, 46(9), 3748 - 3754, 10.1016/j.ejmech.2011.05.040 .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Balzarini, Jan;
Klepetarova, Blanka;
Janeba, Zlatko;
Baszczynski, Ondrej;
Hradil, Ondrej, An efficient microwave-assisted synthesis and biological properties of polysubstituted pyrimidinyl- and 1,3,5-triazinylphosphonic acids. Tetrahedron 2012, 68(3), 865 - 871, 10.1016/j.tet.2011.11.040 .
.
Holy, Antonin;
Dracinsky, Martin;
Cesnek, Michal;
Hockova, Dana;
Keough, Dianne T.;
Guddat, Luke W.;
Jersey, John de;
Baszczynski, Ondrej, Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorganic and Medicinal Chemistry 2012, 20(2), 1076 - 1089, 10.1016/j.bmc.2011.11.034 .
.
Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Hockova, Dana;
Keough, Dianne T.;
Guddat, Luke W., Synthesis of purine N-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorganic and Medicinal Chemistry 2012, 20(3), 1222 - 1230, 10.1016/j.bmc.2011.12.034 .
.
Holy, Antonin;
Votruba, Ivan;
Tloustova, Eva;
Mertlikova-Kaiserova, Helena;
Rumlova, Michaela;
Prochazkova, Eliska, Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG. Biochemical Pharmacology 2011, 82(2), 131 - 138, 10.1016/j.bcp.2011.04.002 .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Mertlikova-Kaiserova, Helena;
Prochazkova, Eliska, Determination of the antioxidative activity of substituted 5-aminopyrimidines. Free Radical Research 2012, 46(1), 61 - 67, 10.3109/10715762.2011.638292 .
.
Krecmerova, Marcela;
Holy, Antonin;
Jansa, Petr;
Otmar, Miroslav;
Baszczynski, Ondrej;
Blazek, Jiri;
Kaiser, Martin Maxmilian;
Drancinsky, Martin;
Kralova, Blanka, An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli. Bioorganic and Medicinal Chemistry 2012, 20(9), 3111 - 3118, 10.1016/j.bmc.2012.02.062 .
.
Holy, Antonin;
Korvasova, Zina;
Drasar, Lukas;
Masek, Josef;
Knotigova, Pavlina Turanek;
Kulich, Pavel;
Matiasovic, Jan;
Kovarcik, Kamil;
Bartheldyova, Eliska;
Koudelka, Stepan;
Skrabalova, Michaela;
Miller, Andrew D.;
Ledvina, Miroslav;
Turanek, Jaroslav, Antiviral effect of HPMPC (Cidofovir®), entrapped in cationic liposomes: In vitro study on MDBK cell and BHV-1 virus. Journal of Controlled Release 2012, 160(2), 330 - 338, 10.1016/j.jconrel.2012.01.040 .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Cechova, Lucie;
Mertlikova-Kaiserova, Helena;
Prochazkova, Eliska;
Brezinova, Anna, Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening. Bioorganic and Medicinal Chemistry Letters 2012, 22(20), 6405 - 6409, 10.1016/j.bmcl.2012.08.065 .
.
Holy, Antonin;
Sigel, Helmut;
Blindauer, Claudia A.;
Gomez-Coca, Raquel B.;
Operschall, Bert P.;
Sigel, Astrid, Extent of intramolecular π-stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and several 2-aminopurine derivatives of the antivirally active nucleotide analog 9-[2-(phosphonomethoxy) ethyl]adenine (PMEA). Chemistry and Biodiversity 2012, 9(9), 2008 - 2034, 10.1002/cbdv.201200022 .
.
Holy, Antonin;
De Clercq, Erik;
Naesens, Lieve;
Neyts, Johan;
Stittelaar, Koert J.;
Van Amerongen, Geert;
Van Lavieren, Rob F.;
Niesters, Hubert G. M.;
Fries, Edwin;
Maas, Chantal;
Mulder, Paul G. H.;
Van Der Zeijst, Ben A. M.;
Osterhaus, Albert D. M. E., Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. Nature 2006, 439(7077), 745 - 748, 10.1038/nature04295 .
.
Holy, Antonin;
Cesnek, Michal;
Solinova, Veronika;
Koval, Dusan;
Kasicka, Vaclav, Determination of acid-base dissociation constants of amino- and guanidinopurine nucleotide analogs and related compounds by capillary zone electrophoresis. Electrophoresis 2006, 27(5-6), 1006 - 1019, 10.1002/elps.200500815 .
