Machara, Ales
Articles
Dvorakova, Hana;
Svoboda, Jiri;
Kozmik, Vaclav;
Petrickova, Hana;
Machara, Ales;
Kurfuerst, Milan, A nonconcerted cycloaddition of fused 2-vinylthiophenes with dimethyl acetylenedicarboxylate. Tetrahedron Letters 2004, 45(10), 2189 - 2192, 10.1016/j.tetlet.2004.01.030 
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Svoboda, Jiri;
Pojarova, Michaela;
Machara, Ales, Synthesis and cycloaddition reaction of 3-vinylthieno[3,2-b][1] benzothiophene. Collect. Czech. Chem. Commun. 2007, 72(7), 952 - 964, 10.1135/cccc20070952 .
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Dvorakova, Hana;
Svoboda, Jiri;
Kozmik, Vaclav;
Pojarova, Michaela;
Machara, Ales, Preparation and rearrangement study of novel thiophenium-and selenophenium-ylides. Collect. Czech. Chem. Commun. 2009, 74(5), 785 - 798, 10.1135/cccc2009001 .
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Machara, Ales;
Werner, Lukas;
Hudlicky, Tomas, Short chemoenzymatic azide-free synthesis of oseltamivir (tamiflu): Approaching the potential for process efficiency. Advanced Synthesis and Catalysis 2010, 352(1), 195 - 200, 10.1002/adsc.200900844 .
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Machara, Ales;
Werner, Lukas;
Hudlicky, Tomas;
Adams, David R.;
Cox, D. Phillip, Synthesis of buprenorphine from oripavine via N-demethylation of oripavine quaternary salts. Journal of Organic Chemistry 2011, 76(11), 4628 - 4634, 10.1021/jo200567n .
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Machara, Ales;
Werner, Lukas;
Hudlicky, Tomas;
Adams, David R.;
Sullivan, Bradford;
Carrera, Ignacio;
Moser, Michael;
Andraos, John, Several generations of chemoenzymatic synthesis of oseltamivir (Tamiflu): Evolution of strategy, quest for a process-quality synthesis, and evaluation of efficiency metrics. Journal of Organic Chemistry 2011, 76(24), 10050 - 10067, 10.1021/jo2018872 .
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Machara, Ales;
Werner, Lukas;
Hudlicky, Tomas;
Cox, D. Phillip;
Endoma-Arias, Mary Ann, Improved synthesis of buprenorphine from thebaine and/or oripavine via palladium-catalyzed N-demethylation/acylation and/or concomitant O-demethylation. Advanced Synthesis and Catalysis 2012, 354(4), 613 - 626, 10.1002/adsc.201100807 .
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Svoboda, Jiri;
Machara, Ales, Thiophenium-ylides: Synthesis and reactivity. Chem. Pap. 2013, 67(1), 59 - 65,7, 10.2478/s11696-012-0222-7 .
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Machara, Ales;
Hudlicky, Tomas;
Cox, D. Phillip, Synthesis of nalbuphine from oripavine via N-demethylation of N-cyclobutylmethyl oripavine. Heterocycles 2011, 84(1), 615 - 623, 10.3987/COM-11-S(P)32 .
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Machara, Ales;
Werner, Lukas;
Hudlicky, Tomas;
Adams, David R.;
Cox, D. Phillip;
Endoma-Arias, Mary Ann;
Wernerova, Martina;
Duchek, Jan, Unexpected N-demethylation of oxymorphone and oxycodone N-oxides mediated by the burgess reagent: Direct synthesis of naltrexone, naloxone, and other antagonists from oxymorphone. Advanced Synthesis and Catalysis 2012, 354(14-15), 2706 - 2712, 10.1002/adsc.201200676 .
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Machara, Ales;
Hudlicky, Tomas;
Cox, D.Phillip, Direct synthesis of naltrexone by palladium-catalyzed N-demethylation/ acylation of oxymorphone: The benefit of C-H activation and the intramolecular acyl transfer from C-14 hydroxy. Advanced Synthesis and Catalysis 2012, 354(14-15), 2713 - 2718, 10.1002/adsc.201200677 .
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Patents
Machara, Ales;
Werner, Lukas;
Hudlicky, Tomas;
Adams, David R.;
CARROLL, Robert;
LEISCH, Hannes, PROCESSES FOR THE PREPARATION OF MORPHINANE AND MORPHINONE COMPOUNDS, WO2010/121369, 2010.
Machara, Ales;
Werner, Lukas;
Hudlicky, Tomas, PROCESS AND COMPOUNDS FOR THE MANUFACTURE OF OSELTAMIVIR AND ANALOGS THEREOF, AND NEW ANTIVIRAL AGENTS, WO2011/47466, 2011.