Molecular Formula: C9H20ClO4P
Molecular weight: 258.679461
InChi: InChI=1S/C9H20ClO4P/c1-8(2)13-15(11,14-9(3)4)7-12-6-5-10/h8-9H,5-7H2,1-4H3
InChi Key: FLCGYFRJKHYTSU-UHFFFAOYSA-N
SMILES: P(=O)(OC(C)C)(OC(C)C)COCCCl
Chemical Name
2-[(diisopropoxyphosphoryl)methoxy]ethyl chloride
bis(2-propyl) <(2-chloroethoxy)methyl>phosphonate
bis(2-propyl) 2-chloroethoxymethanephosphonate
bis(2-propyl) 2-chloroethoxymethylphosphonate
diisopropyl (2-chloroethoxy)methylphosphonate
Diisopropyl [(2-chloroethoxy)methyl]phosphonate
PME-Cl
2-[(diisopropoxyphosphoryl)methoxy]ethyl chloride
bis(2-propyl) <(2-chloroethoxy)methyl>phosphonate
bis(2-propyl) 2-chloroethoxymethanephosphonate
bis(2-propyl) 2-chloroethoxymethylphosphonate
diisopropyl (2-chloroethoxy)methylphosphonate
Diisopropyl [(2-chloroethoxy)methyl]phosphonate
PME-Cl
Authors of compound
Podlaha, Jaroslav
Cisarova, Ivana
Budesinsky, Milos
Krecmerova, Marcela
Holy, Antonin
Jindrich, Jindrich
Dracinsky, Martin
Dvorakova, Hana
Hocek, Michal
Cesnek, Michal
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Hockova, Dana
Pohl, Radek
Tloustova, Eva
Rosenberg, Ivan
Clercq, Erik de
Guenter, Jaroslav
Janeba, Zlatko
Andrei, Graciella
Naesens, Lieve
Pomeisl, Karel
Dolakova, Petra
Piskala, Alois
Neyts, Johan
Solinova, Veronika
Kasicka, Vaclav
Brehova, Petra
Sedlacek, Ondrej
Antonin, Holy
Jan M. R., Balzarini
Erik D. A., De Clercq
Protivinska, Eva
Collinsova, Michaela
Jiracek, Jiri
Netusilova, Hana
Garrow, Timothy A.
Cisarova, Ivana
Budesinsky, Milos
Krecmerova, Marcela
Holy, Antonin
Jindrich, Jindrich
Dracinsky, Martin
Dvorakova, Hana
Hocek, Michal
Cesnek, Michal
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Hockova, Dana
Pohl, Radek
Tloustova, Eva
Rosenberg, Ivan
Clercq, Erik de
Guenter, Jaroslav
Janeba, Zlatko
Andrei, Graciella
Naesens, Lieve
Pomeisl, Karel
Dolakova, Petra
Piskala, Alois
Neyts, Johan
Solinova, Veronika
Kasicka, Vaclav
Brehova, Petra
Sedlacek, Ondrej
Antonin, Holy
Jan M. R., Balzarini
Erik D. A., De Clercq
Protivinska, Eva
Collinsova, Michaela
Jiracek, Jiri
Netusilova, Hana
Garrow, Timothy A.
Articles
Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena, SYNTHESIS OF ACYCLIC NUCLEOTIDE ANALOGUES DERIVED FROM 2-(AMINOMETHYL)ADENINE AND 2-(AMINOMETHYL)HYPOXANTHINE. Collect. Czech. Chem. Commun. 1995, 60(5), 875 - 882, 10.1135/cccc19950875 
.
.
Holy, Antonin;
Hocek, Michal;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik, Synthesis and antiviral activity of acyclic nucleotide analogues derived from 6-(aminomethyl)purines and purine-6-carboxamidines. Collect. Czech. Chem. Commun. 1996, 61(10), 1525 - 1537, 10.1135/cccc19961525 .
.
Holy, Antonin;
Dvorakova, Hana, SYNTHESIS AND BIOLOGICAL EFFECTS OF N-(2-PHOSPHONO-METHOXYETHYL) DERIVATIVES OF DEAZAPURINE BASES. Collect. Czech. Chem. Commun. 1993, 58, 1419 - 1429, 10.1135/cccc19931419 .
.
