Detail of compound @ czechem

Molecular Formula: C₂₂H₂₀O₂

Molecular weight: 316.393

InChi: InChI=1S/C22H20O2/c1-4-10-18(11-5-1)22(24-17-21-16-23-21,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15,21H,16-17H2/t21-/m0/s1

InChi Key: XFSXUCMYFWZRAF-NRFANRHFSA-N

SMILES: C(c1ccccc1)(c1ccccc1)(c1ccccc1)OC[C@H]1OC1

Chemical Name
(2S)-2-[(trityloxy)methyl]oxirane
(S)-(-)-glycidyl triphenylmethyl ether
(S)-glycidyl triphenylmethyl ether
(S)-tritylglycidol
(S)-[(triphenylmethoxy)methyl]oxirane
S-(-)-glycidyl trityl ether
[(S)-O-Tritylglycidol]

External Links
PubChem

Authors of compound

Budesinsky, Milos
Krecmerova, Marcela
Holy, Antonin
Dracinsky, Martin
Jansa, Petr
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Hockova, Dana
Pohl, Radek
Klepetarova, Blanka
Cihlar, Tomas
Tloustova, Eva
Clercq, Erik de
Jurikova, Kristina
Smrckova, Svatava
Janeba, Zlatko
Naesens, Lieve
Pomeisl, Karel
Chalupova, Sarka
Piskala, Alois
Neyts, Johan
Tichy, Tomas
Brehova, Petra
Laflamme, Genevieve
Hui, Hon
Baszczynski, Ondrej

Articles

Budesinsky, Milos; Holy, Antonin; Masojidkova, Milena; Hockova, Dana, ACYCLIC NUCLEOSIDE AND NUCLEOTIDE ANALOGS DERIVED FROM 2-AZAADENINE. Collect. Czech. Chem. Commun. 1995, 60(2), 224 - 236, 10.1135/cccc19950224

Holy, Antonin; Jurikova, Kristina; Smrckova, Svatava, SYNTHESIS OF BASE-MODIFIED "ABBREVIATED" NAD ANALOGUES. Collect. Czech. Chem. Commun. 1995, 60(2), 237 - 250, 10.1135/cccc19950237

Holy, Antonin; Masojidkova, Milena; Janeba, Zlatko, Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purin-8(9H)-one. Collect. Czech. Chem. Commun. 2000, 65(7), 1126 - 1144.

Holy, Antonin; Masojidkova, Milena; Janeba, Zlatko, Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purine-8(9H)-thione and 8-(methylsulfanyl)adenine. Collect. Czech. Chem. Commun. 2000, 65(11), 1698 - 1712.

Holy, Antonin; Masojidkova, Milena; Janeba, Zlatko, Synthesis of 8-amino-and N-substituted 8-aminoadenine derivatives of acyclic nucleoside and nucleotide analogs. Collect. Czech. Chem. Commun. 2001, 66(3), 517 - 532, 10.1135/cccc20010517

Holy, Antonin; Masojidkova, Milena; Janeba, Zlatko, Transformation of 8-[(2-hydroxyalkyl)sulfanyl]adenines to 6-amino-7H-purin-8(9H)-one derivatives. Collect. Czech. Chem. Commun. 2001, 66(9), 1393 - 1406, 10.1135/cccc20011393

Holy, Antonin; Votruba, Ivan; Masojidkova, Milena; Tloustova, Eva, Synthesis and cytostatic activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N-substituted adenines, 2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 2001, 66(10), 1545 - 1592.

Holy, Antonin; Votruba, Ivan; Pohl, Radek; Pomeisl, Karel, Simple transformation of thymine 1-[3-hydroxy-2-(phosphonomethoxy)propyl] derivatives to their 1-[3-fluoro-2-(phosphonomethoxy)propyl] counterparts. Collect. Czech. Chem. Commun. 2005, 70(9), 1465 - 1481, 10.1135/cccc2

Holy, Antonin; Masojidkova, Milena; Chalupova, Sarka, Synthesis of some N-substituted derivatives of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, cidofovir). Collect. Czech. Chem. Commun. 2005, 70(12), 2053 - 2065, 10.1135/cccc20052053

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena, Preparation of C-5 substituted cidofovir derivatives. Collect. Czech. Chem. Commun. 2006, 71(4), 579 - 594, 10.1135/cccc20060579

Holy, Antonin; Votruba, Ivan; Pohl, Radek; Pomeisl, Karel, Syntheses of base and side-chain modified pyrimidine 1-[2- (phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Collect. Czech. Chem. Commun. 2006, 71(4), 595 - 624, 10.1135/cccc20060595

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Naesens, Lieve; Piskala, Alois; Neyts, Johan, Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2- (phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry 2007, 50(5), 1069 - 1077, 10.1021/jm061281+

Holy, Antonin; Votruba, Ivan; Pohl, Radek; Pomeisl, Karel, Syntheses of N-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase. Bioorganic and Medicinal Chemistry Letters 2008, 18(4), 1364 - 1367, 10.1016/j.bmcl.2008.01.006

Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena, Pyrimidine acyclic nucleotide analogues with aromatic substituents in C-5 position. Collect. Czech. Chem. Commun. 2007, 72(7), 927 - 951, 10.1135/cccc20070927

Krecmerova, Marcela; Holy, Antonin; Dracinsky, Martin; Masojidkova, Milena; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Pohl, Radek; Cihlar, Tomas; Naesens, Lieve; Pomeisl, Karel; Neyts, Johan; Tichy, Tomas; Brehova, Petra; Laflamme, Genevieve; Hui, Hon, Synthesis of ester prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl] -2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. Journal of Medicinal Chemistry 2010, 53(19), 6825 - 6837, 10.1021/jm901828c

Holy, Antonin; Dracinsky, Martin; Jansa, Petr; Votruba, Ivan; Balzarini, Jan; Klepetarova, Blanka; Clercq, Erik de; Janeba, Zlatko; Baszczynski, Ondrej, Synthesis and antiviral activity of N-[3-fluoro-2- (phosphonomethoxy)propyl] analogues derived from N-substituted adenines and 2,6-diaminopurines. Bioorganic and Medicinal Chemistry 2011, 19(7), 2114 - 2124, 10.1016/j.bmc.2011.02.050

Krecmerova, Marcela; Dracinsky, Martin; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Tichy, Tomas, Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety. Eur. J. Med. Chem. 2012, 55, 307 - 314,8, 10.1016/j.ejmech.2012.07.027

Patents

Krecmerova, Marcela; Holy, Antonin; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Naesens, Lieve; Piskala, Alois; Neyts, Johan, AZACYTOSINE DERIVATIVES USEFUL AS ANTIVIRAL AGENTS, WO2007/65231, 2007.