Hocek, Michal
Articles
Dvorak, Dalimil;
Havelkova, Martina;
Hocek, Michal;
Cesnek, Michal, The Suzuki-Miyaura cross-coupling reactions of 6-halopurines with boronic acids leading to 6-aryl- and 6-alkenylpurines. Synlett 1999(7), 1145 - 1147.
Dvorak, Dalimil;
Havelkova, Martina;
Hocek, Michal, Covalent analogues of DNA base-pairs and triplets. Part 3: Synthesis of 1,4- and 1,3-bis(purin-6-yl)benzenes and 1-(1,3-dimethyluracil-5-yl)-3 or 4-(purin-9-yl)benzenes. Tetrahedron 2002, 58(37), 7431 - 7435, 10.1016/S0040-4020(02)00833-5 
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Hocek, Michal;
Boehm, Stanislav;
Nespurek, Stanislav;
Kuthan, Josef, PHOTOCOLOURATION OF 2,4,4,6-TETRAARYL-1,4-DIHYDROPYRIDINES: A SEMIEMPIRICAL QUANTUM CHEMICAL STUDY. Collect. Czech. Chem. Commun. 1994, 59(2), 262 - 272, 10.1135/cccc19940262 .
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Hocek, Michal;
Boehm, Stanislav;
Kuthan, Josef;
Nemecek, Jan;
Havlicek, Vladimir, PREPARATION AND SPECTROSCOPIC PROPERTIES OF SPIROCYCLIC 1-METHYL-2,4,4,6-TETRAARYL-1,4-DIHYDROPYRIDINES. Collect. Czech. Chem. Commun. 1994, 59(5), 1105 - 1114, 10.1135/cccc19941105 .
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Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena, SYNTHESIS OF ACYCLIC NUCLEOTIDE ANALOGUES DERIVED FROM 2-(AMINOMETHYL)ADENINE AND 2-(AMINOMETHYL)HYPOXANTHINE. Collect. Czech. Chem. Commun. 1995, 60(5), 875 - 882, 10.1135/cccc19950875 .
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Holy, Antonin;
Hocek, Michal, A FACILE SYNTHESIS OF 6-CYANOPURINE BASES. Collect. Czech. Chem. Commun. 1995, 60(8), 1386 - 1389, 10.1135/cccc19951386 .
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Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik, Synthesis and antiviral activity of acyclic nucleotide analogues derived from 6-(aminomethyl)purines and purine-6-carboxamidines. Collect. Czech. Chem. Commun. 1996, 61(10), 1525 - 1537, 10.1135/cccc19961525 .
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Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena, Synthesis of acyclic nucleotide analogues derived from N-substituted 6-(1-aminoethyl)purines via 6-acetylpurine derivatives. Tetrahedron 1997, 53(6), 2291 - 2302, 10.1016/S0040-4020(96)01130-1 .
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Holy, Antonin;
Hocek, Michal, Acyclic Nucleotide Analogues Derived from 6-(1-Aminoalkyl)purines. Collect. Czech. Chem. Commun. 1996, 61, S55 - S58.
Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena, Synthesis of acyclic nucleotide analogues derived from 6-hetarylpurines via cross-coupling reactions of 9-[2-(diethoxyphosphonylmethoxy)ethyl]-6-iodopurine with hetaryl organometallic reagents. Collect. Czech. Chem. Commun. 1997, 62(1), 136 - 146.
Holy, Antonin;
Hocek, Michal, Perfluoroalkylation of 6-iodopurines by trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(perfluoroalkyl)purine bases, nucleosides and acyclic nucleotide analogues. Collect. Czech. Chem. Commun. 1999, 64(2), 229 - 241.
Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan;
Hockova, Dana, Synthesis and cytostatic activity of nucleosides and acyclic nucleoside analogues derived from 6-(trifluoromethyl)purines. Tetrahedron 1999, 55(36), 11109 - 11118, 10.1016/S0040-4020(99)00615-8 .
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Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: Application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids. Journal of Medicinal Chemistry 2000, 43(9), 1817 - 1825, 10.1021/jm991167+ .
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Dvorakova, Hana;
Stary, Ivo;
Hocek, Michal;
Stara, Irena G., Cyclotrimerization of 6-ethynylpurines. Synthesis of 1,2,4- and 1,3,5-tris(purin-6-yl)benzenes as novel Hoogsteen-triplet analogues. Tetrahedron Letters 2001, 42(3), 519 - 521.
Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-β-D-erythro-pentofuranosyl)-, 9-(5-deoxy-β-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines. Collect. Czech. Chem. Commun. 2000, 65(11), 1683 - 1697.
Holy, Antonin;
Hocek, Michal;
Cesnek, Michal, Synthesis of acyclic nucleotide analogues derived from 2-amino-6-C-substituted purines via cross-coupling reactions of 2-amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-halopurines with diverse organometallic reagents. Collect. Czech. Chem. Commun. 2000, 65(8), 1357 - 1373.
Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl-and 6-benzylpurine ribonucleosides. Collect. Czech. Chem. Commun. 2001, 66(3), 483 - 499, 10.1135/cccc20010483 .
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Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal, Cytostatic 6-arylpurine nucleosides IV. Synthesis of 2-substituted 6-phenylpurine ribonucleosides. Collect. Czech. Chem. Commun. 2002, 67(3), 325 - 335, 10.1135/cccc20020325 .
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Hocek, Michal;
Votruba, Ivan, Covalent analogues of DNA base-pairs and triplets. Part 2: Synthesis and cytostatic activity of bis(purin-6-yl)acetylenes, -diacetylenes and related compounds. Bioorganic and Medicinal Chemistry Letters 2002, 12(7), 1055 - 1058, 10.1016/S0960-894X(02)00077-X .
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Dvorakova, Hana;
Stary, Ivo;
Hocek, Michal;
Stara, Irena G., Covalent analogues of DNA base-pairs and triplets IV. Synthesis of trisubstituted benzenes bearing purine and/or pyrimidine rings by cyclotrimerization of 6-ethynylpurines and/or 5-ethynyl-1,3-dimethyluracil. Collect. Czech. Chem. Commun. 2002, 67(8), 1223 - 1235, 10.1135/cccc20021223 .
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Cisarova, Ivana;
Dvorakova, Hana;
Hocek, Michal, Covalent analogues of DNA base-pairs and triplets V. Synthesis of purine-purine and purine-pyrimidine conjugates connected by diverse types of acyclic carbon linkages. Collect. Czech. Chem. Commun. 2002, 67(10), 1560 - 1578, 10.1135/cccc20021560 .
