Molecular Formula: C7H13N4O5P
Molecular weight: 264.175681
InChi: InChI=1S/C7H13N4O5P/c8-5-3-6(11-7(9)10-5)16-2-1-15-4-17(12,13)14/h3H,1-2,4H2,(H2,12,13,14)(H4,8,9,10,11)
InChi Key: GHXCAFKFSYKTJZ-UHFFFAOYSA-N
SMILES: P(=O)(COCCOc1nc(nc(c1)N)N)(O)O
Chemical Name
2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine
2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine
Authors of compound
Krecmerova, Marcela
Holy, Antonin
Dracinsky, Martin
Jansa, Petr
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Hockova, Dana
Mackman, Richard
Cihlar, Tomas
Bahador, Gina
Tloust'Ova, Eva
Janeba, Zlatko
Zidek, Zdenek
Naesens, Lieve
Hajek, Miroslav
Matulova, Nadezda
Lebeau, Ilya
Duraffour, Sophie
Van Den Oord, Joost
De Vos, Rita
Crance, Jean-Marc
Garin, Daniel
Baszczynski, Ondrej
Stepan, George
Antonin, Holy
Jan M. R., Balzarini
Erik D. A., De Clercq
BALZARINI, Jan, Marie, Rene
DE CLERCQ, Erik, Desire, Alice
Holy, Antonin
Dracinsky, Martin
Jansa, Petr
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Hockova, Dana
Mackman, Richard
Cihlar, Tomas
Bahador, Gina
Tloust'Ova, Eva
Janeba, Zlatko
Zidek, Zdenek
Naesens, Lieve
Hajek, Miroslav
Matulova, Nadezda
Lebeau, Ilya
Duraffour, Sophie
Van Den Oord, Joost
De Vos, Rita
Crance, Jean-Marc
Garin, Daniel
Baszczynski, Ondrej
Stepan, George
Antonin, Holy
Jan M. R., Balzarini
Erik D. A., De Clercq
BALZARINI, Jan, Marie, Rene
DE CLERCQ, Erik, Desire, Alice
Articles
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve, 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. Journal of Medicinal Chemistry 2002, 45(9), 1918 - 1929, 10.1021/jm011095y 
.
.
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana, 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy) ethoxy]pyrimidines-Acyclic Nucleoside Phosphonate Analogues with Antiviral Activity. Journal of Medicinal Chemistry 2003, 46(23), 5064 - 5073.
Holy, Antonin;
Votruba, Ivan;
Tloust'Ova, Eva;
Hajek, Miroslav;
Matulova, Nadezda, Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates. Biochemical Pharmacology 2005, 70(6), 894 - 900, 10.1016/j.bcp.2005.06.007 .
.
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana, Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2- (phosphonomethoxy)ethoxy]pyrimidine and related compounds. Bioorganic and Medicinal Chemistry 2004, 12(12), 3197 - 3202, 10.1016/j.bmc.2004.04.002 .
.
Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Lebeau, Ilya, Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Antimicrobial Agents and Chemotherapy 2007, 51(6), 2268 - 2273, 10.1128/AAC.01422-06 .
.
Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Duraffour, Sophie;
Van Den Oord, Joost;
De Vos, Rita;
Crance, Jean-Marc;
Garin, Daniel, Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. Antimicrobial Agents and Chemotherapy 2007, 51(12), 4410 - 4419, 10.1128/AAC.00838-07 .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Votruba, Ivan;
Mackman, Richard;
Cihlar, Tomas;
Bahador, Gina;
Janeba, Zlatko;
Zidek, Zdenek;
Baszczynski, Ondrej;
Stepan, George, A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities. European Journal of Medicinal Chemistry 2011, 46(9), 3748 - 3754, 10.1016/j.ejmech.2011.05.040 .
.
Patents
Antonin, Holy;
Jan M. R., Balzarini;
Erik D. A., De Clercq, Novel compounds and methods for therapy, US2003/109499, 2003.