Detail of compound @ czechem

Molecular Formula: C₆H₇BO₂

Molecular weight: 121.92958

InChi: InChI=1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H

InChi Key: HXITXNWTGFUOAU-UHFFFAOYSA-N

SMILES: c1(B(O)O)ccccc1

Chemical Name
3,4,5-trimethoxyphenylboronic acid
benzene boronic acid
Benzeneboronic acid
dihydroxy-phenylborane
dihydroxyphenylborane
Ph-B(OH)2
Phenylboronic acid

External Links
PubChem

Authors of compound

Cisarova, Ivana
Naus, Petr
Bures, Filip
Kulhanek, Jiri
Pytela, Oldrich
Marek, Ales
Ruzicka, Ales
Mikysek, Tomas
Ludvik, Jiri
Reznicek, Tomas
Dostal, Libor
Jambor, Roman
Holy, Antonin
Dracinsky, Martin
Cibulka, Radek
Hampl, Frantisek
Kotoucova, Hana
Jurok, Radek
Dvorakova, Hana
Menova, Petra
Hodacova, Jana
Stibor, Ivan
Eigner, Vaclav
Cejka, Jan
Setnicka, Vladimir
Strnadova, Iveta
Kovandova, Martina
Chudoba, Josef
Keder, Roman
Jansa, Petr
Dvorak, Dalimil
Saman, David
Stary, Ivo
Havelkova, Martina
Hocek, Michal
Cesnek, Michal
Tobrman, Tomas
Klecka, Martin
Votruba, Ivan
Potacek, Milan
Masojidkova, Milena
Hockova, Dana
Stara, Irena G.
Stambasky, Jan
Capek, Petr
Pohl, Radek
Klepetarova, Blanka
Silhar, Peter
Urban, Milan
Cerna, Igor
Shih, I-hung
Mabery, Eric
Mackman, Richard
Kuchar, Martin
Vrabel, Milan
Hasnik, Zbynek
Joubert, Nicolas
Cahova, Hana
Barta, Jan
Ernsting, Nikolaus P.
Otmar, Miroslav
Bednarova, Lucie
Novakova, Katerina
Cvacka, Josef
Bambuch, Vitezslav
Stefko, Martin
Klepetaova, Blanka
Cernova, Miroslava
Slavetinska, Lenka
Dzubak, Petr
Hajduch, Marian
Ameral, Ria
Birkus, Gabriel
Wang, Ting
Ray, Adrian S.
Cihlar, Tomas
Raindlova, Veronika
Kubelka, Tomas
Snasel, Jan
Pichova, Iva
Perlikova, Pavla
Shih, Robert
Bourderioux, Aurelie
Konecny, Petr
Stray, Kirsten M.
Feng, Joy Y.
Kysilka, Ondrej
Kubelka, Toma
Slavtinska, Lenka
Jornet Martinez, Neus
Bahador, Gina
Tichy, Michal
Xu, Hao Ying
Chen, Yen-Liang
Yokokawa, Fumiaki
Shi, Pei-Yong
Eberlin, Ludovic
Tloustova, Eva
Lee, Yu-Jen
Tloust'Ova, Eva
Weber, Jan
Caletkova, Olga
Bogdanova, Katerina
Kolar, Milan
Vrbkova, Jana
Horska, Kvetoslava
Janeba, Zlatko
Zidek, Zdenek
Kmonickova, Eva
Pomeisl, Karel
Brehova, Petra
Sedlacek, Ondrej
Kvicala, Jaroslav
Skalicky, Martin
Sykora, Jan
Rybackova, Marketa
Kvicalova, Magdalena
Lhotak, Pavel
Budka, Jan
Man, Stanislav
Tenora, Lukas
Galeta, Juraj
Kollarovic, Adrian
Misek, Jiri
Songis, Olivier
Schmid, Markus B.

