Molecular Formula: C7H13N4O6P
Molecular weight: 280.175081
InChi: InChI=1S/C7H13N4O6P/c8-6-9-3-11(7(13)10-6)1-5(2-12)17-4-18(14,15)16/h3,5,12H,1-2,4H2,(H2,8,10,13)(H2,14,15,16)/t5-/m0/s1
InChi Key: JEYKGEGRFZIHCQ-YFKPBYRVSA-N
SMILES: P(=O)(CO[C@@H](Cn1c(=O)nc(nc1)N)CO)(O)O
Chemical Name
(S)-1-(3-hydroxy-2-phosphorylmethoxypropyl)-5-azacytosine
(S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine
(S)-HPMP-5-azaC
(S)-HPMP-5-azacytosine
1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine
1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine
HPMP-5-azacytosine
(S)-1-(3-hydroxy-2-phosphorylmethoxypropyl)-5-azacytosine
(S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine
(S)-HPMP-5-azaC
(S)-HPMP-5-azacytosine
1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine
1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine
HPMP-5-azacytosine
Authors of compound
Krecmerova, Marcela
Holy, Antonin
Dracinsky, Martin
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Pohl, Radek
Tloust'Ova, Eva
Naesens, Lieve
Hajek, Miroslav
Piskala, Alois
Neyts, Johan
Lebeau, Ilya
Duraffour, Sophie
Van Den Oord, Joost
De Vos, Rita
Crance, Jean-Marc
Garin, Daniel
Holy, Antonin
Dracinsky, Martin
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Pohl, Radek
Tloust'Ova, Eva
Naesens, Lieve
Hajek, Miroslav
Piskala, Alois
Neyts, Johan
Lebeau, Ilya
Duraffour, Sophie
Van Den Oord, Joost
De Vos, Rita
Crance, Jean-Marc
Garin, Daniel
Articles
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve;
Piskala, Alois;
Neyts, Johan, Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2- (phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry 2007, 50(5), 1069 - 1077, 10.1021/jm061281+ 
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Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Lebeau, Ilya, Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Antimicrobial Agents and Chemotherapy 2007, 51(6), 2268 - 2273, 10.1128/AAC.01422-06 .
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Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Duraffour, Sophie;
Van Den Oord, Joost;
De Vos, Rita;
Crance, Jean-Marc;
Garin, Daniel, Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. Antimicrobial Agents and Chemotherapy 2007, 51(12), 4410 - 4419, 10.1128/AAC.00838-07 .
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Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Pohl, Radek;
Naesens, Lieve;
Neyts, Johan, Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5- azacytosine: Synthesis and antiviral activity. Journal of Medicinal Chemistry 2007, 50(23), 5765 - 5772, 10.1021/jm0707166 .
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Krecmerova, Marcela;
Holy, Antonin;
Votruba, Ivan;
Tloust'Ova, Eva;
Hajek, Miroslav, Alpha anomer of 5-aza-2′-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells. Biochemical Pharmacology 2008, 75(4), 965 - 972, 10.1016/j.bcp.2007.10.018 .
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Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin, Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy. Bioorganic and Medicinal Chemistry 2008, 16(14), 6778 - 6782, 10.1016/j.bmc.2008.05.058 .
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Krecmerova, Marcela;
Holy, Antonin;
Votruba, Ivan;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Naesens, Lieve;
Neyts, Johan, Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. Biochemical Pharmacology 2008, 76(8), 997 - 1005, 10.1016/j.bcp.2008.08.009 .
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Krecmerova, Marcela;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Pohl, Radek, N-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: Chemistry and antiviral activity. Bioorganic and Medicinal Chemistry 2014, 22(10), 2896 - 2906, 10.1016/j.bmc.2014.03.031 .
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