.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Potmesil, Petr;
Anzenbacher, Pavel;
Anzenbacherova, Eva;
Buchar, Evzen, In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes. Journal of Biomedical Science 2006, 13(3), 295 - 301, 10.1007/s11373-005-9067-1 .
.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva, Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 2005, 149(2), 315 - 319.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Canova, Nikolina Kutinova;
Farghali, Hassan, Modulator of intracellular Ca(2+), thapsigargin, interferes with in vitro secretion of cytokines and nitric oxide.. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 2005, 149(2), 321 - 324.
Holy, Antonin;
Sigel, Helmut;
Gomez-Coca, Raquel B.;
Kapinos, Larisa E.;
Vilaplana, Rosario A.;
Gonzalez-Vilchez, Francisco, Quantification of isomeric equilibria formed by metal ion complexes of 8-[2-(phosphonomethoxy)ethyl]-8-azaadenine (8,8aPMEA) and 9-[2- (phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA). Derivatives of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy) ethyl]adenine (PMEA). Journal of Biological Inorganic Chemistry 2004, 9(8), 961 - 972, 10.1007/s00775-004-0591-7 .
.
Holy, Antonin;
Cesnek, Michal;
Jacobson, Kenneth A.;
Ohno, Michihiro;
Duong, Heng T.;
Kim, Soo-Kyung;
Tchilibon, Susanna;
Gao, Zhan-Guo, A neoceptor approach to unraveling microscopic interactions between the human A adenosine receptor and its agonists. Chemistry and Biology 2005, 12(2), 237 - 247, 10.1016/j.chembiol.2004.12.010 .
.
Holy, Antonin;
Smee, Donald F.;
Wandersee, Miles K.;
Bailey, Kevin W.;
Hostetler, Karl Y.;
Sidwell, Robert W., Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice. Antiviral Chemistry and Chemotherapy 2005, 16(3), 203 - 211.
Holy, Antonin;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana;
Schols, Dominique;
Van Laethem, Kristel;
Masojidkova, Milina, Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines. Journal of Antimicrobial Chemotherapy 2007, 59(1), 80 - 86, 10.1093/jac/dkl454 .
.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Potmesil, Petr;
Krizkova, Jana, Acyclic nucleoside phosphonate antivirals activate gene expression of monocyte chemotactic protein 1 and 3. Journal of Biomedical Science 2007, 14(1), 59 - 66, 10.1007/s11373-006-9116-4 .
.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Farghali, Hassan;
Melkusova, Petra, Nitric oxide production in mouse and rat macrophages: A rapid and efficient assay for screening of drugs immunostimulatory effects in human cells. Nitric Oxide - Biology and Chemistry 2007, 17(3-4), 160 - 169, 10.1016/j.niox.2007.06.006 .
.
Holy, Antonin;
Vavrova, Katerina;
Lorencova, Katerina;
Klimentova, Jana;
Novotny, Jakub;
Hrabalek, Alexandr, Transdermal and dermal delivery of adefovir: Effects of pH and permeation enhancers. European Journal of Pharmaceutics and Biopharmaceutics 2008, 69(2), 597 - 604, 10.1016/j.ejpb.2007.12.005 .
.
Holy, Antonin;
Vavrova, Katerina;
Lorencova, Katerina;
Novotny, Jakub;
Hrabalek, Alexandr, Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: Influence of pH, ion-pairing and skin species. European Journal of Pharmaceutics and Biopharmaceutics 2008, 70(3), 901 - 907, 10.1016/j.ejpb.2008.07.002 .
.
Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase.. Bioorganic and Medicinal Chemistry Letters 2008, 18(4), 1364 - 1367.
Holy, Antonin, Synthesis of acyclic analogs of adenosine.. Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2005, Chapter 14, Unit 14.1.
Holy, Antonin, Synthesis of acyclic nucleoside phosphonates.. Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2005, Chapter 14, Unit 14.2.
Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Gammon, Don B.;
Fiten, Pierre;
Opdenakker, Ghislain;
Evans, David H., Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs. Journal of Virology 2008, 82(24), 12520 - 12534, 10.1128/JVI.01528-08 .
.
Krecmerova, Marcela;
Holy, Antonin;
Renders, Marleen;
Herdewijn, Piet;
Lievrouw, Roel, Enzymatic polymerization of phosphonate nucleosides.. Chembiochem : a European journal of chemical biology 2008, 9(17), 2883 - 2888, 10.1002/cbic.200800494 .
.
