Votruba, Ivan
Articles
Cisarova, Ivana;
Dvorakova, Hana;
Dvorak, Dalimil;
Krovacek, Martin;
Votruba, Ivan, 6-alkynylpurines bearing electronacceptor substituents: Preparation, reactivity in cycloaddition reactions and cytostatic activity. Collect. Czech. Chem. Commun. 2011, 76(12), 1487 - 1507, 10.1135/cccc2011176 
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Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan;
Hockova, Dana, Synthesis and cytostatic activity of nucleosides and acyclic nucleoside analogues derived from 6-(trifluoromethyl)purines. Tetrahedron 1999, 55(36), 11109 - 11118, 10.1016/S0040-4020(99)00615-8 .
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Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: Application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids. Journal of Medicinal Chemistry 2000, 43(9), 1817 - 1825, 10.1021/jm991167+ .
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Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-β-D-erythro-pentofuranosyl)-, 9-(5-deoxy-β-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines. Collect. Czech. Chem. Commun. 2000, 65(11), 1683 - 1697.
Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl-and 6-benzylpurine ribonucleosides. Collect. Czech. Chem. Commun. 2001, 66(3), 483 - 499, 10.1135/cccc20010483 .
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Hocek, Michal;
Votruba, Ivan, Covalent analogues of DNA base-pairs and triplets. Part 2: Synthesis and cytostatic activity of bis(purin-6-yl)acetylenes, -diacetylenes and related compounds. Bioorganic and Medicinal Chemistry Letters 2002, 12(7), 1055 - 1058, 10.1016/S0960-894X(02)00077-X .
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Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Synthesis of carba-analogues of myoseverin by regioselective cross-coupling reactions of 2,6-dichloro-9-isopropylpurine. Tetrahedron 2003, 59(5), 607 - 611, 10.1016/S0040-4020(02)01586-7 .
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Cisarova, Ivana;
Ludvik, Jiri;
Hocek, Michal;
Stepnicka, Petr;
Votruba, Ivan;
Reha, David;
Hobza, Pavel, Ferrocene-Modified Purines as Potential Electrochemical Markers: Synthesis, Crystal Structures, Electrochemistry and Cytostatic Activity of (Ferrocenylethynyl)- and (Ferrocenylethyl)purines. Chemistry - A European Journal 2004, 10(8), 2058 - 2066, 10.1002/chem.200305621 .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan, Covalent analogues of DNA base-pairs and triplets VII. synthesis and cytostatic activity of bis(purin-6-yl)acetylene and -diacetylene nucleosides. Collect. Czech. Chem. Commun. 2004, 69(10), 1955 - 1970, 10.1135/cccc20041955 .
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Cisarova, Ivana;
Tislerova, Iva;
Kotora, Martin;
Hocek, Michal;
Votruba, Ivan;
Turek, Pavel, Cocyclotrimerization of 6-alkynylpurines with α,ω-diynes as a novel approach to biologically active 6-arylpurines. Journal of Organic Chemistry 2004, 69(26), 9224 - 9233, 10.1021/jo0486342 .
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Kotora, Martin;
Hocek, Michal;
Votruba, Ivan;
Turek, Pavel, Novel method for preparation of highly substituted 6-arylpurines by reactions of 6-alkynylpurines with zirconacyclopentadienes. Collect. Czech. Chem. Commun. 2005, 70(3), 339 - 349, 10.1135/cccc20050339 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Silhar, Peter, Facile and efficient synthesis of 6-(hydroxymethyl)purines. Organic Letters 2004, 6(19), 3225 - 3228, 10.1021/ol049059r .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Furman, Phillip A.;
Tharnish, Phillip M.;
Otto, Michael J., Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides. Journal of Medicinal Chemistry 2005, 48(18), 5869 - 5873, 10.1021/jm050335x .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Silhar, Peter, The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides. Organic and Biomolecular Chemistry 2005, 3(16), 3001 - 3007, 10.1039/b508122j .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Silhar, Peter, Synthesis of 2-substituted 6-(hydroxymethyl)purine bases and nucleosides. Collect. Czech. Chem. Commun. 2005, 70(10), 1669 - 1695, 10.1135/cccc20051669 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Kuchar, Martin, Synthesis of purines bearing functionalized C-substituents by the conjugate addition of nucleophiles to 6-vinylpurines and 6-ethynylpurines. European Journal of Organic Chemistry 2006(22), 5083 - 5098, 10.1002/ejoc.200600545 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Silhar, Peter, Synthesis and cytostatic activity of novel 6-(Difluoromethyl)purine bases and nucleosides. Synthesis 2006(11), 1848 - 1852, 10.1055/s-2006-942365 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Klepetarova, Blanka;
Silhar, Peter, Synthesis of 6-amino-, 6-methyl- and 6-aryl-2-(hydroxymethyl)purine bases and nucleosides. Collect. Czech. Chem. Commun. 2006, 71(6), 788 - 803, 10.1135/cccc20060788 .
