Molecular Formula: C7H16BrO3P
Molecular weight: 259.077901
InChi: InChI=1S/C7H16BrO3P/c1-6(2)10-12(9,5-8)11-7(3)4/h6-7H,5H2,1-4H3
InChi Key: JNONGIUWXHOEEN-UHFFFAOYSA-N
SMILES: P(=O)(OC(C)C)(OC(C)C)CBr
Chemical Name
(i-PrO)2POCH2Br
(iPrO)2POCH2Br
BrCH2P(O)(OiPr)2
diisopropoxyphosphorylmethyl bromide
diisopropyl (bromomethyl)phosphonate
diisopropyl bromomethanephosphonate
diisopropyl bromomethyl-phosphonate
(i-PrO)2POCH2Br
(iPrO)2POCH2Br
BrCH2P(O)(OiPr)2
diisopropoxyphosphorylmethyl bromide
diisopropyl (bromomethyl)phosphonate
diisopropyl bromomethanephosphonate
diisopropyl bromomethyl-phosphonate
Authors of compound
Krecmerova, Marcela
Holy, Antonin
Dracinsky, Martin
Jansa, Petr
Cesnek, Michal
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Hockova, Dana
Pohl, Radek
Klepetarova, Blanka
Cihlar, Tomas
Clercq, Erik de
Janeba, Zlatko
Naesens, Lieve
Pomeisl, Karel
Dolakova, Petra
Piskala, Alois
Neyts, Johan
Solinova, Veronika
Kasicka, Vaclav
Keough, Dianne T.
Guddat, Luke W.
Tichy, Tomas
Brehova, Petra
Laflamme, Genevieve
Hui, Hon
Jersey, John de
Baszczynski, Ondrej
Stepan, George
Mertlikova-Kaiserova, Helena
Sazelova, Petra
Kolman, Viktor
Kostinova, Alexandra
Auwerx, Joeri
Kiss, Eleonora
Goris, Nesya
Holy, Antonin
Dracinsky, Martin
Jansa, Petr
Cesnek, Michal
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Hockova, Dana
Pohl, Radek
Klepetarova, Blanka
Cihlar, Tomas
Clercq, Erik de
Janeba, Zlatko
Naesens, Lieve
Pomeisl, Karel
Dolakova, Petra
Piskala, Alois
Neyts, Johan
Solinova, Veronika
Kasicka, Vaclav
Keough, Dianne T.
Guddat, Luke W.
Tichy, Tomas
Brehova, Petra
Laflamme, Genevieve
Hui, Hon
Jersey, John de
Baszczynski, Ondrej
Stepan, George
Mertlikova-Kaiserova, Helena
Sazelova, Petra
Kolman, Viktor
Kostinova, Alexandra
Auwerx, Joeri
Kiss, Eleonora
Goris, Nesya
Articles
Holy, Antonin;
Masojidkova, Milena;
Hockova, Dana, Sonogashira cross-coupling in the synthesis of acyclic nucleoside phosphonates: Preparation of 6-[(phosphonomethoxy)alkynyl]- and 6-[(phosphonomethoxy)alkyl]pyrimidines. Collect. Czech. Chem. Commun. 2005, 70(2), 247 - 258, 10.1135/cccc20050247 
.
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve;
Piskala, Alois;
Neyts, Johan, Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2- (phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry 2007, 50(5), 1069 - 1077, 10.1021/jm061281+ .
.
Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Dolakova, Petra;
Solinova, Veronika;
Kasicka, Vaclav, Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines. European Journal of Medicinal Chemistry 2009, 44(6), 2408 - 2424, 10.1016/j.ejmech.2008.09.031 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena, Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position. Bioorganic and Medicinal Chemistry 2010, 18(1), 387 - 395, 10.1016/j.bmc.2009.10.044 .
.
Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Pohl, Radek;
Cihlar, Tomas;
Naesens, Lieve;
Pomeisl, Karel;
Neyts, Johan;
Tichy, Tomas;
Brehova, Petra;
Laflamme, Genevieve;
Hui, Hon, Synthesis of ester prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl] -2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. Journal of Medicinal Chemistry 2010, 53(19), 6825 - 6837, 10.1021/jm901828c .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Votruba, Ivan;
Balzarini, Jan;
Klepetarova, Blanka;
Clercq, Erik de;
Janeba, Zlatko;
Baszczynski, Ondrej, Synthesis and antiviral activity of N-[3-fluoro-2- (phosphonomethoxy)propyl] analogues derived from N-substituted adenines and 2,6-diaminopurines. Bioorganic and Medicinal Chemistry 2011, 19(7), 2114 - 2124, 10.1016/j.bmc.2011.02.050 .
.
Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Cesnek, Michal;
Janeba, Zlatko;
Baszczynski, Ondrej, Efficient and 'green' microwave-assisted synthesis of haloalkylphosphonates via the Michaelis-Arbuzov reaction. Green Chemistry 2011, 13(4), 882 - 888, 10.1039/c0gc00509f .
.
Holy, Antonin;
Dracinsky, Martin;
Cesnek, Michal;
Hockova, Dana;
Keough, Dianne T.;
Guddat, Luke W.;
Jersey, John de;
Baszczynski, Ondrej, Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorganic and Medicinal Chemistry 2012, 20(2), 1076 - 1089, 10.1016/j.bmc.2011.11.034 .
.
Dracinsky, Martin;
Jansa, Petr;
Janeba, Zlatko;
Mertlikova-Kaiserova, Helena;
Kolman, Viktor;
Kostinova, Alexandra, Efficient synthesis and biological properties of the 2'-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates. Collect. Czech. Chem. Commun. 2011, 76(10), 1187 - 1198, 10.1135/cccc2011105 .
.
Krecmerova, Marcela;
Dracinsky, Martin;
Jansa, Petr;
Janeba, Zlatko;
Neyts, Johan;
Kasicka, Vaclav;
Stepan, George;
Sazelova, Petra;
Auwerx, Joeri;
Kiss, Eleonora;
Goris, Nesya, 9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: Optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro. Bioorganic and Medicinal Chemistry 2013, 21(5), 1199 - 1208, 10.1016/j.bmc.2012.12.044 .
.