Hrebabecky, Hubert
Articles
Holy, Antonin;
Hrebabecky, Hubert;
Clercq, Erik de, SYNTHESIS OF 3'-AZIDO-2',3'-DIDEOXY-6-METHYLURIDINE, 2',3'-DIDEOXY-6-METHYLURIDINE AND 2',3'-DIDEOXY-2',3'-DIDEHYDRO-6-METHYLURIDINE. Collect. Czech. Chem. Commun. 1990, 55(7), 1801 - 1811.
Krecmerova, Marcela;
Holy, Antonin;
Hrebabecky, Hubert, SYNTHESIS OF 5'-O-PHOSPHONOMETHYL DERIVATIVES OF PYRIMIDINE 2'-DEOXYNUCLEOSIDES. Collect. Czech. Chem. Commun. 1990, 55(10), 2521 - 2536.
Holy, Antonin;
Hrebabecky, Hubert, SYNTHESIS OF 1-(3-AZIDO-2,3-DIDEOXY-4-C-HYDROXYMETHYL-α-L-threo-PENTOFURANOSYL)THYMINE, 1-(2,3-DIDEOXY-4-C-HYDROXYMETHYL-α-L-glycero-PENTOFURANOSYL)THYMINE AND 1-(2,3-DIDEOXY-4-C-HYDROXYMETHYL-α-L-glycero-PENT-2-ENOFURANOSYL)THYMINE. Collect. Czech. Chem. Commun. 1993, 58(2), 409 - 420, 10.1135/cccc19930409 
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Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, PREPARATION OF PURINE 2'-DEOXY-5'-O-PHOSPHONOMETHYLNUCLEOSIDES AND 2'-DEOXY-3'-O-PHOSPHONOMETHYLNUCLEOSIDES. Collect. Czech. Chem. Commun. 1993, 58(2), 421 - 434, 10.1135/cccc19930421 .
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Holy, Antonin;
Hrebabecky, Hubert, SYNTHESIS OF 1-(2,3-DIDEOXY-4-C-METHYL-β-D-glycero-PENT-2-ENOFURANOSYL)THYMINE, 1-(2,3-DIDEOXY-4-C-METHYL-β-D-glycero-PENTOFURANOSYL)THYMINE AND 1-(4-C-AZIDOMETHYL-2-DEOXY-β-D-threoPENTOFURANOSYL)THYMINE. Collect. Czech. Chem. Commun. 1993, 58(7), 1668 - 1674, 10.1135/cccc19931668 .
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Holy, Antonin;
Hrebabecky, Hubert, SYNTHESIS OF 1-(3-AZIDO-2,3-DIDEOXY-β-D-ribo-HEXOFURANOSYL)-, 1-(2,3-DIDEOXY-β-D-erythro-HEXOFURANOSYL)- AND 1-(2,3-DIDEOXY-β-D-erythro-HEX-2-ENOFURANOSYL)PYRIMIDINE NUCLEOSIDES. Collect. Czech. Chem. Commun. 1994, 59(2), 412 - 420, 10.1135/cccc19940412 .
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Holy, Antonin;
Hrebabecky, Hubert;
Dockal, Jan, SYNTHESIS OF DEOXY, DIDEOXY AND DIDEHYDRODIDEOXY ANALOGS OF 9-(β-D-HEXOFURANOSYL)ADENINE. Collect. Czech. Chem. Commun. 1994, 59(6), 1408 - 1419, 10.1135/cccc19941408 .
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Holy, Antonin;
Hrebabecky, Hubert, SYNTHESIS OF DEOXY, DIDEOXY AND DIDEHHYDRODIDEOXY ANALOGS OF 9-(4-C-HYDROXYMETHYL-α-L-PENTOFURANOSYL)ADENINE. Collect. Czech. Chem. Commun. 1994, 59(7), 1654 - 1664, 10.1135/cccc19941654 .
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Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of 5-phenyl-2(1H)-pyrimidinone nucleosides. Collect. Czech. Chem. Commun. 1996, 61(3), 458 - 477, 10.1135/cccc19960458 .
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Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, 2′,3′-dideoxy- and 3′-azido-2′,3′-dideoxynucleosides of 5-phenyl-2(1H)-pyrimidinone. Preparation of 2′,3′-dideoxypentofuranoses. Collect. Czech. Chem. Commun. 1996, 61(3), 478 - 488, 10.1135/cccc19960478 .