Articles

Bures, Filip; Kulhanek, Jiri; Marek, Ales, Design and efficient synthesis of amino acid derived 2-substituted imidazoles by palladium-catalyzed cross-coupling reactions. Synthesis 2009(2), 325 - 331, 10.1055/s-0028-1083263

Bures, Filip; Kulhanek, Jiri; Pytela, Oldrich; Ruzicka, Ales; Mikysek, Tomas; Ludvik, Jiri, Push-pull molecules with a systematically extended π-conjugated system featuring 4,5-dicyanoimidazole. Dyes and Pigments 2010, 85(1-2), 57 - 65, 10.1016/j.dyepig.2009.10.004

Bures, Filip; Kulhanek, Jiri; Ruzicka, Ales; Reznicek, Tomas; Dostal, Libor; Jambor, Roman, Palladium(II) complexes of Y,C,Y-chelated phosphines: Synthesis, structure, and catalytic activity in Suzuki-Miyaura reaction. Applied Organometallic Chemistry 2011, 25(3), 173 - 179, 10.1002/aoc.1737

Cibulka, Radek; Hampl, Frantisek; Jurok, Radek; Dvorakova, Hana; Hodacova, Jana, Planar chiral flavinium salts - Prospective catalysts for enantioselective sulfoxidation reactions. European Journal of Organic Chemistry 2010(27), 5217 - 5224, 10.1002/ejoc.201000592

Cibulka, Radek; Jurok, Radek; Dvorakova, Hana; Hodacova, Jana; Eigner, Vaclav; Setnicka, Vladimir, Planar chiral flavinium salts: Synthesis and evaluation of the effect of substituents on the catalytic efficiency in enantioselective sulfoxidation reactions. European Journal of Organic Chemistry 2013(34), 7724 - 7738, 10.1002/ejoc.201300847

Cibulka, Radek; Kotoucova, Hana; Dvorakova, Hana; Strnadova, Iveta; Kovandova, Martina; Chudoba, Josef, Biomimetic aerobic oxidative hydroxylation of arylboronic acids to phenols catalysed by a flavin derivative. Organic and Biomolecular Chemistry 2014, 12(13), 2137 - 2142, 10.1039/c3ob42081g

Dvorak, Dalimil; Havelkova, Martina; Hocek, Michal; Cesnek, Michal, The Suzuki-Miyaura cross-coupling reactions of 6-halopurines with boronic acids leading to 6-aryl- and 6-alkenylpurines. Synlett 1999(7), 1145 - 1147.

Dvorak, Dalimil; Tobrman, Tomas, Reductive dimerization of 2- and 6-iodopurines: Side reaction in Pd-catalyzed cross-coupling of iodopurines. Collect. Czech. Chem. Commun. 2007, 72(10), 1365 - 1374, 10.1135/cccc20071365

Dvorakova, Hana; Keder, Roman; Dvorak, Dalimil, New Approach to the Synthesis of N-Arylguanines and N -Aryladenlnes. European Journal of Organic Chemistry 2009(10), 1522 - 1531, 10.1002/ejoc.200801002

Dvorak, Dalimil; Tobrman, Tomas, Regioselective and facile synthesis of 7,9-dialkyl-8-oxopurines from 7,9-dialkyl-7,8-dihydropurines: Total synthesis of heteromines i and J. Synthesis 2014, 46(5), 660 - 668, 10.1055/s-0033-1340499

Holy, Antonin; Dvorakova, Hana; Hocek, Michal; Votruba, Ivan, Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: Application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids. Journal of Medicinal Chemistry 2000, 43(9), 1817 - 1825, 10.1021/jm991167+

Holy, Antonin; Dvorakova, Hana; Hocek, Michal; Votruba, Ivan, Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-β-D-erythro-pentofuranosyl)-, 9-(5-deoxy-β-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines. Collect. Czech. Chem. Commun. 2000, 65(11), 1683 - 1697.