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Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Synthesis of carba-analogues of myoseverin by regioselective cross-coupling reactions of 2,6-dichloro-9-isopropylpurine. Tetrahedron 2003, 59(5), 607 - 611, 10.1016/S0040-4020(02)01586-7 .
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Cisarova, Ivana;
Kotora, Martin;
Hocek, Michal;
Turek, Pavel, [2+2+2]-Co-cyclotrimerization 6-alkynylpurines with diynes: A method for preparation of 6-arylpurines. Tetrahedron Letters 2003, 44(4), 785 - 788, 10.1016/S0040-4039(02)02643-6 .
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Hocek, Michal;
Hockova, Dana;
Stambasky, Jan, Cytostatic 6-arylpurine nucleosides V. synthesis of 8-substituted 6-phenylpurine ribonucleosides. Collect. Czech. Chem. Commun. 2003, 68(5), 837 - 848, 10.1135/cccc20030837 .
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Dvorakova, Hana;
Hocek, Michal, An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines. Journal of Organic Chemistry 2003, 68(14), 5773 - 5776, 10.1021/jo034351i .
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Dvorakova, Hana;
Hocek, Michal;
Hockova, Dana, Dichotomy in regioselective cross-coupling reactions of 6,8-dichloropurines with phenylboronic acid and methylmagnesium chloride: Synthesis of 6,8-di-substituted purines. Synthesis 2004(6), 889 - 894.
Hocek, Michal, Synthesis of protected (purin-6-yl)glycines via Pd-catalyzed α-arylation of ethyl N-(diphenylmethylidene) glycinate with 6-iodopurines. Heterocycles 2004, 63(7), 1673 - 1677.
Hocek, Michal;
Hockova, Dana;
Seckarova, Pavlina;
Marek, Radek;
Malinakova, Katerina;
Kolehmainen, Erkki;
Sklenar, Vladimir, Direct determination of tautomerism in purine derivatives by low-temperature NMR spectroscopy. Tetrahedron Letters 2004, 45(33), 6259 - 6263, 10.1016/j.tetlet.2004.06.088 .
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Cisarova, Ivana;
Ludvik, Jiri;
Hocek, Michal;
Stepnicka, Petr;
Votruba, Ivan;
Reha, David;
Hobza, Pavel, Ferrocene-Modified Purines as Potential Electrochemical Markers: Synthesis, Crystal Structures, Electrochemistry and Cytostatic Activity of (Ferrocenylethynyl)- and (Ferrocenylethyl)purines. Chemistry - A European Journal 2004, 10(8), 2058 - 2066, 10.1002/chem.200305621 .
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Hocek, Michal;
Capek, Petr;
Pohl, Radek, A facile and efficient synthesis of (purin-6-yl)alanines. Journal of Organic Chemistry 2004, 69(23), 7985 - 7988, 10.1021/jo048812r .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan, Covalent analogues of DNA base-pairs and triplets VII. synthesis and cytostatic activity of bis(purin-6-yl)acetylene and -diacetylene nucleosides. Collect. Czech. Chem. Commun. 2004, 69(10), 1955 - 1970, 10.1135/cccc20041955 .
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Hocek, Michal;
Pohl, Radek, Regioselectivity in cross-coupling reactions of 2,6,8-trichloro-9- (tetrahydropyran-2-yl)purine: Synthesis of 2,6,8-trisubstituted purine bases. Synthesis 2004(17), 2869 - 2876, 10.1055/s-2004-834881 .
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Cisarova, Ivana;
Tislerova, Iva;
Kotora, Martin;
Hocek, Michal;
Votruba, Ivan;
Turek, Pavel, Cocyclotrimerization of 6-alkynylpurines with α,ω-diynes as a novel approach to biologically active 6-arylpurines. Journal of Organic Chemistry 2004, 69(26), 9224 - 9233, 10.1021/jo0486342 .
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Cisarova, Ivana;
Hocek, Michal;
Pohl, Radek, Highly methylated purines and purinium salts as analogues of heteromines. European Journal of Organic Chemistry 2005(14), 3026 - 3030, 10.1002/ejoc.200500154 .
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Hocek, Michal;
Capek, Petr;
Pohl, Radek, Synthesis of enantiomerically pure (purin-6-yl)phenylalanines and their nucleosides, a novel type of purine-amino acid conjugates. Journal of Organic Chemistry 2005, 70(20), 8001 - 8008, 10.1021/jo051110x .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka, A new modular and practical methodology for the synthesis of 4- or 3-substituted phenyl C-nucleosides. European Journal of Organic Chemistry 2005(21), 4525 - 4528, 10.1002/ejoc.200500607 .
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Kotora, Martin;
Hocek, Michal;
Votruba, Ivan;
Turek, Pavel, Novel method for preparation of highly substituted 6-arylpurines by reactions of 6-alkynylpurines with zirconacyclopentadienes. Collect. Czech. Chem. Commun. 2005, 70(3), 339 - 349, 10.1135/cccc20050339 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Silhar, Peter, Facile and efficient synthesis of 6-(hydroxymethyl)purines. Organic Letters 2004, 6(19), 3225 - 3228, 10.1021/ol049059r .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Furman, Phillip A.;
Tharnish, Phillip M.;
Otto, Michael J., Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides. Journal of Medicinal Chemistry 2005, 48(18), 5869 - 5873, 10.1021/jm050335x .
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Novak, Petr;
Kotora, Martin;
Hocek, Michal;
Pohl, Radek, Synthesis of C-aryldeoxyribosides by [2 + 2 + 2]-cyclotrimerization catalyzed by Rh, Ni, Co, and Ru complexes. Organic Letters 2006, 8(10), 2051 - 2054, 10.1021/ol060454m .
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Hocek, Michal;
Capek, Petr, Efficient one-step synthesis of optically pure (adenin-8-yl)phenylalanine nucleosides. Synlett 2005(19), 3005 - 3007, 10.1055/s-2005-921896 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Silhar, Peter, The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides. Organic and Biomolecular Chemistry 2005, 3(16), 3001 - 3007, 10.1039/b508122j .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Urban, Milan, New modular and efficient approach to 6-substituted pyridin-2-yl C-nucleosides. Journal of Organic Chemistry 2006, 71(19), 7322 - 7328, 10.1021/jo061080d .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Silhar, Peter, Synthesis of 2-substituted 6-(hydroxymethyl)purine bases and nucleosides. Collect. Czech. Chem. Commun. 2005, 70(10), 1669 - 1695, 10.1135/cccc20051669 .