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Krecmerova, Marcela;
Holy, Antonin;
Hrebabecky, Hubert, Preparation of 5-benzyluracil and 5-benzylcytosine nucleosides as potential inhibitors of uridine phosphorylase. Collect. Czech. Chem. Commun. 1996, 61(4), 627 - 644, 10.1135/cccc19960627 .
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Krecmerova, Marcela;
Holy, Antonin;
Hrebabecky, Hubert, Synthesis of 5-phenylcytosine nucleoside derivatives. Collect. Czech. Chem. Commun. 1996, 61(4), 645 - 655, 10.1135/cccc19960645 .
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Holy, Antonin;
Hrebabecky, Hubert;
Chu, Lan Dinh, A New Synthesis of 2,2'-Anhydro-5-alkyl/alryl-3-glycosyluracils. Collect. Czech. Chem. Commun. 1996, 61, S129 - S131.
Holy, Antonin;
Balzarini, Jan;
Hrebabecky, Hubert, Preparation of chloro and sulfanyl derivatives of 1-(2-deoxy-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)uracil. Collect. Czech. Chem. Commun. 1997, 62(7), 1114 - 1127.
Holy, Antonin;
Hrebabecky, Hubert, Preparation of thymidine-4′-C-carboxylic acid and its derivatives. Collect. Czech. Chem. Commun. 1997, 62(7), 1128 - 1135.
Budesinsky, Milos;
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert;
Havlas, Zdenek, 1-(3,5-O-alkylidene-2-deoxy-4-C-hydroxymethyl-α-L-threo- pentofuranosyl)uracils. Collect. Czech. Chem. Commun. 1997, 62(6), 957 - 970.
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of carba analogues of deoxy-4-C-(hydroxymethyl)-pentofuranoses, intermediates in the synthesis of carbocyclic nucleosides. Collect. Czech. Chem. Commun. 1998, 63(12), 2044 - 2064.
Holy, Antonin;
Hrebabecky, Hubert, Synthesis of carba analogues of 2′-deoxy-4′-C-(hydroxymethyl)nucleosides. Collect. Czech. Chem. Commun. 1999, 64(9), 1485 - 1496.
Krecmerova, Marcela;
Holy, Antonin;
Votruba, Ivan;
Hrebabecky, Hubert, Inhibitory potency of 5-benzyluracil, 5-phenylcytosine and 5- phenylpyrimidin-2-one nucleosides against uridine phosphorylase from mouse leukemic L1210 cells. Nucleosides and Nucleotides 1999, 18(11-12), 2551 - 2564.
Holy, Antonin;
Hrebabecky, Hubert, Synthesis of carbocyclic 4′-C-hydroxymethyl analogues of azidodeoxythymidine, deoxythymidine, deoxydidehydrothymidine and thymidine carba analogue with fused oxetane ring. Collect. Czech. Chem. Commun. 2000, 65(3), 395 - 406.
Holy, Antonin;
Hrebabecky, Hubert, Synthesis of carba analogues of deoxy-4-C-(hydroxymethyl)-hexopyranoses, intermediates in the synthesis of carbocyclic nucleosides. Collect. Czech. Chem. Commun. 2001, 66(5), 785 - 798, 10.1135/cccc20010785 .
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Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of racemic 2-hydroxy-4- and 2-hydroxy-5-(hydroxymethyl)cyclohexane nucleoside analogues. Collect. Czech. Chem. Commun. 2002, 67(11), 1681 - 1699, 10.1135/cccc20021681 .
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Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert;
Sala, Michal, Synthesis of racemic 2-hydroxy-4- and 2-hydroxy-5-(hydroxymethyl) cyclohexane pyrimidine C-Nucleoside analogues. Collect. Czech. Chem. Commun. 2004, 69(4), 918 - 932, 10.1135/cccc20040918 .
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Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of purine nucleoside analogues derived from carbocyclic 5-C-(hydroxymethyl)hexopyranoses. Collect. Czech. Chem. Commun. 2004, 69(2), 435 - 452.
Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of racemic 9-(6- and 2,6-substituted 9H-purin-9-yl)-5- oxatricyclo[4.2.1.0]nonane-3-methanols, novel conformationally locked carbocyclic nucleosides. Collect. Czech. Chem. Commun. 2005, 70(1), 103 - 123, 10.1135/cccc20050103 .
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Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Tloust'Ova, Eva;
Hrebabecky, Hubert;
Horska, Kveta;
Nencka, Radim, Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorganic and Medicinal Chemistry Letters 2006, 16(5), 1335 - 1337, 10.1016/j.bmcl.2005.11.050 .