Holy, Antonin; Hocek, Michal; Cesnek, Michal, Synthesis of acyclic nucleotide analogues derived from 2-amino-6-C-substituted purines via cross-coupling reactions of 2-amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-halopurines with diverse organometallic reagents. Collect. Czech. Chem. Commun. 2000, 65(8), 1357 - 1373.

Holy, Antonin; Dvorakova, Hana; Hocek, Michal, Cytostatic 6-arylpurine nucleosides IV. Synthesis of 2-substituted 6-phenylpurine ribonucleosides. Collect. Czech. Chem. Commun. 2002, 67(3), 325 - 335, 10.1135/cccc20020325

Hocek, Michal; Hockova, Dana; Stambasky, Jan, Cytostatic 6-arylpurine nucleosides V. synthesis of 8-substituted 6-phenylpurine ribonucleosides. Collect. Czech. Chem. Commun. 2003, 68(5), 837 - 848, 10.1135/cccc20030837

Dvorakova, Hana; Hocek, Michal, An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines. Journal of Organic Chemistry 2003, 68(14), 5773 - 5776, 10.1021/jo034351i

Dvorakova, Hana; Hocek, Michal; Hockova, Dana, Dichotomy in regioselective cross-coupling reactions of 6,8-dichloropurines with phenylboronic acid and methylmagnesium chloride: Synthesis of 6,8-di-substituted purines. Synthesis 2004(6), 889 - 894.

Hocek, Michal; Pohl, Radek, Regioselectivity in cross-coupling reactions of 2,6,8-trichloro-9- (tetrahydropyran-2-yl)purine: Synthesis of 2,6,8-trisubstituted purine bases. Synthesis 2004(17), 2869 - 2876, 10.1055/s-2004-834881

Hocek, Michal; Pohl, Radek; Klepetarova, Blanka; Urban, Milan, New modular and efficient approach to 6-substituted pyridin-2-yl C-nucleosides. Journal of Organic Chemistry 2006, 71(19), 7322 - 7328, 10.1021/jo061080d

Hocek, Michal; Pohl, Radek; Klepetarova, Blanka; Cerna, Igor, Direct C-H arylation of purines: Development of methodology and its use in regioselective synthesis of 2,6,8-trisubstituted purines. Organic Letters 2006, 8(23), 5389 - 5392, 10.1021/ol062324j

Hocek, Michal; Silhar, Peter; Shih, I-hung; Mabery, Eric; Mackman, Richard, Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: Synthesis and evaluation of 6-substituted purine l-ribonucleosides. Bioorganic and Medicinal Chemistry Letters 2006, 16(20), 5290 - 5293, 10.1016/j.bmcl.2006.07.092

Hocek, Michal; Votruba, Ivan; Pohl, Radek; Klepetarova, Blanka; Silhar, Peter, Synthesis of 6-amino-, 6-methyl- and 6-aryl-2-(hydroxymethyl)purine bases and nucleosides. Collect. Czech. Chem. Commun. 2006, 71(6), 788 - 803, 10.1135/cccc20060788

Hocek, Michal; Capek, Petr; Pohl, Radek; Vrabel, Milan; Hasnik, Zbynek, Aqueous-phase Suzuki-Miyaura cross-coupling reactions of free halopurine bases. Synthesis 2006(20), 3515 - 3526, 10.1055/s-2006-950240

Hocek, Michal; Pohl, Radek; Klepetarova, Blanka; Joubert, Nicolas, Modular and practical synthesis of 6-substituted pyridin-3-yl C-nucleosides. Journal of Organic Chemistry 2007, 72(18), 6797 - 6805, 10.1021/jo0709504

Hocek, Michal; Pohl, Radek; Silhar, Peter, Cytostatic and antiviral 6-arylpurine ribonucleosides VIII. Synthesis and evaluation of 6-substituted purine 3′-deoxyribonucleosides. Collect. Czech. Chem. Commun. 2006, 71(10), 1484 - 1496, 10.1135/cccc20061484

