Andrei, Graciela
Articles
Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik, Synthesis and antiviral activity of acyclic nucleotide analogues derived from 6-(aminomethyl)purines and purine-6-carboxamidines. Collect. Czech. Chem. Commun. 1996, 61(10), 1525 - 1537, 10.1135/cccc19961525 
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Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik, Synthesis of 2'-aminomethyl derivatives of N-(2- (phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents. Journal of Medicinal Chemistry 1996, 39(17), 3263 - 3268, 10.1021/jm9601314 .
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Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Guenter, Jaroslav, Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. Journal of Medicinal Chemistry 1999, 42(12), 2064 - 2086, 10.1021/jm9811256 .
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Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve, 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. Journal of Medicinal Chemistry 2002, 45(9), 1918 - 1929, 10.1021/jm011095y .
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Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana, 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy) ethoxy]pyrimidines-Acyclic Nucleoside Phosphonate Analogues with Antiviral Activity. Journal of Medicinal Chemistry 2003, 46(23), 5064 - 5073.
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana, Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2- (phosphonomethoxy)ethoxy]pyrimidine and related compounds. Bioorganic and Medicinal Chemistry 2004, 12(12), 3197 - 3202, 10.1016/j.bmc.2004.04.002 .
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Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Pohl, Radek;
Clercq, Erik de;
Horejsi, Katerina, Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity. Bioorganic and Medicinal Chemistry 2006, 14(23), 8057 - 8065, 10.1016/j.bmc.2006.07.036 .
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Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve;
Piskala, Alois;
Neyts, Johan, Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2- (phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry 2007, 50(5), 1069 - 1077, 10.1021/jm061281+ .
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Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Lebeau, Ilya, Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Antimicrobial Agents and Chemotherapy 2007, 51(6), 2268 - 2273, 10.1128/AAC.01422-06 .
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Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Duraffour, Sophie;
Van Den Oord, Joost;
De Vos, Rita;
Crance, Jean-Marc;
Garin, Daniel, Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. Antimicrobial Agents and Chemotherapy 2007, 51(12), 4410 - 4419, 10.1128/AAC.00838-07 .
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Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Pohl, Radek;
Naesens, Lieve;
Neyts, Johan, Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5- azacytosine: Synthesis and antiviral activity. Journal of Medicinal Chemistry 2007, 50(23), 5765 - 5772, 10.1021/jm0707166 .
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Krecmerova, Marcela;
Holy, Antonin;
Votruba, Ivan;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Naesens, Lieve;
Neyts, Johan, Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. Biochemical Pharmacology 2008, 76(8), 997 - 1005, 10.1016/j.bcp.2008.08.009 .
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Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Pohl, Radek;
Clercq, Erik de;
Janeba, Zlatko, Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base. Canadian Journal of Chemistry 2010, 88(7), 628 - 638, 10.1139/V10-054 .
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Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Pohl, Radek;
Cihlar, Tomas;
Naesens, Lieve;
Pomeisl, Karel;
Neyts, Johan;
Tichy, Tomas;
Brehova, Petra;
Laflamme, Genevieve;
Hui, Hon, Synthesis of ester prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl] -2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. Journal of Medicinal Chemistry 2010, 53(19), 6825 - 6837, 10.1021/jm901828c .
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Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Tichy, Tomas, New prodrugs of Adefovir and Cidofovir. Bioorganic and Medicinal Chemistry 2011, 19(11), 3527 - 3539, 10.1016/j.bmc.2011.04.016 .
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Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Hockova, Dana, Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity. Bioorganic and Medicinal Chemistry 2011, 19(15), 4445 - 4453, 10.1016/j.bmc.2011.06.045 .
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Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Gammon, Don B.;
Fiten, Pierre;
Opdenakker, Ghislain;
Evans, David H., Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs. Journal of Virology 2008, 82(24), 12520 - 12534, 10.1128/JVI.01528-08 .
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Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Schols, Dominique;
Balestra, Emanuela;
Huskens, Dana;
Vanpouille, Christophe;
Introini, Andrea;
Zicari, Sonia;
Liekens, Sandra;
Perno, Carlo-Federico;
Margolis, Leonid, A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity. PLoS Pathogens 2013, 9(7), 10.1371/journal.ppat.1003456 .
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Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Janeba, Zlatko;
Robins, Morris J., Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides. Journal of Medicinal Chemistry 2005, 48(14), 4690 - 4696, 10.1021/jm050291s .
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Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Janeba, Zlatko;
Robins, Morris J., Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl) uracil derivatives. Canadian Journal of Chemistry 2006, 84(4), 580 - 586, 10.1139/V06-041 .
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Krecmerova, Marcela;
Dracinsky, Martin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Tichy, Tomas, Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety. Eur. J. Med. Chem. 2012, 55, 307 - 314,8, 10.1016/j.ejmech.2012.07.027 .
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Krecmerova, Marcela;
Andrei, Graciela;
Snoeck, Robert;
Duraffour, Sophie;
Crance, Jean-Marc;
Garin, Daniel;
Topalis, Dimitri, Mutations conferring resistance to viral DNA polymerase inhibitors in camelpox virus give different drug-susceptibility profiles in vaccinia virus. Journal of Virology 2012, 86(13), 7310 - 7325, 10.1128/JVI.00355-12 .
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Krecmerova, Marcela;
Andrei, Graciela;
Snoeck, Robert;
Naesens, Lieve;
Duraffour, Sophie;
Coen, Natacha;
Oord, Joost Van den, Evaluation of novel acyclic nucleoside phosphonates against human and animal gammaherpesviruses revealed an altered metabolism of cyclic prodrugs upon epstein-barr virus reactivation in P3HR-1 cells. Journal of Virology 2013, 87(22), 12422 - 12432, 10.1128/JVI.02231-13 .
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Krecmerova, Marcela;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Pohl, Radek, N-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: Chemistry and antiviral activity. Bioorganic and Medicinal Chemistry 2014, 22(10), 2896 - 2906, 10.1016/j.bmc.2014.03.031 .
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