Balzarini, Jan
Articles
Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik, Synthesis and antiviral activity of acyclic nucleotide analogues derived from 6-(aminomethyl)purines and purine-6-carboxamidines. Collect. Czech. Chem. Commun. 1996, 61(10), 1525 - 1537, 10.1135/cccc19961525 
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Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik, Synthesis of 2'-aminomethyl derivatives of N-(2- (phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents. Journal of Medicinal Chemistry 1996, 39(17), 3263 - 3268, 10.1021/jm9601314 .
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Budesinsky, Milos;
Holy, Antonin;
Jindrich, Jindrich;
Dvorakova, Hana;
Masojidkova, Milena;
Balzarini, Jan;
De Clercq, Erik;
Andrei, Graciella, Acyclic nucleotide analogs derived from 8-azapurines: Synthesis and antiviral activity. Journal of Medicinal Chemistry 1996, 39(20), 4073 - 4088, 10.1021/jm960314q .
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Holy, Antonin;
Balzarini, Jan;
Hrebabecky, Hubert, Preparation of chloro and sulfanyl derivatives of 1-(2-deoxy-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)uracil. Collect. Czech. Chem. Commun. 1997, 62(7), 1114 - 1127.
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Guenter, Jaroslav, Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. Journal of Medicinal Chemistry 1999, 42(12), 2064 - 2086, 10.1021/jm9811256 .
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Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve, 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. Journal of Medicinal Chemistry 2002, 45(9), 1918 - 1929, 10.1021/jm011095y .
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Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana, 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy) ethoxy]pyrimidines-Acyclic Nucleoside Phosphonate Analogues with Antiviral Activity. Journal of Medicinal Chemistry 2003, 46(23), 5064 - 5073.
Holy, Antonin;
Balzarini, Jan;
De Clercq, Erik;
Naesens;
Lenaerts;
Andrei;
Snoeck;
Van Beers, Antiadenovirus activities of several classes of nucleoside and nucleotide analogues. Antimicrobial Agents and Chemotherapy 2005, 49(3), 1010 - 1016, 10.1128/AAC.49.3.1010-1016.2005 .
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Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana, Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2- (phosphonomethoxy)ethoxy]pyrimidine and related compounds. Bioorganic and Medicinal Chemistry 2004, 12(12), 3197 - 3202, 10.1016/j.bmc.2004.04.002 .
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Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve;
Piskala, Alois;
Neyts, Johan, Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2- (phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry 2007, 50(5), 1069 - 1077, 10.1021/jm061281+ .
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Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Pohl, Radek;
Naesens, Lieve;
Neyts, Johan, Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5- azacytosine: Synthesis and antiviral activity. Journal of Medicinal Chemistry 2007, 50(23), 5765 - 5772, 10.1021/jm0707166 .
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Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Pohl, Radek;
Clercq, Erik de;
Janeba, Zlatko, Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base. Canadian Journal of Chemistry 2010, 88(7), 628 - 638, 10.1139/V10-054 .
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Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Pohl, Radek;
Cihlar, Tomas;
Naesens, Lieve;
Pomeisl, Karel;
Neyts, Johan;
Tichy, Tomas;
Brehova, Petra;
Laflamme, Genevieve;
Hui, Hon, Synthesis of ester prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl] -2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. Journal of Medicinal Chemistry 2010, 53(19), 6825 - 6837, 10.1021/jm901828c .
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Holy, Antonin;
Votruba, Ivan;
Balzarini, Jan;
Herman, Brian D.;
Sluis-Cremer, Nicolas, The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization. Journal of Biological Chemistry 2010, 285(16), 12101 - 12108, 10.1074/jbc.M109.096529 .
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Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Votruba, Ivan;
Balzarini, Jan;
Klepetarova, Blanka;
Clercq, Erik de;
Janeba, Zlatko;
Baszczynski, Ondrej, Synthesis and antiviral activity of N-[3-fluoro-2- (phosphonomethoxy)propyl] analogues derived from N-substituted adenines and 2,6-diaminopurines. Bioorganic and Medicinal Chemistry 2011, 19(7), 2114 - 2124, 10.1016/j.bmc.2011.02.050 .
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Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Tichy, Tomas, New prodrugs of Adefovir and Cidofovir. Bioorganic and Medicinal Chemistry 2011, 19(11), 3527 - 3539, 10.1016/j.bmc.2011.04.016 .
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Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Hockova, Dana, Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity. Bioorganic and Medicinal Chemistry 2011, 19(15), 4445 - 4453, 10.1016/j.bmc.2011.06.045 .
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Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Balzarini, Jan;
Klepetarova, Blanka;
Janeba, Zlatko;
Baszczynski, Ondrej;
Hradil, Ondrej, An efficient microwave-assisted synthesis and biological properties of polysubstituted pyrimidinyl- and 1,3,5-triazinylphosphonic acids. Tetrahedron 2012, 68(3), 865 - 871, 10.1016/j.tet.2011.11.040 .
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Holy, Antonin;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana;
Schols, Dominique;
Van Laethem, Kristel;
Masojidkova, Milina, Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines. Journal of Antimicrobial Chemotherapy 2007, 59(1), 80 - 86, 10.1093/jac/dkl454 .
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Holy, Antonin;
Jindrich, Jindrich;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve;
Hartmann, Katrin;
Kuffer, Manuela;
Goldberg, Michel;
Erfle, Volker;
Goebel, Frank-Detlef;
Bischofberger, Norbert;
Kraft, Wilfried, Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1998, 17(2), 120 - 128.
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Schols, Dominique;
Balestra, Emanuela;
Huskens, Dana;
Vanpouille, Christophe;
Introini, Andrea;
Zicari, Sonia;
Liekens, Sandra;
Perno, Carlo-Federico;
Margolis, Leonid, A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity. PLoS Pathogens 2013, 9(7), 10.1371/journal.ppat.1003456 .
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Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Janeba, Zlatko;
Robins, Morris J., Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides. Journal of Medicinal Chemistry 2005, 48(14), 4690 - 4696, 10.1021/jm050291s .
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Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Janeba, Zlatko;
Robins, Morris J., Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl) uracil derivatives. Canadian Journal of Chemistry 2006, 84(4), 580 - 586, 10.1139/V06-041 .
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Krecmerova, Marcela;
Dracinsky, Martin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Tichy, Tomas, Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety. Eur. J. Med. Chem. 2012, 55, 307 - 314,8, 10.1016/j.ejmech.2012.07.027 .
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Krecmerova, Marcela;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Pohl, Radek, N-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: Chemistry and antiviral activity. Bioorganic and Medicinal Chemistry 2014, 22(10), 2896 - 2906, 10.1016/j.bmc.2014.03.031 .
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Balzarini, Jan;
Rosenberg, Ivan;
Naesens, Lieve;
Slachmuylders, Jan;
Niphuis, Henk;
Holy, Anthony;
Schellekens, Huub;
Clercq, Erik, 9-(2-phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys. AIDS 1991, 5(1), 21 - 28.
Patents
Holy, Antonin;
Jindrich, Jindrich;
Balzarini, Jan;
De Clercq, Erik, Antiretroviral bases, EP454427, 1991.