Holy, Antonin;
Votruba, Ivan;
Otova, Berta;
Hrdy, Jiri, In Vivo modulation of angiogenic gene expression by acycl nucleoside phosphonates PMEDAP and PMEG. Anticancer Research 2009, 29(4), 1295 - 1302.
Holy, Antonin;
Solinova, Veronika;
Kasicka, Vaclav;
Sazelova, Petra, Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using β-CD as chiral selector. Electrophoresis 2009, 30(12), 2245 - 2254, 10.1002/elps.200800790 .
.
Holy, Antonin;
Votruba, Ivan;
Hajek, Miroslav;
Mertlikova-Kaiserova, Helena;
Cvilink, Viktor, Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP. Eur. J. Pharmacol. 2010, 643(1), 6 - 12, 10.1016/j.ejphar.2010.06.006 .
.
Holy, Antonin;
Votruba, Ivan;
Hajek, Miroslav;
Mertlikova-Kaiserova, Helena;
Matousova, Marika, Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells. Anticancer Research 2010, 30(7), 2791 - 2798.
Holy, Antonin;
Sigel, Helmut;
Gomez-Coca, Raquel B.;
Vilaplana, Rosario A.;
Gonzalez-Vilchez, Francisco, Nickel(II), Copper(II) and Zinc(II) complexes of 9-[2-(Phosphonomethoxy) Ethyl]-8-Azaadenine (9,Sapmea), the 8-Aza derivative of the antiviral nucleotide analogue 9-[2-(Phosphonomethoxy)Ethyl] Adenine (Pmea). Quantification of four isomeric species in aqueous solution. Bioinorganic Chemistry and Applications 2004, 2(3-4), 331 - 352.
Holy, Antonin;
Votruba, Ivan;
Fulnecek, Jaroslav;
Matyasek, Roman;
Krizova, Katerina;
Kovarik, Ales, Inhibition of SAH-hydrolase activity during seed germination leads to deregulation of flowering genes and altered flower morphology in tobacco. Molecular Genetics and Genomics 2011, 285(3), 225 - 236, 10.1007/s00438-011-0601-8 .
.
Holy, Antonin;
Vavrova, Katerina;
Hrabalek, Alexandr;
Kovarikova, Petra;
Skolova, Barbora;
Libalova, Martina;
Roh, Jaroslav;
Cap, Robert, Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr-PMEDAP. Pharmaceutical Research 2011, 28(12), 3105 - 3115, 10.1007/s11095-011-0508-4 .
.
Holy, Antonin;
Votruba, Ivan;
Spak, Josef;
Pavingerova, Daniela;
Spakova, Vlastimila;
Petrzik, Karel, Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants. Antiviral Research 2011, 92(2), 378 - 381, 10.1016/j.antiviral.2011.08.014 .
.
Holy, Antonin;
Hockova, Dana;
Naesens, Lieve;
Keough, Dianne T.;
De Jersey, John;
Guddat, Luke W., 6-oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugs. Current Topics in Medicinal Chemistry 2011, 11(16), 2085 - 2102, 10.2174/156802611796575911 .
.
Holy, Antonin;
Votruba, Ivan;
Spak, Josef;
Pavingerova, Daniela;
Spakova, Vlastimila;
Petrzik, Karel, Antiviral activity of acyclic nucleoside phosphonates PMEA, (S)-HPMPC, PMEDAP and ribavirin against Cauliflower mosaic virus in Brassica pekinensis. Plant Cell, Tissue and Organ Culture 2012, 110(1), 63 - 68, 10.1007/s11240-012-0130-0 .
.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Farghali, Hassan;
Kostecka, Petra, Differential effects of acyclic nucleoside phosphonates on nitric oxide and cytokines in rat hepatocytes and macrophages. International Immunopharmacology 2012, 12(2), 342 - 349, 10.1016/j.intimp.2011.12.005 .
.
Holy, Antonin;
Votruba, Ivan;
Mertlikova-Kaiserova, Helena;
Nejedla, Michaela, Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates. Anticancer Research 2012, 32(2), 497 - 501.
Holy, Antonin;
Sigel, Helmut;
Blindauer, Claudia A.;
Operschall, Bert P.;
Sigel, Astrid, Extent of intramolecular π stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and 1-[2-(phosphonomethoxy) ethyl]cytosine (PMEC), a relative of antivirally active acyclic nucleotide analogues (Part 72). Zeitschrift fur Anorganische und Allgemeine Chemie 2013, 639(8-9), 1661 - 1673, 10.1002/zaac.201300095 .
.