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Novak, Petr;
Kotora, Martin;
Hocek, Michal;
Turek, Pavel;
Pohl, Radek, Preparation of highly substituted 6-arylpurine ribonucleosides by Ni-catalyzed cyclotrimerization. Scope of the reaction. Journal of Organic Chemistry 2006, 71(23), 8978 - 8981, 10.1021/jo061485y .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Cerna, Igor, Direct C-H arylation of purines: Development of methodology and its use in regioselective synthesis of 2,6,8-trisubstituted purines. Organic Letters 2006, 8(23), 5389 - 5392, 10.1021/ol062324j .
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Hocek, Michal;
Silhar, Peter;
Shih, I-hung;
Mabery, Eric;
Mackman, Richard, Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: Synthesis and evaluation of 6-substituted purine l-ribonucleosides. Bioorganic and Medicinal Chemistry Letters 2006, 16(20), 5290 - 5293, 10.1016/j.bmcl.2006.07.092 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Kuchar, Martin, Synthesis of purines bearing functionalized C-substituents by the conjugate addition of nucleophiles to 6-vinylpurines and 6-ethynylpurines. European Journal of Organic Chemistry 2006(22), 5083 - 5098, 10.1002/ejoc.200600545 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Silhar, Peter, Synthesis and cytostatic activity of novel 6-(Difluoromethyl)purine bases and nucleosides. Synthesis 2006(11), 1848 - 1852, 10.1055/s-2006-942365 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Klepetarova, Blanka;
Silhar, Peter, Synthesis of 6-amino-, 6-methyl- and 6-aryl-2-(hydroxymethyl)purine bases and nucleosides. Collect. Czech. Chem. Commun. 2006, 71(6), 788 - 803, 10.1135/cccc20060788 .
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Hocek, Michal;
Reha, David;
Hobza, Pavel, Exceptional thermodynamic stability of DNA duplexes modified by nonpolar base analogues is due to increased stacking interactions and favorable solvation: Correlated Ab initio calculations and molecular dynamics simulations. Chemistry - A European Journal 2006, 12(13), 3587 - 3595, 10.1002/chem.200501126 .
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Hocek, Michal;
Votruba, Ivan;
Hobza, Pavel;
Pohl, Radek;
Klepetarova, Blanka;
Mabery, Eric;
Mackman, Richard;
Vrabel, Milan;
Havran, Ludek;
Fojta, Miroslav;
Rulisek, Lubomir;
Zendlova, Lucie;
Shih, I.-Hung, Purines bearing phenanthroline or bipyridine ligands and their RuII complexes in position 8 as model compounds for electrochemical DNA labeling - Synthesis, crystal structure, electrochemistry, quantum chemical calculations, cytostatic and antiviral activity. European Journal of Inorganic Chemistry 2007(12), 1752 - 1769, 10.1002/ejic.200700030 .
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Hocek, Michal;
Capek, Petr;
Pohl, Radek, Cross-coupling reactions of unprotected halopurine bases, nucleosides, nucleotides and nucleoside triphosphates with 4-boronophenylalanine in water. Synthesis of (purin-8-yl)- and (purin-6-yl)phenylalanines. Organic and Biomolecular Chemistry 2006, 4(11), 2278 - 2284, 10.1039/b604010a .
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Hocek, Michal;
Capek, Petr;
Pohl, Radek;
Vrabel, Milan;
Hasnik, Zbynek, Aqueous-phase Suzuki-Miyaura cross-coupling reactions of free halopurine bases. Synthesis 2006(20), 3515 - 3526, 10.1055/s-2006-950240 .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Joubert, Nicolas, Modular and practical synthesis of 6-substituted pyridin-3-yl C-nucleosides. Journal of Organic Chemistry 2007, 72(18), 6797 - 6805, 10.1021/jo0709504 .
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Hocek, Michal;
Capek, Petr;
Pohl, Radek;
Cahova, Hana;
Gloeckner, Christian;
Marx, Andreas, An efficient method for the construction of functionalized dna bearing amino acid groups through cross-coupling reactions of nucleoside triphosphates followed by primer extension or PCR. Chemistry - A European Journal 2007, 13(21), 6196 - 6203, 10.1002/chem.200700220 .
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Hocek, Michal;
Silhar, Peter;
Hasnik, Zbynek, Synthesis of (purin-6-yl)acetates and 6-(2-hydroxyethyl)purines via cross-couplings of 6-chloropurines with the Reformatsky reagent. Tetrahedron Letters 2007, 48(32), 5589 - 5592, 10.1016/j.tetlet.2007.06.053 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Klepetarova, Blanka;
Vrabel, Milan, Synthesis of 2′-deoxyadenosine nucleosides bearing bipyridine-type ligands and their Ru-complexes in position 8 through cross-coupling reactions. Organic and Biomolecular Chemistry 2007, 5(17), 2849 - 2857, 10.1039/b709245h .
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Hocek, Michal;
Pohl, Radek;
Cerna, Igor, The first direct C-H arylation of purine nucleosides. Chemical Communications 2007(45), 4729 - 4730, 10.1039/b714253f .
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Hocek, Michal;
Pohl, Radek;
Silhar, Peter, Cytostatic and antiviral 6-arylpurine ribonucleosides VIII. Synthesis and evaluation of 6-substituted purine 3′-deoxyribonucleosides. Collect. Czech. Chem. Commun. 2006, 71(10), 1484 - 1496, 10.1135/cccc20061484 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Shih, I-hung;
Mabery, Eric;
Mackman, Richard;
Kuchar, Martin, Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides. Bioorganic and Medicinal Chemistry 2008, 16(3), 1400 - 1424, 10.1016/j.bmc.2007.10.063 .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Barta, Jan;
Ernsting, Nikolaus P., Modular synthesis of 5-substituted thiophen-2-yl C-2′- deoxyribonucleosides. Journal of Organic Chemistry 2008, 73(10), 3798 - 3806, 10.1021/jo800177y .
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Novak, Petr;
Kotora, Martin;
Hocek, Michal;
Cihalova, Sylva;
Otmar, Miroslav, Co- and homocyclotrimerization reactions of protected 1-alkynyl-2-deoxyribofuranose. Synthesis of C-nucleosides, C-di- and C-trisaccharide analogues. Tetrahedron 2008, 64(22), 5200 - 5207, 10.1016/j.tet.2008.03.046 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Silhar, Peter;
Shih, I-hung;
Mabery, Eric;
Mackman, Richard, Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides. Bioorganic and Medicinal Chemistry 2008, 16(5), 2329 - 2366, 10.1016/j.bmc.2007.11.067 .
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Hocek, Michal;
Silhar, Peter;
Hasnik, Zbynek, Hydroxymethylations of aryl halides by Pd-catalyzed cross-couplings with (benzoyloxy)methylzinc iodide - Scope and limitations of the reaction. Synlett 2008(4), 543 - 546, 10.1055/s-2008-1032084 .
