Naesens, Lieve
Articles
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve, 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. Journal of Medicinal Chemistry 2002, 45(9), 1918 - 1929, 10.1021/jm011095y 
.
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve;
Piskala, Alois;
Neyts, Johan, Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2- (phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry 2007, 50(5), 1069 - 1077, 10.1021/jm061281+ .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Pohl, Radek;
Naesens, Lieve;
Neyts, Johan, Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5- azacytosine: Synthesis and antiviral activity. Journal of Medicinal Chemistry 2007, 50(23), 5765 - 5772, 10.1021/jm0707166 .
.
Krecmerova, Marcela;
Holy, Antonin;
Votruba, Ivan;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Naesens, Lieve;
Neyts, Johan, Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. Biochemical Pharmacology 2008, 76(8), 997 - 1005, 10.1016/j.bcp.2008.08.009 .
.
Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Pohl, Radek;
Cihlar, Tomas;
Naesens, Lieve;
Pomeisl, Karel;
Neyts, Johan;
Tichy, Tomas;
Brehova, Petra;
Laflamme, Genevieve;
Hui, Hon, Synthesis of ester prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl] -2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. Journal of Medicinal Chemistry 2010, 53(19), 6825 - 6837, 10.1021/jm901828c .
.
Krecmerova, Marcela;
Holy, Antonin;
Cesnek, Michal;
Hockova, Dana;
Naesens, Lieve;
Keough, Dianne T.;
De Jersey, John;
Guddat, Luke W.;
Brereton, Ian M.;
Winzor, Donald J., Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy. Molecular and Biochemical Parasitology 2010, 173(2), 165 - 169, 10.1016/j.molbiopara.2010.05.018 .
.
Holy, Antonin;
De Clercq, Erik;
Naesens, Lieve;
Neyts, Johan;
Stittelaar, Koert J.;
Van Amerongen, Geert;
Van Lavieren, Rob F.;
Niesters, Hubert G. M.;
Fries, Edwin;
Maas, Chantal;
Mulder, Paul G. H.;
Van Der Zeijst, Ben A. M.;
Osterhaus, Albert D. M. E., Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. Nature 2006, 439(7077), 745 - 748, 10.1038/nature04295 .
.
Holy, Antonin;
Hockova, Dana;
Naesens, Lieve;
Keough, Dianne T.;
De Jersey, John;
Guddat, Luke W., 6-oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugs. Current Topics in Medicinal Chemistry 2011, 11(16), 2085 - 2102, 10.2174/156802611796575911 .
.
Holy, Antonin;
Jindrich, Jindrich;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve;
Hartmann, Katrin;
Kuffer, Manuela;
Goldberg, Michel;
Erfle, Volker;
Goebel, Frank-Detlef;
Bischofberger, Norbert;
Kraft, Wilfried, Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1998, 17(2), 120 - 128.
Holy, Antonin;
De Clercq, Erik;
Naesens, Lieve;
Kaminsky, Ronald;
Schmid, Cecile;
Grether, Yvonne;
Brun, Reto, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA]: A purine analogue with trypanocidal activity in vitro and in vivo. Tropical Medicine and International Health 1996, 1(2), 255 - 263.
Hockova, Dana;
Slavetinska, Lenka;
Janeba, Zlatko;
Naesens, Lieve;
Vrbkova, Silvie;
Keough, Dianne T.;
De Jersey, John;
Guddat, Luke W.;
Tichy, Tomas;
Spacek, Petr;
Wang, Tzu-Hsuan;
Edstein, Michael D.;
Chavchich, Marina, Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. Journal of Medicinal Chemistry 2013, 56(6), 2513 - 2526, 10.1021/jm301893b .
.
Krecmerova, Marcela;
Andrei, Graciela;
Snoeck, Robert;
Naesens, Lieve;
Duraffour, Sophie;
Coen, Natacha;
Oord, Joost Van den, Evaluation of novel acyclic nucleoside phosphonates against human and animal gammaherpesviruses revealed an altered metabolism of cyclic prodrugs upon epstein-barr virus reactivation in P3HR-1 cells. Journal of Virology 2013, 87(22), 12422 - 12432, 10.1128/JVI.02231-13 .
.
Balzarini, Jan;
Rosenberg, Ivan;
Naesens, Lieve;
Slachmuylders, Jan;
Niphuis, Henk;
Holy, Anthony;
Schellekens, Huub;
Clercq, Erik, 9-(2-phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys. AIDS 1991, 5(1), 21 - 28.