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Hocek, Michal;
Votruba, Ivan;
Hobza, Pavel;
Pohl, Radek;
Klepetarova, Blanka;
Mabery, Eric;
Mackman, Richard;
Vrabel, Milan;
Havran, Ludek;
Fojta, Miroslav;
Rulisek, Lubomir;
Zendlova, Lucie;
Shih, I.-Hung, Purines bearing phenanthroline or bipyridine ligands and their RuII complexes in position 8 as model compounds for electrochemical DNA labeling - Synthesis, crystal structure, electrochemistry, quantum chemical calculations, cytostatic and antiviral activity. European Journal of Inorganic Chemistry 2007(12), 1752 - 1769, 10.1002/ejic.200700030 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Klepetarova, Blanka;
Vrabel, Milan, Synthesis of 2′-deoxyadenosine nucleosides bearing bipyridine-type ligands and their Ru-complexes in position 8 through cross-coupling reactions. Organic and Biomolecular Chemistry 2007, 5(17), 2849 - 2857, 10.1039/b709245h .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Shih, I-hung;
Mabery, Eric;
Mackman, Richard;
Kuchar, Martin, Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides. Bioorganic and Medicinal Chemistry 2008, 16(3), 1400 - 1424, 10.1016/j.bmc.2007.10.063 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Silhar, Peter;
Shih, I-hung;
Mabery, Eric;
Mackman, Richard, Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides. Bioorganic and Medicinal Chemistry 2008, 16(5), 2329 - 2366, 10.1016/j.bmc.2007.11.067 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Klepetarova, Blanka;
Kuchar, Martin, Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations. Organic and Biomolecular Chemistry 2008, 6(13), 2377 - 2387, 10.1039/b802833h .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Vrabel, Milan;
Ernsting, Nikolaus P.;
Sajadi, Mohsen;
Kovalenko, Sergey A., Synthesis and photophysical properties of 7-deaza-2′-deoxyadenosines bearing bipyridine ligands and their Ru(ii)-complexes in position 7. Organic and Biomolecular Chemistry 2008, 6(16), 2852 - 2860, 10.1039/b805632c .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Mackman, Richard;
Dzubak, Petr;
Hajduch, Marian;
Ameral, Ria;
Birkus, Gabriel;
Wang, Ting;
Ray, Adrian S.;
Cihlar, Tomas, 6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents. Journal of Medicinal Chemistry 2010, 53(1), 460 - 470, 10.1021/jm901428k .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Ameral, Ria;
Birkus, Gabriel;
Cihlar, Tomas;
Spacilova, Pavla;
Snasel, Jan;
Zabranska, Helena;
Pichova, Iva, CycloSal-phosphate pronucleotides of cytostatic 6-(het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases. ChemMedChem 2010, 5(8), 1386 - 1396, 10.1002/cmdc.201000192 .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Birkus, Gabriel;
Cihlar, Tomas;
Perlikova, Pavla;
Shih, Robert, Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides. Bioorganic and Medicinal Chemistry 2011, 19(1), 229 - 242, 10.1016/j.bmc.2010.11.029 .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Dzubak, Petr;
Hajduch, Marian;
Birkus, Gabriel;
Wang, Ting;
Ray, Adrian S.;
Cihlar, Tomas;
Pichova, Iva;
Perlikova, Pavla;
Bourderioux, Aurelie;
Konecny, Petr;
Stray, Kirsten M.;
Feng, Joy Y., Synthesis and significant cytostatic activity of 7-hetaryl-7- deazaadenosines. Journal of Medicinal Chemistry 2011, 54(15), 5498 - 5507, 10.1021/jm2005173 .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Slavetinska, Lenka;
Birkus, Gabriel;
Cihlar, Tomas;
Perlikova, Pavla;
Bourderioux, Aurelie;
Bahador, Gina, Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′- fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides. Bioorganic and Medicinal Chemistry 2012, 20(17), 5202 - 5214, 10.1016/j.bmc.2012.07.003 .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Dzubak, Petr;
Hajduch, Marian;
Snasel, Jan;
Pichova, Iva;
Perlikova, Pavla;
Konecny, Petr, 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents. MedChemComm 2013, 4(11), 1497 - 1500, 10.1039/c3md00232b .