Holy, Antonin;
Wielgus-Kutrowska, Beata;
Bzowska, Agnieszka;
Koellner, Gertraud;
Stroh, Albrecht;
Raszewski, Grzegorz;
Steiner, Thomas;
Frank, Joachim, Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: Important implications for the mechanism of catalysis. Journal of Molecular Biology 2004, 342(3), 1015 - 1032, 10.1016/j.jmb.2004.07.017 .
.
Holy, Antonin;
Sigel, Helmut;
Fernandez-Botello, Alfonso;
Moreno, Virtudes, Intramolecular stacking interactions in ternary copper(II) complexes formed by a heteroaromatic amine and 9-[2-(2-phosphonoethoxy)ethyl]adenine, a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine. Journal of Inorganic Biochemistry 2004, 98(12), 2114 - 2124, 10.1016/j.jinorgbio.2004.08.001 .
.
Holy, Antonin;
Votruba, Ivan;
Otova, Berta;
Valerianova, Marie;
Bila, Vlasta;
Hanzalova, Jitka;
Eckschlager, Tomas;
Krejci, Ondrej;
Trka, Jan, PMEDAP and its N-Substituted Derivatives: Genotoxic Effect and Apoptosis in in vitro Conditions. Anticancer Research 2003, 23(6 C), 4933 - 4939.
Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Birkus, Gabriel;
Rosenberg, Ivan;
Rejman, Dominik, The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases α, δ and ε. Antiviral Chemistry and Chemotherapy 2004, 15(1), 23 - 33.
Holy, Antonin;
Zidek, Zdenek;
Potmesil, Petr, Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes. Toxicology and Applied Pharmacology 2003, 192(3), 246 - 253, 10.1016/S0041-008X(03)00215-1 .
.
Holy, Antonin;
Sigel, Helmut;
Gomez-Coca, Raquel B.;
Kapinos, Larisa E.;
Vilaplana, Rosario A.;
Gonzalez-Vilchez, Francisco, Intramolecular stacking interactions in ternary copper(II) complexes formed with 2,2′-bipyridine or 1,10-phenanthroline and 9-(4-phosphonobutyl)adenine (dPMEA), the carba relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Journal of Inorganic Biochemistry 2001, 84(1-2), 39 - 46, 10.1016/S0162-0134(00)00194-X .
.
Holy, Antonin;
Sigel, Helmut;
Gomez-Coca, Raquel B.;
Kapinos, Larisa E.;
Vilaplana, Rosario A.;
Gonzalez-Vilchez, Francisco, Ternary copper(II) complexes in solution formed with 8-AZA derivatives of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Metal-Based Drugs 2000, 7(6), 313 - 324.
Holy, Antonin;
Votruba, Ivan;
Otova, Berta;
Francova, Klara;
Franek, Frantisek;
Koutnik, Pavel;
Sladka, Milada;
Schramlova, Jana, 9-[2-(Phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP) - a potential drug against hematological malignancies - induces apoptosis. Anticancer Research 1999, 19(4 B), 3173 - 3182.
Holy, Antonin;
Kovarik, Ales;
Van Houdt, Helena;
Depicker, Anna, Drug-induced hypomethylation of a posttranscriptionally silenced transgene locus of tobacco leads to partial release of silencing. FEBS Letters 2000, 467(1), 47 - 51, 10.1016/S0014-5793(00)01077-2 .
.
Holy, Antonin;
Votruba, Ivan;
Otova, Berta;
Bobkova, Klara;
Marinov, Iuri;
Mandys, Vaclav;
Panczak, Ales, Anticancer effect of PMEDAP - Monitoring of apoptosis. Anticancer Research 2000, 20(2 A), 1041 - 1047.
Holy, Antonin;
Zidek, Zdenek;
Frankova, Daniela, Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). Eur. J. Pharmacol. 1999, 376(1-2), 91 - 100, 10.1016/S0014-2999(99)00343-X .
.
Holy, Antonin;
Votruba, Ivan;
Eckschlager, Tomas;
Franek, Frantisek, Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines. International Journal of Oncology 1999, 14(4), 745 - 752.
Holy, Antonin;
Dvorakova, Hana;
Sigel, Helmut;
Blindauer, Claudia A., Facilitation of the copper(II)-promoted dephosphorylation of adenosine 5′-triphosphate (ATP) by the antiviral nucleotide analogue, 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Chemical Communications 1998(11), 1219 - 1220.