Hocek, Michal; Pohl, Radek; Klepetarova, Blanka; Barta, Jan; Ernsting, Nikolaus P., Modular synthesis of 5-substituted thiophen-2-yl C-2′- deoxyribonucleosides. Journal of Organic Chemistry 2008, 73(10), 3798 - 3806, 10.1021/jo800177y

Hocek, Michal; Pohl, Radek; Cahova, Hana; Bednarova, Lucie; Novakova, Katerina; Cvacka, Josef, Synthesis of 8-bromo-, 8-methyl- and 8-phenyl-dATP and their polymerase incorporation into DNA. Organic and Biomolecular Chemistry 2008, 6(20), 3657 - 3660, 10.1039/b811935j

Naus, Petr; Hocek, Michal; Kuchar, Martin, Cytostatic and antiviral 6-arylpurine ribonucleosides IX. Synthesis and evaluation of 6-substituted 3-deazapurine ribonucleosides. Collect. Czech. Chem. Commun. 2008, 73(5), 665 - 678, 10.1135/cccc20080665

Hocek, Michal; Klecka, Martin; Pohl, Radek; Klepetaova, Blanka, Direct C-H borylation and C-H arylation of pyrrolo2,3-dpyrimidines: Synthesis of 6,8-disubstituted 7-deazapurines. Organic and Biomolecular Chemistry 2009, 7(5), 866 - 868, 10.1039/b900218a

Hocek, Michal; Klepetarova, Blanka; Stefko, Martin; Slavetinska, Lenka, A general and efficient synthesis of pyridin-2-yl C-ribonucleosides bearing diverse alkyl, aryl, amino, and carbamoyl groups in position 6. Journal of Organic Chemistry 2010, 75(2), 442 - 449, 10.1021/jo902313g

Naus, Petr; Hocek, Michal; Votruba, Ivan; Pohl, Radek; Mackman, Richard; Dzubak, Petr; Hajduch, Marian; Ameral, Ria; Birkus, Gabriel; Wang, Ting; Ray, Adrian S.; Cihlar, Tomas, 6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents. Journal of Medicinal Chemistry 2010, 53(1), 460 - 470, 10.1021/jm901428k

Hocek, Michal; Klepetarova, Blanka; Slavetinska, Lenka; Kubelka, Tomas, Synthesis of 2,4-disubstituted pyrimidin-5-yl C-2′- deoxyribonucleosides by sequential regioselective reactions of 2,4-dichloropyrimidine nucleosides. European Journal of Organic Chemistry 2010(14), 2666 - 2669, 10.1002/ejoc.201000164

Hocek, Michal; Votruba, Ivan; Pohl, Radek; Birkus, Gabriel; Cihlar, Tomas; Perlikova, Pavla; Shih, Robert, Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides. Bioorganic and Medicinal Chemistry 2011, 19(1), 229 - 242, 10.1016/j.bmc.2010.11.029

Naus, Petr; Hocek, Michal; Votruba, Ivan; Pohl, Radek; Dzubak, Petr; Hajduch, Marian; Birkus, Gabriel; Wang, Ting; Ray, Adrian S.; Cihlar, Tomas; Pichova, Iva; Perlikova, Pavla; Bourderioux, Aurelie; Konecny, Petr; Stray, Kirsten M.; Feng, Joy Y., Synthesis and significant cytostatic activity of 7-hetaryl-7- deazaadenosines. Journal of Medicinal Chemistry 2011, 54(15), 5498 - 5507, 10.1021/jm2005173

Hocek, Michal; Kubelka, Toma; Slavtinska, Lenka, A general regioselective approach to 2,4-disubstituted pyrimidin-5-yl C-2-deoxyribonucleosides. Synthesis 2012, 44(6), 953 - 965, 10.1055/s-0031-1289694