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Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Klepetarova, Blanka;
Vrabel, Milan, Synthesis of 2′-deoxyadenosine nucleosides bearing bipyridine-typeligands and their Ru-complexes in position 8 through cross-coupling rea ctions. Organic and Biomolecular Chemistry.
Holy, Antonin;
Votruba, Ivan;
Rosenberg, Ivan;
Sediva, Katarina, PURINE NUCLEOSIDE PHOSPHORYLASE: ISOLATION AND CHARACTERIZATION. Collect. Czech. Chem. Commun. 1990, 55(12), 2987 - 2999.
Holy, Antonin;
Votruba, Ivan;
Clercq, Erik de;
Koenig, Joachim;
Vesely, Jiri;
Cech, Dieter, 5'-O-ALKYL-5-FLUOROURIDINES: SYNTHESIS AND BIOLOGICAL ACTIVITY. Collect. Czech. Chem. Commun. 1987, 52(6), 1589 - 1608.
Holy, Antonin;
Votruba, Ivan;
Rosenberg, Ivan, AFFINITY CHROMATOGRAPHY OF RAT LIVER S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. Collect. Czech. Chem. Commun. 1983, 48(9), 2549 - 2557.
Holy, Antonin;
Votruba, Ivan;
Vesely, Jiri;
Merta, Ales, S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE FROM MOUSE LEUKEMIC CELLS: ISOLATION AND PROPERTIES. Collect. Czech. Chem. Commun. 1983, 48(9), 2701 - 2708.
Holy, Antonin;
Votruba, Ivan;
Rosenberg, Ivan;
Nishizawa, Masahiko, THE EFFECT OF PHOSPHONYLMETHYL ANALOGS OF RIBONUCLEOSIDE 5'-DIPHOSPHATES ON (E. coli) POLYNUCLEOTIDE PHOSPHORYLASE CATALYZED REACTIONS. Collect. Czech. Chem. Commun. 1987, 52(12), 3042 - 3057.
Holy, Antonin;
Votruba, Ivan;
Sebestova, Ladislava, S-ADENOSINE-L-HOMOCYSTEINE HYDROLASE FROM Nicotiana tabacum L.: ISOLATION AND PROPERTIES. Collect. Czech. Chem. Commun. 1984, 49(6), 1543 - 1551.
Holy, Antonin;
Votruba, Ivan;
Merta, Ales;
Kohoutova, Jitka, 9-(AMINOALKYL)-8-HYDROXYADENINES: PREPARATION, MECHANISM OF FORMATION AND USE IN AFFINITY CHROMATOGRAPHY OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. Collect. Czech. Chem. Commun. 1986, 51(2), 459 - 477.
Holy, Antonin;
Votruba, Ivan, INHIBITION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE BY THE ALIPHATIC NUCLEOSIDE ANALOGUE - 9-(S)-(2,3-DIHYDROXYPROPYL)ADENINE. Collect. Czech. Chem. Commun. 1980, 45(11), 3039 - 3044.
Holy, Antonin;
et al.;
Votruba, Ivan;
Ewing, David F.;
Humble, Robert W.;
Mackenzie, Grahame, Synthesis of 4- and 5-amino-1-(2-deoxy-D-erythro-pentofuranosyl)imidazole nucleosides by chemical and biotransformation methods. Carbohydr. Res. 1991, 216(1), 109 - 118, 10.1016/0008-6215(92)84154-K .
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Holy, Antonin;
Votruba, Ivan;
Cihlar, Tomas;
Rosenberg, Ivan;
Horska, Kvetoslava;
Liboska, Radek, METABOLISM OF 1-(S)-(3-HYDROXY-2-PHOSPHONOMETHOXYPROPYL)CYTOSINE (HPMPC) IN HUMAN EMBRYONIC LUNG CELLS. Collect. Czech. Chem. Commun. 1992, 57(3), 661 - 672, 10.1135/cccc19920661 .
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Holy, Antonin;
Dvorakova, Hana;
Votruba, Ivan;
Masojidkova, Milena, SYNTHESIS AND BIOLOGICAL EFFECTS OF ACYCLIC ANALOGS OF DEAZAPURINE NUCLEOSIDES. Collect. Czech. Chem. Commun. 1993, 58(3), 629 - 648, 10.1135/cccc19930629 .