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Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of novel conformationally locked carbocyclic nucleosides derived from 5,5- and 6,6-bis(hydroxymethyl)bicyclo[2.2.1]heptan-2-ol. Collect. Czech. Chem. Commun. 2005, 70(4), 519 - 538, 10.1135/cccc20050519 .
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Holy, Antonin;
Masojidkova, Milena;
Hrebabecky, Hubert;
Sala, Michal, Synthesis of novel racemic conformationally locked carbocyclic nucleosides derived from 7-substituted bicyclo[2.2.1]hept-5-ene-2,2-dimethanols. Collect. Czech. Chem. Commun. 2006, 71(5), 635 - 649, 10.1135/cccc20060635 .
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Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Hrebabecky, Hubert, Synthesis of novel conformationally locked carbocyclic nucleosides derived from 3-(hydroxymethyl)bicyclo[2.2.1]heptane-2,5-diol. Collect. Czech. Chem. Commun. 2006, 71(6), 871 - 888, 10.1135/cccc20060871 .
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Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert, Synthesis of novel carbocyclic nucleosides and pro-tides derived from 4-oxatricyclo[4.2.1.0]nonane-9-methanol. Collect. Czech. Chem. Commun. 2007, 72(10), 1331 - 1349, 10.1135/cccc20071331 .
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Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert;
Dejmek, Milan, Synthesis of novel carbocyclic nucleoside analogues derived from 2-(hydroxymethyl)bicyclo[2.2.1]heptane. Collect. Czech. Chem. Commun. 2007, 72(11), 1523 - 1544, 10.1135/cccc20071523 .
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Holy, Antonin;
Jansa, Petr;
Votruba, Ivan;
Masojidkova, Milena;
Tloust'Ova, Eva;
Hrebabecky, Hubert;
Horska, Kveta;
Nencka, Radim, Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. Journal of Medicinal Chemistry 2007, 50(24), 6016 - 6023, 10.1021/jm070644i .
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Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert, Synthesis of novel carbocyclic nucleoside analogues containing bicyclo[2.2.1]hept-2-ene-2-methanol. Collect. Czech. Chem. Commun. 2008, 73(1), 44 - 58, 10.1135/cccc20080044 .
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Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert;
Neyts, Johan;
De Palma, Armando M., Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol. Collect. Czech. Chem. Commun. 2009, 74(3), 487 - 502, 10.1135/cccc2008204 .
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Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert;
Neyts, Johan;
De Palma, Armando M., Synthesis of novel racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.0]nonane- 9-methanol and 4-oxatricyclo[4.3.1.0]decane-10-methanol, compounds with activity against coxsackie viruses. Collect. Czech. Chem. Commun. 2009, 74(3), 469 - 485, 10.1135/cccc2008193 .
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Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Hrebabecky, Hubert;
Sala, Michal;
Neyts, Johan;
De Palma, Armando M., Norbornane as the novel pseudoglycone moiety in nucleosides. Tetrahedron 2009, 65(45), 9291 - 9299, 10.1016/j.tet.2009.09.018 .
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Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert, New carbocyclic nucleoside analogues built on a bicyclo[2.2.2]octane-2,2- dimethanol template. Collect. Czech. Chem. Commun. 2009, 74(9), 1425 - 1441, 10.1135/cccc2009090 .
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Holy, Antonin;
Dracinsky, Martin;
Hrebabecky, Hubert;
Sala, Michal;
Nencka, Radim;
Neyts, Johan;
De Palma, Armando M.;
Leyssen, Pieter, Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors. Bioorganic and Medicinal Chemistry 2010, 18(12), 4374 - 4384, 10.1016/j.bmc.2010.04.081 .
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Holy, Antonin;
Votruba, Ivan;
Otmar, Miroslav;
Rosenberg, Ivan;
Hrebabecky, Hubert;
Merta, Ales;
Bernaerts, Ria, Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues. Antiviral Research 1990, 13(5), 209 - 218, 10.1016/0166-3542(90)90066-G .
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Patents
Holy, Antonin;
Hrebabecky, Hubert;
Sala, Michal;
Neyts, Johan;
DE PALMA, Armando, NEW ANTIVIRAL COMPOUNDS, WO2008/131502, 2008.
Holy, Antonin;
Hrebabecky, Hubert;
Sala, Michal;
Neyts, Johan;
DE PALMA, Armando, NEW ANTI-VIRAL NUCLEOSIDE ANALOGS, WO2008/131501, 2008.