Holy, Antonin;
Votruba, Ivan;
Eckschlager, Tomas;
Franek, Frantisek, Modulation of cell cycle progression and of antibody production in mouse hybridomas by a nucleotide analogue. Cytotechnology 1998, 28(1-3), 65 - 72.
Holy, Antonin;
Jindrich, Jindrich;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve;
Hartmann, Katrin;
Kuffer, Manuela;
Goldberg, Michel;
Erfle, Volker;
Goebel, Frank-Detlef;
Bischofberger, Norbert;
Kraft, Wilfried, Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1998, 17(2), 120 - 128.
Holy, Antonin;
Votruba, Ivan;
Otova, Berta;
Zidek, Zdenek;
Sladka, Milada;
Marinov, Iuri;
Leskova, Veronika, Antitumor activity of novel purine acyclic nucleotide analogs pmea and pmedap. In Vivo 1997, 11(2), 163 - 168.
Holy, Antonin;
Kaminsky, Ronald;
Nickel, Beatrice, Arrest of Trypanosoma brucei rhodesiense and T. brucei brucei in the S-phase of the cell cycle by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine ((S)-HPMPA). Molecular and Biochemical Parasitology 1998, 93(1), 91 - 100, 10.1016/S0166-6851(98)00023-1 .
.
Holy, Antonin;
Votruba, Ivan;
Kovarik, Ales;
Fojtova, Miloslava, Evaluation of the impact of S-adenosylhomocysteine metabolic pools on cytosine methylation of the tobacco genome. European Journal of Biochemistry 1998, 252(3), 347 - 352.
Holy, Antonin;
Dvorakova, Hana;
Sigel, Helmut;
Blindauer, Claudia A., Magnesium complexes of the antiviral 9-[2- (phosphonomethoxy)ethyl]adenine (PMEA) and of its 1-, 3-, and 7-deaza analogues in aqueous solution. Journal of Biological Inorganic Chemistry 1, 3(4), 423 - 433, 10.1007/s007750050252 .
.
Holy, Antonin;
Votruba, Ivan;
Otova, Berta;
Zidek, Zdenek;
Sladka, Milada;
Marinov, Iuri;
Leskova, Veronika, Antitumor activity of novel purine acyclic nucleotide analogs PMEA and PMEDAP. In Vivo 1997, 11(2), 163 - 167.
Holy, Antonin;
Zidek, Zdenek;
Frankova, Daniela, Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl) adenine stimulates cytokine and nitric oxide production. Eur. J. Pharmacol. 1997, 331(2-3), 245 - 252, 10.1016/S0014-2999(97)01004-2 .
.
Holy, Antonin;
Masojidkova, Milena;
Otmar, Miroslav, Reductive cyclization of 6-cyanomethyl-5-nitropyrimidines - An efficient route to 7-alkyl-5H-pyrrolo[3,2-d]pyrimidines and 6-amino-7,7-dialkyl-7H-pyrrolo[3,2-d]pyrimidines. Utilization in the synthesis of 9-deaza analogues of DHPA. Tetrahedron 1997, 53(1), 391 - 400, 10.1016/S0040-4020(96)00993-3 .
.
Holy, Antonin;
De Clercq, Erik;
Naesens, Lieve;
Kaminsky, Ronald;
Schmid, Cecile;
Grether, Yvonne;
Brun, Reto, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA]: A purine analogue with trypanocidal activity in vitro and in vivo. Tropical Medicine and International Health 1996, 1(2), 255 - 263.
Holy, Antonin;
Smee, Donald F.;
Sidwell, Robert W.;
Barnett, Bill B.;
Reist, Elmer J., Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus. Antiviral Research 1995, 26(1), 1 - 9, 10.1016/0166-3542(94)00061-C .
.
Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Rosenberg, Ivan;
Merta, Ales;
Travnicek, Miloslav;
Rebabecky, Hubert H., Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues. Antiviral Research 1990, 13(6), 287 - 293, 10.1016/0166-3542(90)90013-W .
.
Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Rosenberg, Ivan;
Hrebabecky, Hubert;
Merta, Ales;
Bernaerts, Ria, Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues. Antiviral Research 1990, 13(5), 209 - 218, 10.1016/0166-3542(90)90066-G .
.
Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Rosenberg, Ivan;
Cerny, Jaroslav;
Vonka, Vladimir, Phosphonylmethyl ethers of acyclic nucleoside analogues: Inhibitors of HSV-1 induced ribonucleotide reductase. Antiviral Research 1990, 13(5), 253 - 263, 10.1016/0166-3542(90)90070-N .
.