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Hocek, Michal;
Pohl, Radek;
Vrabel, Milan;
Havran, Ludek;
Fojta, Miroslav;
Brazdilova, Petra;
Pivonkova, Hana, Ferrocenylethynyl derivatives of nucleoside triphosphates: Synthesis, incorporation, electrochemistry, and bioanalytical applications. Chemistry - A European Journal 2007, 13(34), 9527 - 9533, 10.1002/chem.200701249 .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Kuchar, Martin, Synthesis of diverse 6-(1,2-disubstituted ethyl)purine bases and nucleosides via 6-(oxiran-2-yl)purines. Tetrahedron 2008, 64(45), 10355 - 10364, 10.1016/j.tet.2008.08.074 .
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Hocek, Michal;
Fojta, Miroslav, Cross-coupling reactions of nucleoside triphosphates followed by polymerase incorporation. Construction and applications of base-functionalized nucleic acids. Organic and Biomolecular Chemistry 2008, 6(13), 2233 - 2241, 10.1039/b803664k .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Klepetarova, Blanka;
Kuchar, Martin, Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations. Organic and Biomolecular Chemistry 2008, 6(13), 2377 - 2387, 10.1039/b802833h .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Vrabel, Milan;
Ernsting, Nikolaus P.;
Sajadi, Mohsen;
Kovalenko, Sergey A., Synthesis and photophysical properties of 7-deaza-2′-deoxyadenosines bearing bipyridine ligands and their Ru(ii)-complexes in position 7. Organic and Biomolecular Chemistry 2008, 6(16), 2852 - 2860, 10.1039/b805632c .
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Hocek, Michal;
Pohl, Radek;
Cahova, Hana;
Bednarova, Lucie;
Novakova, Katerina;
Cvacka, Josef, Synthesis of 8-bromo-, 8-methyl- and 8-phenyl-dATP and their polymerase incorporation into DNA. Organic and Biomolecular Chemistry 2008, 6(20), 3657 - 3660, 10.1039/b811935j .
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Hocek, Michal;
Havran, Ludek;
Fojta, Miroslav;
Rulisek, Lubomir;
Zendlova, Lucie;
Srnec, Martin;
Chalupsky, Jakub;
Kyvala, Mojmir, Effect of spin-orbit coupling on reduction potentials of octahedral ruthenium(II/III) and osmium(II/III) complexes. Journal of the American Chemical Society 2008, 130(33), 10947 - 10954, 10.1021/ja800616s .
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Hocek, Michal;
Pohl, Radek;
Havran, Ludek;
Fojta, Miroslav;
Cahova, Hana;
Brazdilova, Petra;
Pivonkova, Hana, Aminophenyl- and nitrophenyl-labeled nucleoside triphosphates: Synthesis, enzymatic incorporation, and electrochemical detection. Angewandte Chemie - International Edition 2008, 47(11), 2059 - 2062, 10.1002/anie.200705088 .
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Naus, Petr;
Hocek, Michal;
Kuchar, Martin, Cytostatic and antiviral 6-arylpurine ribonucleosides IX. Synthesis and evaluation of 6-substituted 3-deazapurine ribonucleosides. Collect. Czech. Chem. Commun. 2008, 73(5), 665 - 678, 10.1135/cccc20080665 .
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Hocek, Michal;
Pohl, Radek;
Urban, Milan;
Joubert, Nicolas, Modular Synthesis of 4-aryl- and 4-amino-substituted benzene C-2′-Deoxyribonucleosides. Synthesis 2008(12), 1918 - 1932, 10.1055/s-2008-1067038 .
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Kotora, Martin;
Hocek, Michal;
Turek, Pavel;
Pohl, Radek;
Klepetarova, Blanka, Cobalt-induced synthesis of 6-(pyridin-2-yl)purines by microwave-enhanced [2+2+2] cyclotrimerization. European Journal of Organic Chemistry 2008(19), 3335 - 3343, 10.1002/ejoc.200800205 .
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Hocek, Michal;
Pohl, Radek;
Bambuch, Vitezslav, Synthesis of 6-(4,5-dihydrofuran-2-yl)- and 6-(tetrahydrofuran-2-yl)purine bases and nucleosides. European Journal of Organic Chemistry 2008(16), 2783 - 2788, 10.1002/ejoc.200800174 .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Stefko, Martin, A modular methodology for the synthesis of 4- and 3-substituted benzene and aniline C-ribonucleosides. European Journal of Organic Chemistry 2008(10), 1689 - 1704, 10.1002/ejoc.200701168 .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Cerna, Igor, Synthesis of 6,8,9-tri- and 2,6,8,9-tetrasubstituted purines by a combination of the Suzuki cross-coupling, N-arylation, and direct C-H arylation reactions. Journal of Organic Chemistry 2008, 73(22), 9048 - 9054, 10.1021/jo8018126 .
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Hocek, Michal;
Klecka, Martin;
Pohl, Radek;
Klepetaova, Blanka, Direct C-H borylation and C-H arylation of pyrrolo2,3-dpyrimidines: Synthesis of 6,8-disubstituted 7-deazapurines. Organic and Biomolecular Chemistry 2009, 7(5), 866 - 868, 10.1039/b900218a .
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Hocek, Michal;
Pohl, Radek;
Vrabel, Milan;
Havran, Ludek;
Fojta, Miroslav;
Cahova, Hana;
Horakova, Petra;
Pivonkovas, Hana;
Kalachova, Lubica;
Cernocka, Hana;
Sebest, Peter, Base-modified DNA labeled by [Ru(bpy)] and [Os(bpy)] complexes: Construction by polymerase incorporation of modified nucleoside triphosphates, electrochemical and luminescent properties, and applications. Chemistry - A European Journal 2009, 15(5), 1144 - 1154, 10.1002/chem.200801538 .
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Hocek, Michal;
Pohl, Radek;
Kalachova, Lubica, Synthesis of 2′-deoxyuridine and 2′-deoxycytidine Nucleosides bearing bipyridine and terpyridine ligands at position 5. Synthesis 2009(1), 105 - 112, 10.1055/s-0028-1083266 .
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Hocek, Michal;
Pohl, Radek;
Stefko, Martin, Synthesis of benzamide-C-ribonucleosides by Pd-catalyzed aminocarbonylations. Tetrahedron 2009, 65(23), 4471 - 4483, 10.1016/j.tet.2009.04.006 .
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Hocek, Michal;
Pohl, Radek;
Havran, Ludek;
Fojta, Miroslav;
Horakova, Petra;
Sebest, Peter;
Riedl, Jan, Tetrathiafulvalene-labelled nucleosides and nucleoside triphosphates: Synthesis, electrochemistry and the scope of their polymerase incorporation into DNA. European Journal of Organic Chemistry 2009(21), 3519 - 3525, 10.1002/ejoc200900392 .