Naus, Petr; Hocek, Michal; Pohl, Radek; Perlikova, Pavla, Sugar-modified derivatives of cytostatic 6-(het)aryl-7-deazapurine nucleosides: 2′-c-methylribonucleosides, arabinonucleosides and 2′-deoxy-2′-fluoroarabinonucleosides. Collect. Czech. Chem. Commun. 2011, 76(8), 957 - 988, 10.1135/cccc2011082

Hocek, Michal; Pohl, Radek; Klepetarova, Blanka; Cernova, Miroslava, A general regioselective synthesis of 2,4-diarylpyrimidines from 2-thiouracil through two orthogonal cross-coupling reactions. Synlett 2012, 23(9), 1305 - 1308, 10.1055/s-0031-1290826

Hocek, Michal; Perlikova, Pavla; Slavtinska, Lenka; Jornet Martinez, Neus, Synthesis of 2′-deoxy-2′-fluororibo- and 2′-deoxy- 2′,2′-difluororibonucleosides derived from 6-(het)aryl-7- deazapurines. Tetrahedron 2012, 68(39), 8300 - 8310, 10.1016/j.tet.2012.07.033

Naus, Petr; Hocek, Michal; Votruba, Ivan; Pohl, Radek; Slavetinska, Lenka; Birkus, Gabriel; Cihlar, Tomas; Perlikova, Pavla; Bourderioux, Aurelie; Bahador, Gina, Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′- fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides. Bioorganic and Medicinal Chemistry 2012, 20(17), 5202 - 5214, 10.1016/j.bmc.2012.07.003

Hocek, Michal; Pohl, Radek; Tichy, Michal; Xu, Hao Ying; Chen, Yen-Liang; Yokokawa, Fumiaki; Shi, Pei-Yong, Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides. Bioorganic and Medicinal Chemistry 2012, 20(20), 6123 - 6133,11, 10.1016/j.bmc.2012.08.021

Hocek, Michal; Slavetinska, Lenka; Kubelka, Tomas, Synthesis of substituted benzyl homo-C-ribonucleosides and -nucleotides as carba analogues of phosphoribosylanthranilate. European Journal of Organic Chemistry 2012(26), 4969 - 4981, 10.1002/ejoc.201200819

Eigner, Vaclav; Hocek, Michal; Slavetinska, Lenka; Kubelka, Tomas, Synthesis of 2,6-disubstituted pyridin-3-yl C-2′-deoxyribonucleosides through chemoselective transformations of bromo-chloropyridine C-nucleosides. Organic and Biomolecular Chemistry 2013, 11(28), 4702 - 4718, 10.1039/c3ob40774h

Cejka, Jan; Hocek, Michal; Klecka, Martin; Pohl, Radek, Direct C-H sulfenylation of purines and deazapurines. Organic and Biomolecular Chemistry 2013, 11(31), 5189 - 5193, 10.1039/c3ob40881g

Menova, Petra; Hocek, Michal; Slavetinska, Lenka; Raindlova, Veronika; Perlikova, Pavla; Bahador, Gina; Eberlin, Ludovic; Tloustova, Eva; Lee, Yu-Jen, Synthesis and Cytostatic and Antiviral Activities of 2′-Deoxy-2′,2′-difluororibo- and 2′-Deoxy-2′-fluororibonucleosides Derived from 7-(Het)aryl-7-deazaadenines. ChemMedChem 2013, 8(5), 832 - 846, 10.1002/cmdc.201300047

Hocek, Michal; Pohl, Radek; Bahador, Gina; Tichy, Michal; Lee, Yu-Jen; Tloust'Ova, Eva; Weber, Jan, Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides. Bioorganic and Medicinal Chemistry 2013, 21(17), 5362 - 5372, 10.1016/j.bmc.2013.06.011

Naus, Petr; Hocek, Michal; Votruba, Ivan; Dzubak, Petr; Hajduch, Marian; Snasel, Jan; Pichova, Iva; Perlikova, Pavla; Konecny, Petr, 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents. MedChemComm 2013, 4(11), 1497 - 1500, 10.1039/c3md00232b

