Zidek, Zdenek
Articles
Holy, Antonin;
Votruba, Ivan;
Zidek, Zdenek, Inhibition of Murine Lymphocyte Proliferation by N-Substituted Acyclic Purine Nucleoside Phosphonates. Collect. Czech. Chem. Commun. 1996, 61, S182 - S187.
Holy, Antonin;
Otova, Berta;
Zidek, Zdenek;
Frankova, Daniela, Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs. Eur. J. Pharmacol. 1995, 286(3), 307 - 310, 10.1016/0014-2999(95)00586-3 
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Holy, Antonin;
Zidek, Zdenek;
Bortos, Sanaa;
William, Samia;
Hammam, Olfat, Activity of 9-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]Adenine against Schistosomiasis mansoni in Mice. Antimicrobial Agents and Chemotherapy 2003, 47(12), 3853 - 3858, 10.1128/AAC.47.12.3853-3858.2003 .
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Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva, Involvement of adenosine A receptors in upregulation of nitric oxide by acyclic nucleotide analogues. Eur. J. Pharmacol. 2004, 501(1-3), 79 - 86, 10.1016/j.ejphar.2004.08.031 .
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Holy, Antonin;
Masojidkova, Milena;
Zidek, Zdenek;
Kmonickova, Eva;
Dolakova, Petra, Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives. Bioorganic and Medicinal Chemistry 2005, 13(7), 2349 - 2354, 10.1016/j.bmc.2005.01.054 .
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Holy, Antonin;
Cesnek, Michal;
Masojidkova, Milena;
Zidek, Zdenek, Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6- guanidinopurines and their influence on the NO-production in macrophages. Bioorganic and Medicinal Chemistry 2005, 13(8), 2917 - 2926, 10.1016/j.bmc.2005.02.008 .
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Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Potmesil, Petr, Purine P receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine. Eur. J. Pharmacol. 2006, 530(1-2), 179 - 187, 10.1016/j.ejphar.2005.11.037 .
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Holy, Antonin;
Zidek, Zdenek;
Frankova, Daniela;
Boubelik, Michael;
Draber, Petr, Inhibition of murine macrophage nitric oxide synthase expression by a pivoxil prodrug of antiviral acyclic nucleotide analogue 9-(2-phosphonomethoxyethyl)adenine. Biochemical Pharmacology 1997, 54(8), 855 - 861, 10.1016/S0006-2952(97)00228-1 .
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Holy, Antonin;
Zidek, Zdenek;
Potmesil, Petr;
Kmoniekova, Eva, Immunobiological activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N-substituted adenines, and 2,6-diaminopurines. Eur. J. Pharmacol. 2003, 475(1-3), 149 - 159, 10.1016/S0014-2999(03)02110-1 .
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Krecmerova, Marcela;
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Potmesil, Petr, Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N-substituted derivatives. Eur. J. Pharmacol. 2006, 540(1-3), 191 - 199, 10.1016/j.ejphar.2006.04.018 .
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Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva, Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates. Eur. J. Pharmacol. 2007, 574(1), 77 - 84, 10.1016/j.ejphar.2007.07.024 .
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Holy, Antonin;
Cesnek, Michal;
Masojidkova, Milena;
Zidek, Zdenek;
Kmonickova, Eva, Synthesis of guanidino analogues of PMPDAP and their immunobiological activity. Bioorganic and Medicinal Chemistry 2008, 16(2), 965 - 980, 10.1016/j.bmc.2007.10.010 .
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Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Votruba, Ivan;
Mackman, Richard;
Cihlar, Tomas;
Bahador, Gina;
Janeba, Zlatko;
Zidek, Zdenek;
Baszczynski, Ondrej;
Stepan, George, A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities. European Journal of Medicinal Chemistry 2011, 46(9), 3748 - 3754, 10.1016/j.ejmech.2011.05.040 .
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Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Potmesil, Petr;
Anzenbacher, Pavel;
Anzenbacherova, Eva;
Buchar, Evzen, In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes. Journal of Biomedical Science 2006, 13(3), 295 - 301, 10.1007/s11373-005-9067-1 .
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Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva, Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 2005, 149(2), 315 - 319.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Canova, Nikolina Kutinova;
Farghali, Hassan, Modulator of intracellular Ca(2+), thapsigargin, interferes with in vitro secretion of cytokines and nitric oxide.. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 2005, 149(2), 321 - 324.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Potmesil, Petr;
Krizkova, Jana, Acyclic nucleoside phosphonate antivirals activate gene expression of monocyte chemotactic protein 1 and 3. Journal of Biomedical Science 2007, 14(1), 59 - 66, 10.1007/s11373-006-9116-4 .
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Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Farghali, Hassan;
Melkusova, Petra, Nitric oxide production in mouse and rat macrophages: A rapid and efficient assay for screening of drugs immunostimulatory effects in human cells. Nitric Oxide - Biology and Chemistry 2007, 17(3-4), 160 - 169, 10.1016/j.niox.2007.06.006 .
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Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva;
Farghali, Hassan;
Kostecka, Petra, Differential effects of acyclic nucleoside phosphonates on nitric oxide and cytokines in rat hepatocytes and macrophages. International Immunopharmacology 2012, 12(2), 342 - 349, 10.1016/j.intimp.2011.12.005 .
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Holy, Antonin;
Zidek, Zdenek;
Potmesil, Petr, Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes. Toxicology and Applied Pharmacology 2003, 192(3), 246 - 253, 10.1016/S0041-008X(03)00215-1 .
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Holy, Antonin;
Zidek, Zdenek;
Frankova, Daniela, Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). Eur. J. Pharmacol. 1999, 376(1-2), 91 - 100, 10.1016/S0014-2999(99)00343-X .
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Holy, Antonin;
Votruba, Ivan;
Otova, Berta;
Zidek, Zdenek;
Sladka, Milada;
Marinov, Iuri;
Leskova, Veronika, Antitumor activity of novel purine acyclic nucleotide analogs pmea and pmedap. In Vivo 1997, 11(2), 163 - 168.