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Hocek, Michal;
Pohl, Radek;
Cernova, Miroslava, Switching the regioselectivity of direct C-H arylation of 1,3-Dimethyluracil. European Journal of Organic Chemistry 2009(22), 3698 - 3701, 10.1002/ejoc.200900586 .
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Hocek, Michal;
Pohl, Radek;
Hasnik, Zbynek, Cross-coupling reactions of halopurines with aryl- and alkyltrifluoroborates; the scope and limitations in the synthesis of modified purines. Synthesis 2009(8), 1309 - 1317, 10.1055/s-0028-1088038 .
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Kotora, Martin;
Hocek, Michal;
Bobula, Tomas, Sonogashira reactions of α- and β-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides. Tetrahedron 2010, 66(2), 530 - 536, 10.1016/j.tet.2009.11.030 .
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Hocek, Michal;
Reha, David;
Hobza, Pavel;
Zendlova, Lucie, Theoretical study of the stability of the DNA duplexes modified by a series of hydrophobic base analogues. Chemistry - A European Journal 2009, 15(31), 7601 - 7610, 10.1002/chem.200802170 .
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Hocek, Michal;
Klepetarova, Blanka;
Stefko, Martin;
Slavetinska, Lenka, A general and efficient synthesis of pyridin-2-yl C-ribonucleosides bearing diverse alkyl, aryl, amino, and carbamoyl groups in position 6. Journal of Organic Chemistry 2010, 75(2), 442 - 449, 10.1021/jo902313g .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Hasnik, Zbynek, Synthesis of (purin-6-yl)acetates and their transformations to 6-(2-hydroxyethyl)-and 6-(carbamoylmethyl)purines. Collect. Czech. Chem. Commun. 2009, 74(7-8), 1035 - 1059, 10.1135/cccc2009042 .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Mackman, Richard;
Dzubak, Petr;
Hajduch, Marian;
Ameral, Ria;
Birkus, Gabriel;
Wang, Ting;
Ray, Adrian S.;
Cihlar, Tomas, 6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents. Journal of Medicinal Chemistry 2010, 53(1), 460 - 470, 10.1021/jm901428k .
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Sanda, Miloslav;
Hocek, Michal;
Pohl, Radek;
Raindlova, Veronika, Direct polymerase synthesis of reactive aldehyde-functionalized DNA and Its conjugation and staining with hydrazines. Angewandte Chemie - International Edition 2010, 49(6), 1064 - 1066, 10.1002/anie.200905556 .
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Hocek, Michal;
Pohl, Radek;
Ikonen, Satu;
MacIkova-Cahova, Hana;
Anda, Miloslav, Synthesis of nucleoside and nucleotide conjugates of bile acids, and polymerase construction of bile acid-functionalized DNA. Organic and Biomolecular Chemistry 2010, 8(5), 1194 - 1201, 10.1039/b924072a .
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Hocek, Michal;
Pohl, Radek;
Hasnik, Zbynek, Synthesis of (purin-6-yl)methylphosphonate bases and nucleosides. Tetrahedron Letters 2010, 51(18), 2464 - 2466, 10.1016/j.tetlet.2010.02.167 .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Cerna, Igor, Intramolecular direct C-H arylation approach to fused purines. Synthesis of purino[8, 9-f]phenanthridines and 5, 6-dihydropurino[8, 9-a]isoquinolines. Journal of Organic Chemistry 2010, 75(7), 2302 - 2308, 10.1021/jo100111t .
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Hocek, Michal;
Klepetarova, Blanka;
Slavetinska, Lenka;
Kubelka, Tomas, Synthesis of 2,4-disubstituted pyrimidin-5-yl C-2′- deoxyribonucleosides by sequential regioselective reactions of 2,4-dichloropyrimidine nucleosides. European Journal of Organic Chemistry 2010(14), 2666 - 2669, 10.1002/ejoc.201000164 .
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Hocek, Michal;
Marek, Radek;
Malinakova, Katerina;
Kristkova, Anezka;
Tousek, Jaromir;
Marek, Jaromir;
Malkina, Olga L.;
Malkin, Vladimir G., Interpretation of indirect nuclear spin-spin couplings in isomers of adenine: Novel approach to analyze coupling electron deformation density using localized molecular orbitals. Journal of Physical Chemistry A 2010, 114(24), 6689 - 6700, 10.1021/jp102186r .
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Hocek, Michal;
Urban, Milan;
Joubert, Nicolas;
Purse, Byron W.;
Kuchta, Robert D., Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate. Biochemistry 2010, 49(4), 727 - 735, 10.1021/bi9019516 .
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Hocek, Michal;
Klepetarova, Blanka;
Barta, Jan;
Slavetinska, Lenka, Modular synthesis of 5-substituted furan-2-yl C-2'-deoxyribonudeosides and biaryl covalent base-pair analogues. European Journal of Organic Chemistry 2010(28), 5432 - 5443, 10.1002/ejoc.201000726 .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Ameral, Ria;
Birkus, Gabriel;
Cihlar, Tomas;
Spacilova, Pavla;
Snasel, Jan;
Zabranska, Helena;
Pichova, Iva, CycloSal-phosphate pronucleotides of cytostatic 6-(het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases. ChemMedChem 2010, 5(8), 1386 - 1396, 10.1002/cmdc.201000192 .
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Hocek, Michal;
Stefko, Martin, Synthesis of phenol and pyridone C -ribo- and 2-deoxyribonucleosides by palladium-catalyzed hydroxylations of haloaryl C -nucleosides. Synthesis 2010(24), 4199 - 4206, 10.1055/s-0030-1258318 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Birkus, Gabriel;
Cihlar, Tomas;
Perlikova, Pavla;
Shih, Robert, Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides. Bioorganic and Medicinal Chemistry 2011, 19(1), 229 - 242, 10.1016/j.bmc.2010.11.029 .
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Hocek, Michal;
Fojta, Miroslav;
Horakova, Petra;
MacIkova-Cahova, Hana;
Pivokova, Hana;
Paek, Jan;
Havran, Ludk, Tail-labelling of DNA probes using modified deoxynucleotide triphosphates and terminal deoxynucleotidyl tranferase. Application in electrochemical DNA hybridization and protein-DNA binding assays. Organic and Biomolecular Chemistry 2011, 9(5), 1366 - 1371, 10.1039/c0ob00856g .