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Holy, Antonin;
et al.;
Dvorakova, Hana;
Votruba, Ivan;
Hockova, Dana;
Guenter, Jaroslav, SYNTHESIS OF 2-DEOXY-β-D-RIBONUCLEOSIDES AND2,3-DIDEOXY.β-D-PENTOFURANOSIDES ON IMMOBILIZED BACTERIAL CELLS. Collect. Czech. Chem. Commun. 1994, 59(10), 2303 - 2330, 10.1135/cccc19942303 .
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Holy, Antonin;
Votruba, Ivan;
Birkus, Gabriel;
Kramata, Pavel;
Cerny, Jaroslav;
Otova, Berta, DNA-POLYMERASES α, δ AND ε FROM T-CELL SPONTANEOUS LYMPHOBLASTIC LEUKEMIA OF SPRAGUE-DAWLEY INBRED RAT: ISOLATION AND CHARACTERIZATION. Collect. Czech. Chem. Commun. 1995, 60(9), 1555 - 1572, 10.1135/cccc19951555 .
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Holy, Antonin;
Votruba, Ivan;
Zidek, Zdenek, Inhibition of Murine Lymphocyte Proliferation by N-Substituted Acyclic Purine Nucleoside Phosphonates. Collect. Czech. Chem. Commun. 1996, 61, S182 - S187.
Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Birkus, Gabriel;
Kramata, Pavel, Structural Features of Acyclic Nucleotide Analogs Conferring Inhibitory Effects on Cellular Replicative DNA Polymerases. Collect. Czech. Chem. Commun. 1996, 61, S188 - S191.
Holy, Antonin;
Votruba, Ivan;
Cihlar, Tomas;
Olsanska, Lenka, Transport of adefovir (PMEA) in human T-lymphoblastoid cells. Collect. Czech. Chem. Commun. 1997, 62(5), 821 - 828.
Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Birkus, Gabriel;
Kramata, Pavel;
Otova, Berta, Nonproteolyzed form of DNA-polymerase ε from T-cell spontaneous lymphoma of Sprague-Dawley inbred rat: Isolation and characterization. Collect. Czech. Chem. Commun. 1998, 63(5), 723 - 731.
Holy, Antonin;
Votruba, Ivan;
Kramata, Pavel;
Otova, Berta, Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases α, δ, and ε. Molecular Pharmacology 1996, 49(6), 1005 - 1011.
Holy, Antonin;
Votruba, Ivan;
Horska, Kvetoslava;
Krejcova, Romana, Isoenzymes of GMP kinase from L1210 cells: Isolation and characterization. Collect. Czech. Chem. Commun. 1999, 64(3), 559 - 570.
Krecmerova, Marcela;
Holy, Antonin;
Votruba, Ivan;
Hrebabecky, Hubert, Inhibitory potency of 5-benzyluracil, 5-phenylcytosine and 5- phenylpyrimidin-2-one nucleosides against uridine phosphorylase from mouse leukemic L1210 cells. Nucleosides and Nucleotides 1999, 18(11-12), 2551 - 2564.
Holy, Antonin;
Votruba, Ivan;
Horska, Kvetoslava;
Krejcova, Romana, Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells. Collect. Czech. Chem. Commun. 2000, 65(10), 1653 - 1668.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Otmar, Miroslav, An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives. Collect. Czech. Chem. Commun. 2001, 66(3), 500 - 506, 10.1135/cccc20010500 .
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Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Tloustova, Eva, Synthesis and cytostatic activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N-substituted adenines, 2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 2001, 66(10), 1545 - 1592.
Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Birkus, Gabriel, Interactions of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)-propyl]cytosine (cidofovir) diphosphate with DNA polymerases α, δ and ε*. Collect. Czech. Chem. Commun. 2001, 66(11), 1698 - 1706.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve, 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. Journal of Medicinal Chemistry 2002, 45(9), 1918 - 1929, 10.1021/jm011095y .
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Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Capek, Petr;
Otmar, Miroslav, A facile synthesis of 9-deaza analogue of olomoucine. Collect. Czech. Chem. Commun. 2003, 68(4), 779 - 791, 10.1135/cccc20030779 .
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Holy, Antonin;
Votruba, Ivan;
Birkus, Gabriel;
Kramata, Pavel;
Otova, Berta;
Hajek, Miroslav, Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases α, δ, and ε*. Antimicrobial Agents and Chemotherapy 2002, 46(5), 1610 - 1613, 10.1128/AAC.46.5.1610-1613.2002 .
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Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Hockova, Dana, An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6- iodopyrimidine and 2-amino-4,6-dichloropyrimidine. Tetrahedron 2004, 60(23), 4983 - 4987, 10.1016/j.tet.2004.04.035 .