Holy, Antonin;
Votruba, Ivan;
Rosenberg, Ivan;
Cerny, Jaroslav;
Vonka, Vladimir;
Anisimova, Emma, Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant. Antiviral Research 1990, 14(2), 117 - 121, 10.1016/0166-3542(90)90049-D .
.
Holy, Antonin;
Votruba, Ivan;
Hasobe, Masahide;
Borchardt, Ronald T., 2-methylpropyl ester of 3-(adenin-9-YL)-2-hydroxypropanoic acid: Mechanism of antiviral action in vaccinia virus-infected L929 cells. Biochemical Pharmacology 1990, 39(10), 1573 - 1580, 10.1016/0006-2952(90)90523-N .
.
Holy, Antonin;
Jindrich, Jindrich;
Votruba, Ivan;
Otmar, Miroslav;
Cihlar, Tomas;
Rosenberg, Ivan;
Merta, Ales;
Herve, Tchaou Y., Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP (dAMP) kinase from L1210 cells. Biochemical Pharmacology 1992, 44(10), 2067 - 2077, 10.1016/0006-2952(92)90110-5 .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Hockova, Dana;
Janeba, Zlatko;
Keough, Dianne T.;
Guddat, Luke W.;
Baszczynski, Ondrej, The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. European Journal of Medicinal Chemistry 2013, 67, 81 - 89, 10.1016/j.ejmech.2013.06.032 .
.
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Schols, Dominique;
Balestra, Emanuela;
Huskens, Dana;
Vanpouille, Christophe;
Introini, Andrea;
Zicari, Sonia;
Liekens, Sandra;
Perno, Carlo-Federico;
Margolis, Leonid, A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity. PLoS Pathogens 2013, 9(7), 10.1371/journal.ppat.1003456 .
.
Patents
Holy, Antonin;
Hrebanecky, Hubert, 1-(3,5-Di-0-benzoyl-2-deoxy-beta-D-threo-pentofuranosyl)thymine and the method of producing the same, EP301908, 1989.
Holy, Antonin;
Jindrich, Jindrich;
Balzarini, Jan;
De Clercq, Erik, Antiretroviral bases, EP454427, 1991.
Holy, Antonin;
Rosenberg, Ivan, 9-(Phosphonylmethoxyalkyl) adenines, method for their preparation and their use, EP206459, 1992.
Holy, Antonin;
Jindrich, Jindrich, DI(2-PROPYL)ESTERS OF 1-FLUORO-2-PHOSPHONOMETHOXY-3-P-TOLUENESULFONYLOXYPROPANES, THEIR PRODUCING AND UTILIZATION, WO1992/20692, 1992.
Holy, Antonin;
Votruba, Ivan;
Tloustova, Eva;
Hajek, Miroslav;
Matulova, Nadezda, USE OF COMPOUNDS TO ENHANCE PROCESSIVITY OF TELOMERASE, WO2006/114064, 2006.
Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Naesens, Lieve;
Piskala, Alois;
Neyts, Johan, AZACYTOSINE DERIVATIVES USEFUL AS ANTIVIRAL AGENTS, WO2007/65231, 2007.
Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Piskala, Alois;
Kovarik, Ales;
Fojtova, Miloslava;
BARTOVA, Eva, 1-(2-DEOXY-ALPHA-D-ERYTHRO-PENTOFURANOSYL)-5-AZACYTOSINE FOR USE AS DRUG, WO2008/83634, 2008.
Holy, Antonin;
Hrebabecky, Hubert;
Sala, Michal;
Neyts, Johan;
DE PALMA, Armando, NEW ANTIVIRAL COMPOUNDS, WO2008/131502, 2008.
Holy, Antonin;
Otmar, Miroslav;
Piskala, Alois, METHOD OF MANUFACTURING 1-(2-DEOXY-ALPHA-D-ERYTHRO-PENTOFURANOSYL)-5-AZACYTOSINE, WO2008/101448, 2008.
Holy, Antonin;
Hrebabecky, Hubert;
Sala, Michal;
Neyts, Johan;
DE PALMA, Armando, NEW ANTI-VIRAL NUCLEOSIDE ANALOGS, WO2008/131501, 2008.
Holy, Antonin;
Hockova, Dana;
BALZARINI, Jan, Marie, Rene;
DE CLERCQ, Erik, Desire, Alice, PYRIMIDINE COMPOUNDS HAVING PHOSPHONATE GROUPS AS ANTIVIRAL NUCLEOTIDE ANALOGS, WO2004/111064, 2004.