Molecular Formula: C9H13N4O5P
Molecular weight: 288.197081
InChi: InChI=1S/C9H13N4O5P/c14-9-7-8(10-5-11-9)13(6-12-7)1-2-18-3-4-19(15,16)17/h5-6H,1-4H2,(H,10,11,14)(H2,15,16,17)
InChi Key: ARUATFPHVPUVFJ-UHFFFAOYSA-N
SMILES: c12c(c(=O)[nH]cn2)ncn1CCOCCP(=O)(O)O
Authors of compound
Krecmerova, Marcela
Holy, Antonin
Dracinsky, Martin
Cesnek, Michal
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
Hockova, Dana
Slavetinska, Lenka
Janeba, Zlatko
Naesens, Lieve
Vrbkova, Silvie
Keough, Dianne T.
De Jersey, John
Guddat, Luke W.
Tichy, Tomas
Jersey, John de
Baszczynski, Ondrej
Rejman, Dominik
Spacek, Petr
Wang, Tzu-Hsuan
Edstein, Michael D.
Chavchich, Marina
Eng, Wai Soon
Jans, Harmen
West, Nicholas P.
Naesens, Lieve M.J.
Holy, Antonin
Dracinsky, Martin
Cesnek, Michal
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
Hockova, Dana
Slavetinska, Lenka
Janeba, Zlatko
Naesens, Lieve
Vrbkova, Silvie
Keough, Dianne T.
De Jersey, John
Guddat, Luke W.
Tichy, Tomas
Jersey, John de
Baszczynski, Ondrej
Rejman, Dominik
Spacek, Petr
Wang, Tzu-Hsuan
Edstein, Michael D.
Chavchich, Marina
Eng, Wai Soon
Jans, Harmen
West, Nicholas P.
Naesens, Lieve M.J.
Articles
Holy, Antonin;
Masojidkova, Milena;
Hockova, Dana;
Keough, Dianne T.;
Guddat, Luke W.;
Jersey, John de, Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorganic and Medicinal Chemistry 2009, 17(17), 6218 - 6232, 10.1016/j.bmc.2009.07.044 
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Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Hockova, Dana, Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity. Bioorganic and Medicinal Chemistry 2011, 19(15), 4445 - 4453, 10.1016/j.bmc.2011.06.045 .
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Holy, Antonin;
Dracinsky, Martin;
Cesnek, Michal;
Hockova, Dana;
Keough, Dianne T.;
Guddat, Luke W.;
Jersey, John de;
Baszczynski, Ondrej, Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorganic and Medicinal Chemistry 2012, 20(2), 1076 - 1089, 10.1016/j.bmc.2011.11.034 .
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Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Hockova, Dana;
Keough, Dianne T.;
Guddat, Luke W., Synthesis of purine N-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorganic and Medicinal Chemistry 2012, 20(3), 1222 - 1230, 10.1016/j.bmc.2011.12.034 .
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Hockova, Dana;
Janeba, Zlatko;
Keough, Dianne T.;
De Jersey, John;
Guddat, Luke W.;
Wang, Tzu-Hsuan, Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry 2012, 55(13), 6209 - 6223, 10.1021/jm300662d .
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Hockova, Dana;
Slavetinska, Lenka;
Janeba, Zlatko;
Naesens, Lieve;
Vrbkova, Silvie;
Keough, Dianne T.;
De Jersey, John;
Guddat, Luke W.;
Tichy, Tomas;
Spacek, Petr;
Wang, Tzu-Hsuan;
Edstein, Michael D.;
Chavchich, Marina, Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. Journal of Medicinal Chemistry 2013, 56(6), 2513 - 2526, 10.1021/jm301893b .
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Krecmerova, Marcela;
Hockova, Dana;
Vrbkova, Silvie;
Keough, Dianne T.;
De Jersey, John;
Guddat, Luke W.;
Rejman, Dominik;
Spacek, Petr;
Eng, Wai Soon;
Jans, Harmen;
West, Nicholas P.;
Naesens, Lieve M.J., Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: Potential for new antibacterial agents. Journal of Medicinal Chemistry 2013, 56(17), 6967 - 6984, 10.1021/jm400779n .
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