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Hocek, Michal;
Pohl, Radek;
Havran, Ludek;
Fojta, Miroslav;
Horakova, Petra;
Macickova-Cahova, Hana;
Spacek, Jan, Alkylsulfanylphenyl derivatives of cytosine and 7-deazaadenine nucleosides, nucleotides and nucleoside triphosphates: Synthesis, polymerase incorporation to DNA and electrochemical study. Chemistry - A European Journal 2011, 17(21), 5833 - 5841, 10.1002/chem.201003496 .
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Hocek, Michal;
Pohl, Radek;
Kielkowski, Pavel, Synthesis of acetylene linked double-nucleobase nucleos(t)ide building blocks and polymerase construction of DNA containing cytosines in the major groove. Journal of Organic Chemistry 2011, 76(9), 3457 - 3462, 10.1021/jo200436j .
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Hocek, Michal;
Stevens, Kristof;
Claeys, Diederica D.;
Catak, Saron;
Figaroli, Sara;
Tromp, Jan M.;
Schuerch, Stefan;
Speybroeck, Veronique Van;
Madder, Annemieke, Furan-oxidation-triggered inducible DNA cross-linking: Acyclic versus cyclic furan-containing building blocks - On the benefit of restoring the cyclic sugar backbone. Chemistry - A European Journal 2011, 17(25), 6940 - 6953, 10.1002/chem.201100067 .
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Hocek, Michal;
Pohl, Radek;
Cerna, Igor;
Cernova, Miroslava, Regioselective direct C-H arylations of protected uracils. Synthesis of 5- and 6-aryluracil bases. Journal of Organic Chemistry 2011, 76(13), 5309 - 5319, 10.1021/jo2006494 .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Dzubak, Petr;
Hajduch, Marian;
Birkus, Gabriel;
Wang, Ting;
Ray, Adrian S.;
Cihlar, Tomas;
Pichova, Iva;
Perlikova, Pavla;
Bourderioux, Aurelie;
Konecny, Petr;
Stray, Kirsten M.;
Feng, Joy Y., Synthesis and significant cytostatic activity of 7-hetaryl-7- deazaadenosines. Journal of Medicinal Chemistry 2011, 54(15), 5498 - 5507, 10.1021/jm2005173 .
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Kotora, Martin;
Hocek, Michal;
Neas, David;
Hidasova, Denisa, Modular synthesis of 1-α- and 1-β-(indol-2-yl)-2′- deoxyribose C-nucleosides. Organic and Biomolecular Chemistry 2011, 9(17), 5934 - 5937, 10.1039/c1ob05844d .
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Hocek, Michal;
Pohl, Radek;
Macickova-Cahova, Hana;
Kielkowski, Pavel, Transient and switchable (Triethylsilyl)ethynyl protection of DNA against cleavage by restriction endonucleases. Angewandte Chemie - International Edition 2011, 50(37), 8727 - 8730, 10.1002/anie.201102898 .
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Malkov, Andrei V.;
Kocovsky, Pavel;
Hocek, Michal;
Stambasky, Jan;
Stefko, Martin;
Kapras, Votech;
Kysilka, Ondrej, A modular approach to aryl-C-ribonucleosides via the allylic substitution and ring-closing metathesis sequence. A stereocontrolled synthesis of all four α-/β- and D-/L-C-nucleoside stereoisomers. Journal of Organic Chemistry 2011, 76(19), 7781 - 7803, 10.1021/jo201110z .
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Hocek, Michal;
Pohl, Radek;
Havran, Ludek;
Fojta, Miroslav;
Horakova, Petra;
Balintova, Jana;
Vidlakova, Pavlina, Anthraquinone as a redox label for DNA: Synthesis, enzymatic incorporation, and electrochemistry of anthraquinone-modified nucleosides, nucleotides, and DNA. Chemistry - A European Journal 2011, 17(50), 14063 - 14073, 10.1002/chem.201101883 .
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Hocek, Michal;
Pohl, Radek;
Kalachova, Lubica, Synthesis of nucleoside mono- and triphosphates bearing oligopyridine ligands, their incorporation into DNA and complexation with transition metals. Organic and Biomolecular Chemistry 2012, 10(1), 49 - 55, 10.1039/c1ob06359f .
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Hocek, Michal;
Pohl, Radek;
Rulisek, Lubomir;
Riedl, Jan, Synthesis and photophysical properties of biaryl-substituted nucleos(t)ides. Polymerase synthesis of DNA probes bearing solvatochromic and pH-sensitive dual fluorescent and F NMR labels. Journal of Organic Chemistry 2012, 77(2), 1026 - 1044, 10.1021/jo202321g .
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Hocek, Michal;
Kubelka, Toma;
Slavtinska, Lenka, A general regioselective approach to 2,4-disubstituted pyrimidin-5-yl C-2-deoxyribonucleosides. Synthesis 2012, 44(6), 953 - 965, 10.1055/s-0031-1289694 .
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Hocek, Michal;
Pohl, Radek;
Joubert, Nicolas;
Kubelka, Tomas;
Chapuis, Hubert, Synthesis of 6-substituted 2(1H)-pyridon-3-yl C-2′- deoxyribonucleosides. European Journal of Organic Chemistry 2012(9), 1759 - 1767, 10.1002/ejoc.201101662 .
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Hocek, Michal;
Pohl, Radek;
Raindlova, Veronika, Synthesis of aldehyde-linked nucleotides and DNA and their bioconjugations with lysine and peptides through reductive amination. Chemistry - A European Journal 2012, 18(13), 4080 - 4087, 10.1002/chem.201103270 .
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Naus, Petr;
Hocek, Michal;
Pohl, Radek;
Perlikova, Pavla, Sugar-modified derivatives of cytostatic 6-(het)aryl-7-deazapurine nucleosides: 2′-c-methylribonucleosides, arabinonucleosides and 2′-deoxy-2′-fluoroarabinonucleosides. Collect. Czech. Chem. Commun. 2011, 76(8), 957 - 988, 10.1135/cccc2011082 .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Cernova, Miroslava, A general regioselective synthesis of 2,4-diarylpyrimidines from 2-thiouracil through two orthogonal cross-coupling reactions. Synlett 2012, 23(9), 1305 - 1308, 10.1055/s-0031-1290826 .
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Hocek, Michal;
Urban, Milan;
Joubert, Nicolas;
Kuchta, Robert D.;
Lund, Travis J.;
Cavanaugh, Nisha A.;
Patro, Jennifer N., B family DNA polymerases asymmetrically recognize pyrimidines and purines. Biochemistry 2011, 50(33), 7243 - 7250, 10.1021/bi2006916 .
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Menova, Petra;
Hocek, Michal, Preparation of short cytosine-modified oligonucleotides by nicking enzyme amplification reaction. Chemical Communications 2012, 48(55), 6921 - 6923, 10.1039/c2cc32930a .