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Holy, Antonin;
Votruba, Ivan;
Tloust'Ova, Eva;
Otova, Berta;
Pomeisl, Karel, Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines. Biochemical Pharmacology 2005, 69(10), 1517 - 1521, 10.1016/j.bcp.2005.03.003 .
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Holy, Antonin;
Votruba, Ivan;
Tloust'Ova, Eva;
Hajek, Miroslav;
Matulova, Nadezda, Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates. Biochemical Pharmacology 2005, 70(6), 894 - 900, 10.1016/j.bcp.2005.06.007 .
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Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Tloust'Ova, Eva;
Hrebabecky, Hubert;
Horska, Kveta;
Nencka, Radim, Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorganic and Medicinal Chemistry Letters 2006, 16(5), 1335 - 1337, 10.1016/j.bmcl.2005.11.050 .
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Holy, Antonin;
Votruba, Ivan;
Schinkmanova, Marketa, N-Methyl-AMP aminohydrolase activates N-substituted purine acyclic nucleoside phosphonates. Biochemical Pharmacology 2006, 71(9), 1370 - 1376, 10.1016/j.bcp.2006.01.013 .
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Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Otmar, Miroslav, Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9- deazapurine and related compounds. Bioorganic and Medicinal Chemistry 2004, 12(12), 3187 - 3195, 10.1016/j.bmc.2004.04.003 .
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Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Simple transformation of thymine 1-[3-hydroxy-2-(phosphonomethoxy)propyl] derivatives to their 1-[3-fluoro-2-(phosphonomethoxy)propyl] counterparts. Collect. Czech. Chem. Commun. 2005, 70(9), 1465 - 1481, 10.1135/cccc2 .
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Holy, Antonin;
Votruba, Ivan;
Horska, Kvetoslava, Interaction of phosphates of the acyclic nucleoside phosphonates with nucleoside diphosphate kinase from yeast and bovine liver. Collect. Czech. Chem. Commun. 2006, 71(1), 35 - 43, 10.1135/cccc20060035 .
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Holy, Antonin;
Votruba, Ivan;
Krejcova, Romana;
Horska, Kvtoslava, Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes. Biochemical Pharmacology 2000, 60(12), 1907 - 1913, 10.1016/S0006-2952(00)00512-8 .
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Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Syntheses of base and side-chain modified pyrimidine 1-[2- (phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Collect. Czech. Chem. Commun. 2006, 71(4), 595 - 624, 10.1135/cccc20060595 .
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Holy, Antonin;
Votruba, Ivan;
Birkus, Gabriel;
Otova, Berta, 9-[2-(phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases α, δ, ε, and ε*. Biochemical Pharmacology 1999, 58(3), 487 - 492, 10.1016/S0006-2952(99)00118-5 .
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Krecmerova, Marcela;
Holy, Antonin;
Votruba, Ivan;
Tloust'Ova, Eva;
Hajek, Miroslav, Alpha anomer of 5-aza-2′-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells. Biochemical Pharmacology 2008, 75(4), 965 - 972, 10.1016/j.bcp.2007.10.018 .
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Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Nucleosides, Nucleotides and Nucleic Acids 2007, 26(8-9), 1025 - 1028, 10.1080/15257770701508679 .
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Holy, Antonin;
Jansa, Petr;
Votruba, Ivan;
Masojidkova, Milena;
Tloust'Ova, Eva;
Hrebabecky, Hubert;
Horska, Kveta;
Nencka, Radim, Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. Journal of Medicinal Chemistry 2007, 50(24), 6016 - 6023, 10.1021/jm070644i .
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Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Syntheses of N-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase. Bioorganic and Medicinal Chemistry Letters 2008, 18(4), 1364 - 1367, 10.1016/j.bmcl.2008.01.006 .
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Holy, Antonin;
Votruba, Ivan;
Cihlar, Tomas;
Schinkmanova, Marketa;
Shibata, Riri;
Han, Bin;
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Patents
Hocek, Michal;
Votruba, Ivan;
HOLandYacute, NOVEL 6-PHENYLPURINE 9-'beta'-D-RIBONUCLEOSIDES WITH ANTINEOPLASTIC ACTIVITY, THEIR USE FOR PREPARING PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH COMPOUNDS, WO2000/75158, 2000.
Holy, Antonin;
Votruba, Ivan;
Tloustova, Eva;
Hajek, Miroslav;
Matulova, Nadezda, USE OF COMPOUNDS TO ENHANCE PROCESSIVITY OF TELOMERASE, WO2006/114064, 2006.