Naus, Petr; Hocek, Michal; Slavetinska, Lenka; Dzubak, Petr; Hajduch, Marian; Perlikova, Pavla; Konecny, Petr; Tloust'Ova, Eva; Caletkova, Olga; Bogdanova, Katerina; Kolar, Milan; Vrbkova, Jana, Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides. Journal of Medicinal Chemistry 2014, 57(3), 1097 - 1110, 10.1021/jm4018948

Holy, Antonin; Masojidkova, Milena; Pohl, Radek; Otmar, Miroslav; Bambuch, Vitezslav, C-Functionalization of 9-deazapurines by cross-coupling reactions. Tetrahedron 2007, 63(7), 1589 - 1601, 10.1016/j.tet.2006.12.008

Holy, Antonin; Pohl, Radek; Pomeisl, Karel, Pd-catalyzed Suzuki-Miyaura coupling reactions in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase. Tetrahedron Letters 2007, 48(17), 3065 - 3067, 10.1016/j.tetlet.2007.02.107

Holy, Antonin; Pohl, Radek; Horska, Kvetoslava; Pomeisl, Karel, Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase. Tetrahedron 2009, 65(41), 8486 - 8492, 10.1016/j.tet.2009.08.039

Holy, Antonin; Pohl, Radek; Janeba, Zlatko; Brehova, Petra; Sedlacek, Ondrej, The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy) ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions. Canadian Journal of Chemistry 2011, 89(4), 488 - 498, 10.1139/V11-001

Holy, Antonin; Dracinsky, Martin; Cesnek, Michal; Janeba, Zlatko; Brehova, Petra, The efficient synthesis of 2-arylpyrimidine acyclic nucleoside phosphonates using Liebeskind-Srogl cross-coupling reaction. Tetrahedron 2011, 67(38), 7379 - 7385, 10.1016/j.tet.2011.07.040

Cejka, Jan; Cvacka, Josef; Kysilka, Ondrej; Kvicala, Jaroslav; Skalicky, Martin; Rybackova, Marketa; Kvicalova, Magdalena, Synthesis of bis(polyfluoroalkylated)imidazolium salts as key intermediates for fluorous NHC ligands. Journal of Fluorine Chemistry 2009, 130(10), 966 - 973, 10.1016/j.jfluchem.2009.07.015

Cisarova, Ivana; Stibor, Ivan; Sykora, Jan; Lhotak, Pavel; Budka, Jan, Two structural types of 1,3-alternate tetrapropoxycalix[4]arene derivatives in the solid state. Organic and Biomolecular Chemistry 2005, 3(14), 2572 - 2578, 10.1039/b505454k

Potacek, Milan; Man, Stanislav; Tenora, Lukas; Galeta, Juraj, Dihydropyrrolo[1,2-b]pyrazoles: Withasomnine and related compounds. Tetrahedron 2013, 69(34), 7139 - 7146, 10.1016/j.tet.2013.06.009

Cisarova, Ivana; Saman, David; Stary, Ivo; Stara, Irena G.; Kollarovic, Adrian; Misek, Jiri; Songis, Olivier; Schmid, Markus B., A versatile synthesis of functionalized pentahelicenes. Journal of Organic Chemistry 2010, 75(20), 6889 - 6899, 10.1021/jo1013977

Patents

Naus, Petr; Hocek, Michal, NOVEL CYTOSTATIC 7-DEAZAPURINE NUCLEOSIDES, WO2009/89804, 2009.

Naus, Petr; Hocek, Michal; Bourderioux, Aurelie, NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES, WO2010/121576, 2010.

Holy, Antonin; Jansa, Petr; Janeba, Zlatko; Zidek, Zdenek; Kmonickova, Eva, PYRIMIDINE COMPOUNDS INHIBITING THE FORMATION OF NITRIC OXIDE AND PROSTAGLANDIN E2, METHOD OF PRODUCTION THEREOF AND USE THEREOF, WO2012/116666, 2012.