Pomeisl, Karel

Holy, Antonin; Votruba, Ivan; Tloust'Ova, Eva; Otova, Berta; Pomeisl, Karel, Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines. Biochemical Pharmacology 2005, 69(10), 1517 - 1521, 10.1016/j.bcp.2005.03.003 .

Holy, Antonin; Votruba, Ivan; Pohl, Radek; Pomeisl, Karel, Simple transformation of thymine 1-[3-hydroxy-2-(phosphonomethoxy)propyl] derivatives to their 1-[3-fluoro-2-(phosphonomethoxy)propyl] counterparts. Collect. Czech. Chem. Commun. 2005, 70(9), 1465 - 1481, 10.1135/cccc2 .

Holy, Antonin; Votruba, Ivan; Pohl, Radek; Pomeisl, Karel, Syntheses of base and side-chain modified pyrimidine 1-[2- (phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Collect. Czech. Chem. Commun. 2006, 71(4), 595 - 624, 10.1135/cccc20060595 .

Holy, Antonin; Pohl, Radek; Pomeisl, Karel, Pd-catalyzed Suzuki-Miyaura coupling reactions in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase. Tetrahedron Letters 2007, 48(17), 3065 - 3067, 10.1016/j.tetlet.2007.02.107 .

Holy, Antonin; Votruba, Ivan; Pohl, Radek; Pomeisl, Karel, Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Nucleosides, Nucleotides and Nucleic Acids 2007, 26(8-9), 1025 - 1028, 10.1080/15257770701508679 .

Holy, Antonin; Votruba, Ivan; Pohl, Radek; Pomeisl, Karel, Syntheses of N-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase. Bioorganic and Medicinal Chemistry Letters 2008, 18(4), 1364 - 1367, 10.1016/j.bmcl.2008.01.006 .

Holy, Antonin; Pohl, Radek; Horska, Kvetoslava; Pomeisl, Karel, Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase. Tetrahedron 2009, 65(41), 8486 - 8492, 10.1016/j.tet.2009.08.039 .

Krecmerova, Marcela; Holy, Antonin; Dracinsky, Martin; Masojidkova, Milena; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Pohl, Radek; Cihlar, Tomas; Naesens, Lieve; Pomeisl, Karel; Neyts, Johan; Tichy, Tomas; Brehova, Petra; Laflamme, Genevieve; Hui, Hon, Synthesis of ester prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl] -2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. Journal of Medicinal Chemistry 2010, 53(19), 6825 - 6837, 10.1021/jm901828c .

Holy, Antonin; Votruba, Ivan; Pohl, Radek; Pomeisl, Karel, Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase.. Bioorganic and Medicinal Chemistry Letters 2008, 18(4), 1364 - 1367.

Krecmerova, Marcela; Pohl, Radek; Horska, Kvetoslava; Pomeisl, Karel; Blazek, Jiri, Syntheses of 1-[2-(phosphonomethoxy)alkyl]thymine monophosphates and an evaluation of their inhibitory activity toward human thymidine phosphorylase. Nucleosides, Nucleotides and Nucleic Acids 2012, 31(3), 159 - 171, 10.1080/15257770.2011.648361 .

Cejka, Jan; Pomeisl, Karel; Paleta, Oldrich; Kvicala, Jaroslav; Klasek, Antonin; Kafka, Stanislav; Kubelka, Vladislav; Havlicek, Jaroslav, Limitations of the Wittig-Horner-type annulation of fluorobutenolide moiety to 3-hydroxyquinoline-2,4(2H,3H)-diones. Novel modifications of the Perkow reaction including fluorinated acyloxy leaving groups. Tetrahedron 2007, 63(42), 10549 - 10561, 10.1016/j.tet.2007.07.058 .

Cejka, Jan; Pomeisl, Karel; Paleta, Oldrich; Kvicala, Jaroslav, Synthesis of 3-fluorofuran-2(5H)-ones based on Z/E photoisomerisation and cyclisation of 2-fluoro-4-hydroxybut-2-enoates. European Journal of Organic Chemistry 2007(35), 5917 - 5925, 10.1002/ejoc.200700439 .

Pomeisl, Karel; Paleta, Oldrich; Kvicala, Jaroslav, Convenient synthesis of 3-fluoro-4,5-diphenylfuran-2(5H)-one from benzoin ethers. Novel and efficient Z-E isomerisation and cyclisation of 2-fluoroalkenoate precursors, substitution of vinylic fluorine. Journal of Fluorine Chemistry 2006, 127(10 SPEC. ISS.), 1390 - 1397, 10.1016/j.jfluchem.2006.05.012 .