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Hocek, Michal;
Perlikova, Pavla;
Slavtinska, Lenka;
Jornet Martinez, Neus, Synthesis of 2′-deoxy-2′-fluororibo- and 2′-deoxy- 2′,2′-difluororibonucleosides derived from 6-(het)aryl-7- deazapurines. Tetrahedron 2012, 68(39), 8300 - 8310, 10.1016/j.tet.2012.07.033 .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Slavetinska, Lenka;
Birkus, Gabriel;
Cihlar, Tomas;
Perlikova, Pavla;
Bourderioux, Aurelie;
Bahador, Gina, Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′- fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides. Bioorganic and Medicinal Chemistry 2012, 20(17), 5202 - 5214, 10.1016/j.bmc.2012.07.003 .
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Hocek, Michal;
Pohl, Radek;
Tichy, Michal;
Xu, Hao Ying;
Chen, Yen-Liang;
Yokokawa, Fumiaki;
Shi, Pei-Yong, Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides. Bioorganic and Medicinal Chemistry 2012, 20(20), 6123 - 6133,11, 10.1016/j.bmc.2012.08.021 .
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Kuchta, Robert D.;
Beckman, Jeff;
Kincaid, Kristi;
Spratt, Thomas;
Engels, Joachim;
Cosstick, Richard, Human DNA polymerase α uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity. Biochemistry 2007, 46(2), 448 - 460, 10.1021/bi061243s .
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Hocek, Michal;
Silhar, Peter, Palladium-catalyzed cross-coupling reactions in c6 modifications of purine nucleosides.. Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2007, Chapter 1, Unit 1.16.
Hocek, Michal;
Joubert, Nicolas;
Hari, Yoshiyuki;
Hwang, Gil Tae;
Leconte, Aaron M;
Romesberg, Floyd E, Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication.. Chembiochem : a European journal of chemical biology 2008, 9(17), 2796 - 2799, 10.1002/cbic.200800577 .
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Hocek, Michal;
Vrabel, Milan;
Havran, Ludek;
Fojta, Miroslav;
Cahova, Hana;
Pivonkova, Hana;
Horakova, Petra;
Kalachova, Lubica;
Riedl, Jan, Novel base-functionalized DNA. Efficient methodology for construction and bioanalytical applications.. Nucleic acids symposium series (2004) 2008(52), 53 - 54.
Kotora, Martin;
Hocek, Michal;
Turek, Pavel, 6-Aryl- and 6-heteroarylpurines via cyclotrimerization.. Nucleic acids symposium series (2004) 2008(52), 533 - 534.
Hocek, Michal;
Urban, Milan;
Joubert, Nicolas;
Kuchta, Robert D.;
Alexander, Richard E., Herpes simplex virus-1 DNA primase: A remarkably inaccurate yet selective polymerase. Biochemistry 2009, 48(46), 10866 - 10881, 10.1021/bi901476k .
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Hocek, Michal;
Macickova-Cahovthoma, Hana, Cleavage of adenine-modified functionalized DNA by type II restriction endonucleases. Nucleic Acids Research 2009, 37(22), 7612 - 7622, 10.1093/nar/gkp845 .
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Kocovsky, Pavel;
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Stambasky, Jan, C-Nucleosides: Synthetic Strategies and Biological Applications. Chemical Reviews 2009, 109(12), 6729 - 6764, 10.1021/cr9002165 .
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Hocek, Michal;
Marek, Radek;
Marek, Jaromir;
Standara, Stanislav;
Maliakova, Kateina;
Vaara, Juha;
Straka, Michal, Understanding the NMR chemical shifts for 6-halopurines: Role of structure, solvent and relativistic effects. Physical Chemistry Chemical Physics 2010, 12(19), 5126 - 5139, 10.1039/b921383j .
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Hocek, Michal;
Pohl, Radek;
Macickova-Cahova, Hana, Cleavage of Functionalized DNA Containing 5-Modified Pyrimidines by Type II Restriction Endonucleases. Chembiochem : a European journal of chemical biology 2011, 12(3), 431 - 438, 10.1002/cbic.201000644 .
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Hocek, Michal;
Marek, Radek;
Marek, Jaromir;
Standara, Stanislav;
Straka, Michal;
Bouzkova, Katerina;
Zacharova, Zuzana, Interpretation of substituent effects on C and N NMR chemical shifts in 6-substituted purines. Physical Chemistry Chemical Physics 2011, 13(35), 15854 - 15864, 10.1039/c1cp20680j .
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Hocek, Michal;
Havran, Ludek;
Fojta, Miroslav;
Pivonkova, Hana;
Horakova, Petra, Redox labels and indicators based on transition metals and organic electroactive moieties for electrochemical nucleic acids sensing. Current Organic Chemistry 2011, 15(17), 2936 - 2942.
Hocek, Michal;
Pohl, Radek;
Fojta, Miroslav;
Ernsting, Nikolaus P.;
Riedl, Jan;
Orsag, Petr, Labelling of nucleosides and oligonucleotides by solvatochromic 4-aminophthalimide fluorophore for studying DNA-protein interactions. Chemical Science 2012, 3(9), 2797 - 2806, 10.1039/c2sc20404e .
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Hocek, Michal;
Slavetinska, Lenka;
Kubelka, Tomas, Synthesis of substituted benzyl homo-C-ribonucleosides and -nucleotides as carba analogues of phosphoribosylanthranilate. European Journal of Organic Chemistry 2012(26), 4969 - 4981, 10.1002/ejoc.201200819 .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Havran, Ludek;
Fojta, Miroslav;
Pivonkova, Hana;
Horakova, Petra;
Raindlova, Veronika;
Simkov, Eva, Synthesis of hydrazone-modified nucleotides and their polymerase incorporation onto DNA for redox labeling. ChemPlusChem 2012, 77(8), 652 - 662, 10.1002/cplu.201200056 .
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Menova, Petra;
Hocek, Michal;
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Fojta, Miroslav;
Riedl, Jan;
Orsag, Petr, GFP-like fluorophores as DNA labels for studying DNA-protein interactions. Journal of Organic Chemistry 2012, 77(18), 8287 - 8293, 10.1021/jo301684b .
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Hocek, Michal;
Pohl, Radek;
Bednarova, Lucie;
Kalachova, Lubica;
Fanfrlik, Jindrich, Synthesis of nucleosides and dNTPs bearing oligopyridine ligands linked through an octadiyne tether, their incorporation into DNA and complexation with transition metal cations. Organic and Biomolecular Chemistry 2013, 11(1), 78 - 89, 10.1039/c2ob26881g .
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Hocek, Michal;
Kielkowski, Pavel;
Brock, Nelson L.;
Dickschat, Jeroen S., Nucleobase Protection Strategy for Gene Cloning and Expression. Chembiochem : a European journal of chemical biology 2013, 14(7), 801 - 804, 10.1002/cbic.201300127 .
