Pincus, Matthew R.
Articles
Michl, Josef;
Sarafraz-Yazdi, Ehsan;
Bowne, Wilbur B.;
Adler, Victor;
Sookraj, Kelley A.;
Wu, Vernon;
Shteyler, Vadim;
Patel, Hunaiz;
Oxbury, William;
Brandt-Rauf, Paul;
Zenilman, Michael E.;
Pincus, Matthew R., Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(5), 1918 - 1923, 10.1073/pnas.0909364107 
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Michl, Josef;
Adler, Victor;
Pincus, Matthew R.;
Qu, Yongxia;
Chu, Tearina;
Platica, Ovidu;
Pestka, Sidney;
Izotova, Lara;
Boutjdir, Mohamed, Two dual specificity kinases are preferentially induced by wild-type rather than by oncogenic RAS-P21 in Xenopus oocytes. Frontiers in Bioscience 2006, 11(SUPPL. 2), 2420 - 2427, 10.2741/1979 .
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Michl, Josef;
Brandt-Rauf, Paul;
Pincus, Matthew R.;
Scharf, Bruce;
Schmidt, Anna;
Huynh, Chan;
Hannan, Raquibul;
Von Gizycki, Hans;
Friedman, Fred K.;
Fine, Robert L., PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo. International Journal of Cancer 2006, 119(7), 1577 - 1585, 10.1002/ijc.22029 .
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Michl, Josef;
Adler, Victor;
Pincus, Matthew R.;
Friedman, Fred K.;
Bowne, Wilbur;
Kamran, Ikram;
Chin, Edwin;
Zenilman, Michael, Two peptides derived from ras-p21 induce either phenotypic reversion or tumor cell necrosis of ras-transformed human cancer cells. Cancer Chemotherapy and Pharmacology 2008, 62(3), 491 - 498, 10.1007/s00280-007-0630-5 .
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Michl, Josef;
Adler, Victor;
Sookraj, Kelley A.;
Pincus, Matthew R.;
Qu, Yongxia;
Pestka, Sidney;
Izotova, Lara;
Friedman, Fred K.;
Bowne, Wilbur;
Zenilman, Michael;
Ikram, Kamran, Site-specific phosphorylation of raf in cells containing oncogenic ras-p21 is likely mediated by jun-N-terminal kinase. Annals of Clinical and Laboratory Science 2008, 38(1), 47 - 56.
Michl, Josef;
Sarafraz-Yazdi, Ehsan;
Bowne, Wilbur B.;
Adler, Victor;
Sookraj, Kelley A.;
Shteyler, Vadim;
Zenilman, Michael E.;
Pincus, Matthew R.;
Ikram, Kamran;
Vishnevetsky, Michael;
Lou, Sunming;
Koenke, Jesco;
Harding, Michael;
Bluth, Martin H.;
Ng, Mou;
Brandt-Rauf, Paul W.;
Hannan, Raqibul;
Bradu, Stephan, The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells. Annals of Surgical Oncology 2008, 15(12), 3588 - 3600, 10.1245/s10434-008-0147-0 .
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Michl, Josef;
Sarafraz-Yazdi, Ehsan;
Bowne, Wilbur B.;
Adler, Victor;
Sookraj, Kelley A.;
Pincus, Matthew R., The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide. Cancer Chemotherapy and Pharmacology 2010, 66(2), 325 - 331, 10.1007/s00280-009-1166-7 .
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Michl, Josef;
Sarafraz-Yazdi, Ehsan;
Adler, Victor;
Pincus, Matthew R.;
Bowne, Wilbur;
Fenelus, Maly, Anti-cancer peptides from Ras-P21 and P53 proteins. Current Pharmaceutical Design 2011, 17(25), 2677 - 2698.
Michl, Josef;
Pincus, Matthew R.;
Fine, Robert L.;
Brandt-Rauf, Paul W.;
Rosal, Ramon;
Wang, Hsin, NMR Solution Structure of a Peptide from the mdm-2 Binding Domain of the p53 Protein that Is Selectively Cytotoxic to Cancer Cells. Biochemistry 2004, 43(7), 1854 - 1861, 10.1021/bi035718g .
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Michl, Josef;
Pincus, Matthew R.;
Friedman, Fred K.;
Fine, Robert L.;
Brandt-Rauf, Paul W.;
Do, Tamara N.;
Rosal, Ramon V.;
Drew, Lisa;
Raffo, Anthony J.;
Petrylak, Daniel P.;
Cassai, Nicholas;
Szmulewicz, Joseph;
Sidhu, Gurdip, Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding site. Oncogene 2003, 22(10), 1431 - 1444, 10.1038/sj.onc.1206258 .