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Menova, Petra;
Hocek, Michal;
Havran, Ludek;
Fojta, Miroslav;
Cahova, Hana;
Plucnara, Medard, Polymerase synthesis of oligonucleotides containing a single chemically modified nucleobase for site-specific redox labelling. Chemical Communications 2013, 49(41), 4652 - 4654, 10.1039/c3cc41438h .
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Eigner, Vaclav;
Hocek, Michal;
Slavetinska, Lenka;
Kubelka, Tomas, Synthesis of 2,6-disubstituted pyridin-3-yl C-2′-deoxyribonucleosides through chemoselective transformations of bromo-chloropyridine C-nucleosides. Organic and Biomolecular Chemistry 2013, 11(28), 4702 - 4718, 10.1039/c3ob40774h .
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Menova, Petra;
Hocek, Michal;
Raindlova, Veronika, Scope and limitations of the nicking enzyme amplification reaction for the synthesis of base-modified oligonucleotides and primers for PCR. Bioconjugate Chemistry 2013, 24(6), 1081 - 1093, 10.1021/bc400149q .
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Cejka, Jan;
Hocek, Michal;
Klecka, Martin;
Pohl, Radek, Direct C-H sulfenylation of purines and deazapurines. Organic and Biomolecular Chemistry 2013, 11(31), 5189 - 5193, 10.1039/c3ob40881g .
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Menova, Petra;
Hocek, Michal;
Slavetinska, Lenka;
Raindlova, Veronika;
Perlikova, Pavla;
Bahador, Gina;
Eberlin, Ludovic;
Tloustova, Eva;
Lee, Yu-Jen, Synthesis and Cytostatic and Antiviral Activities of 2′-Deoxy-2′,2′-difluororibo- and 2′-Deoxy-2′-fluororibonucleosides Derived from 7-(Het)aryl-7-deazaadenines. ChemMedChem 2013, 8(5), 832 - 846, 10.1002/cmdc.201300047 .
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Hocek, Michal;
Pohl, Radek;
Bahador, Gina;
Tichy, Michal;
Lee, Yu-Jen;
Tloust'Ova, Eva;
Weber, Jan, Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides. Bioorganic and Medicinal Chemistry 2013, 21(17), 5362 - 5372, 10.1016/j.bmc.2013.06.011 .
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Hocek, Michal;
Pohl, Radek;
Havran, Ludek;
Fojta, Miroslav;
Balintova, Jana;
Vidlakova, Pavlina;
Plucnara, Medard, Benzofurazane as a new redox label for electrochemical detection of DNA: Towards multipotential redox coding of DNA bases. Chemistry - A European Journal 2013, 19(38), 12720 - 12731, 10.1002/chem.201301868 .
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Dadova, Jitka;
Hocek, Michal;
Pohl, Radek;
Fojta, Miroslav;
Orsag, Petr;
Brazdova, Marie, Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins. Angewandte Chemie - International Edition 2013, 52(40), 10515 - 10518, 10.1002/anie.201303577 .
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Dadova, Jitka;
Hocek, Michal;
Pohl, Radek;
Havran, Ludek;
Fojta, Miroslav;
Vidlakova, Pavlina, Aqueous heck cross-coupling preparation of acrylate-modified nucleotides and nucleoside triphosphates for polymerase synthesis of acrylate-labeled DNA. Journal of Organic Chemistry 2013, 78(19), 9627 - 9637, 10.1021/jo4011574 .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Dzubak, Petr;
Hajduch, Marian;
Snasel, Jan;
Pichova, Iva;
Perlikova, Pavla;
Konecny, Petr, 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents. MedChemComm 2013, 4(11), 1497 - 1500, 10.1039/c3md00232b .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Klepetarova, Blanka;
Vrabel, Milan, Synthesis of 2′-deoxyadenosine nucleosides bearing bipyridine-typeligands and their Ru-complexes in position 8 through cross-coupling rea ctions. Organic and Biomolecular Chemistry.
Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Havran, Ludek;
Fojta, Miroslav;
Pivonkova, Hana;
Horakova, Petra;
Raindlova, Veronika;
Simkova, Eva, Synthesis of hydrazone-modified nucleotides and their polymerase incorporation onto DNA for redox labeling. Collection of Czechoslovak Chemical Communications 2012, 77(8), 652 - 662.
Naus, Petr;
Hocek, Michal;
Slavetinska, Lenka;
Dzubak, Petr;
Hajduch, Marian;
Perlikova, Pavla;
Konecny, Petr;
Tloust'Ova, Eva;
Caletkova, Olga;
Bogdanova, Katerina;
Kolar, Milan;
Vrbkova, Jana, Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides. Journal of Medicinal Chemistry 2014, 57(3), 1097 - 1110, 10.1021/jm4018948 .
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Hocek, Michal;
Havran, Ludek;
Fojta, Miroslav;
Raindlova, Veronika;
Danhel, Ales;
Barek, Jiri, Voltammetric Study of dsDNA Modified by Multi-redox Label Based on N-methyl-4-hydrazino-7-nitrobenzofurazan. Electrochimica Acta 2014, 129, 348 - 357, 10.1016/j.electacta.2014.02.137 .
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Hocek, Michal;
Havran, Ludek;
Fojta, Miroslav;
Pivonkova, Hana;
Raindlova, Veronika;
Danhel, Ales, Electrochemical behaviour of 2,4-dinitrophenylhydrazi(o)ne as multi-redox centre DNA label at mercury meniscus modified silver solid amalgam electrode. Electrochimica Acta 2014, 126, 122 - 131, 10.1016/j.electacta.2013.09.147 .
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Hocek, Michal;
Pohl, Radek;
Klepetarova, Blanka;
Cernova, Miroslava, C-H trifluoromethylations of 1,3-dimethyluracil and reactivity of the products in C-H arylations. Heterocycles 2014, 89(5), 1159 - 1171, 10.3987/COM-14-12958 .
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Patents
Hocek, Michal;
Votruba, Ivan;
HOLandYacute, NOVEL 6-PHENYLPURINE 9-'beta'-D-RIBONUCLEOSIDES WITH ANTINEOPLASTIC ACTIVITY, THEIR USE FOR PREPARING PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH COMPOUNDS, WO2000/75158, 2000.
Hocek, Michal;
CAPEK Petr, (PURIN-6-YL) AMINO ACID AND PRODUCTION METHOD THEREOF, WO2004/94426, 2004.
Naus, Petr;
Hocek, Michal;
Bourderioux, Aurelie, NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES, WO2010/121576, 2010.