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Michl, Josef;
Pincus, Matthew R.;
Friedman, Fred K.;
Kanovsky, Mecheal;
Botzolaki, Georgia;
Morin, Joseph;
Kovac, Cecilia;
Chung, Denise L.;
Chie, Lyndon, Peptides designed from molecular modeling studies of the ras-p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on normal pancreatic acinar cell growth. Cancer Chemotherapy and Pharmacology 2003, 52(3), 202 - 208, 10.1007/s00280-003-0639-3 .
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Michl, Josef;
Pincus, Matthew R.;
Brandt-Rauf, Paul W.;
Kanovsky, Mecheal;
Chung, Denise L.;
Chie, Lyndon;
Way, Denise;
Smith, Steven;
Sivendran, Sharmila, A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti-ras peptide. Cancer Chemotherapy and Pharmacology 2002, 49(6), 429 - 437, 10.1007/s00280-002-0432-8 .
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Michl, Josef;
Pincus, Matthew R.;
Friedman, Fred K.;
Brandt-Rauf, Paul W.;
Kanovsky, Mecheal;
Chie, Lyndon;
Smith, Steven;
Ranginwale, Masood;
Flom, Judy;
Chung, Denise;
Robinson, Richard C.;
Yamaizumi, Ziro, Differences in patterns of activation of MAP kinase induced by oncogenic ras-p21 and insulin in oocytes. Experimental Cell Research 2001, 269(1), 162 - 169, 10.1006/excr.2001.5311 .
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Michl, Josef;
Pincus, Matthew R.;
Friedman, Fred K.;
Fine, Robert L.;
Brandt-Rauf, Paul W.;
Rosal, Ramon;
Drew, Lisa;
Kanovsky, Mecheal;
Raffo, Anthony;
Do, Tamara;
Rubinstein, Pablo;
Visser, Jan;
Robinson, Richard, Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells. Proceedings of the National Academy of Sciences of the United States of America 2001, 98(22), 12438 - 12443, 10.1073/pnas.211280698 .
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Michl, Josef;
Pincus, Matthew R.;
Friedman, Fred K.;
Brandt-Rauf, Paul W.;
Morin, Joseph;
Kovac, Cecilia;
Chung, Denise L.;
Chie, Lyndon;
Flom, Judy;
Yamaizumi, Ziro;
Robinson, Richard;
Kovac;
Chie;
Morin;
Friedman;
Robinson;
Chung;
Kanovsky;
Kanovsky, Mechael;
Flom;
Brandt-Rauf;
Yamaizumi;
Michl;
Pincus, Plasmid expression of a peptide that selectively blocks oncogenic ras-p21-induced oocyte maturation. Cancer Chemotherapy and Pharmacology 2001, 48(1), 9 - 14, 10.1007/s002800100288 .
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Michl, Josef;
Pincus, Matthew R.;
Friedman, Fred K.;
Brandt-Rauf, Paul W.;
Chung, Denise L.;
Chie, Lyndon;
Yamaizumi;
Chen, James M.;
Amar, Shazia, Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the guanine-nucleotide exchange protein, SOS, identified from molecular dynamics calculations. Selective inhibition of oncogenic ras-p21. Journal of Protein Chemistry 1999, 18(8), 875 - 879.
Michl, Josef;
Pincus, Matthew R.;
Friedman, Fred K.;
Brandt-Rauf, Paul W.;
Chung, Denise L.;
Chie, Lyndon;
Yamaizumi;
Chen, James M.;
Amar, Shazia, Identification of the site of inhibition of oncogenic ras-p21-induced signal transduction by a peptide from a ras effector domain. Journal of Protein Chemistry 1999, 18(8), 881 - 884.
Michl, Josef;
Pincus, Matthew R.;
Friedman, Fred K.;
Chung, Denise L.;
Chie, Lyndon;
Yamaizumi;
Chen, James M.;
Amar, Shazia;
Brandt-Kauf, Paul W., Inhibition of OncogenicActivated Wild-Type ras-p21 Protein-Induced Oocyte Maturation by Peptides from the Guanine-Nucleotide Exchange Protein, SOS, Identified from Molecular Dynamics Calculations. Selective Inhibition of Oncogenic ras-p21. Protein Journal 1999, 18(8), 875 - 879.
Michl, Josef;
Pincus, Matthew R.;
Friedman, Fred K.;
Chung, Denise L.;
Chie, Lyndon;
Yamaizumi;
Chen, James M.;
Amar, Shazia;
Brandt-Kauf, Paul W., Identification of the Site of Inhibition of Oncogenic ras-p21 -Induced Signal Transduction by a Peptide from a ras Effector Domain. Protein Journal 1999, 18(8), 881 - 884.
Patents
Michl, Josef;
Adler, Victor;
Pincus, Matthew R., PEPTIDES DERIVED FROM RAS-P21 AND USES THEREFOR, US2010/144636, 2010.