Budesinsky, Milos;
Holy, Antonin;
Masojidkova, Milena;
Hockova, Dana, ACYCLIC NUCLEOSIDE AND NUCLEOTIDE ANALOGS DERIVED FROM 2-AZAADENINE. Collect. Czech. Chem. Commun. 1995, 60(2), 224 - 236, 10.1135/cccc19950224 .
.
Budesinsky, Milos;
Holy, Antonin;
Jindrich, Jindrich;
Dvorakova, Hana;
Masojidkova, Milena;
Balzarini, Jan;
De Clercq, Erik;
Andrei, Graciella, Acyclic nucleotide analogs derived from 8-azapurines: Synthesis and antiviral activity. Journal of Medicinal Chemistry 1996, 39(20), 4073 - 4088, 10.1021/jm960314q .
.
Podlaha, Jaroslav;
Cisarova, Ivana;
Budesinsky, Milos;
Holy, Antonin, Synthesis of quaternary 1-[2-(phosphonomethoxy)ethyl] derivatives of 2,4-diaminopyrimidine and related acyclic nucleotide analogs. Collect. Czech. Chem. Commun. 1999, 64(2), 242 - 256.
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Guenter, Jaroslav, Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. Journal of Medicinal Chemistry 1999, 42(12), 2064 - 2086, 10.1021/jm9811256 .
.
Holy, Antonin;
Masojidkova, Milena;
Janeba, Zlatko, Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purin-8(9H)-one. Collect. Czech. Chem. Commun. 2000, 65(7), 1126 - 1144.
Holy, Antonin;
Masojidkova, Milena;
Janeba, Zlatko, Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purine-8(9H)-thione and 8-(methylsulfanyl)adenine. Collect. Czech. Chem. Commun. 2000, 65(11), 1698 - 1712.
Holy, Antonin;
Masojidkova, Milena;
Janeba, Zlatko, Synthesis of 8-amino-and N-substituted 8-aminoadenine derivatives of acyclic nucleoside and nucleotide analogs. Collect. Czech. Chem. Commun. 2001, 66(3), 517 - 532, 10.1135/cccc20010517 .
.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Tloustova, Eva, Synthesis and cytostatic activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N-substituted adenines, 2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 2001, 66(10), 1545 - 1592.
Holy, Antonin;
Cesnek, Michal;
Masojidkova, Milena, 6-Guanidinopurine nucleosides and their analogues. Tetrahedron 2002, 58(15), 2985 - 2996, 10.1016/S0040-4020(02)00186-2 .
.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve, 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. Journal of Medicinal Chemistry 2002, 45(9), 1918 - 1929, 10.1021/jm011095y .
.
Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Syntheses of base and side-chain modified pyrimidine 1-[2- (phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Collect. Czech. Chem. Commun. 2006, 71(4), 595 - 624, 10.1135/cccc20060595 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve;
Piskala, Alois;
Neyts, Johan, Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2- (phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry 2007, 50(5), 1069 - 1077, 10.1021/jm061281+ .
.
Holy, Antonin;
Pohl, Radek;
Pomeisl, Karel, Pd-catalyzed Suzuki-Miyaura coupling reactions in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase. Tetrahedron Letters 2007, 48(17), 3065 - 3067, 10.1016/j.tetlet.2007.02.107 .
.
Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Syntheses of N-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase. Bioorganic and Medicinal Chemistry Letters 2008, 18(4), 1364 - 1367, 10.1016/j.bmcl.2008.01.006 .
.
Holy, Antonin;
Dracinsky, Martin;
Masojidkova, Milena;
Dolakova, Petra;
Solinova, Veronika;
Kasicka, Vaclav, Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines. European Journal of Medicinal Chemistry 2009, 44(6), 2408 - 2424, 10.1016/j.ejmech.2008.09.031 .
.
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Pohl, Radek;
Clercq, Erik de;
Janeba, Zlatko, Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base. Canadian Journal of Chemistry 2010, 88(7), 628 - 638, 10.1139/V10-054 .
.
Holy, Antonin;
Pohl, Radek;
Janeba, Zlatko;
Brehova, Petra;
Sedlacek, Ondrej, The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy) ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions. Canadian Journal of Chemistry 2011, 89(4), 488 - 498, 10.1139/V11-001 .
.
Holy, Antonin;
Dracinsky, Martin;
Cesnek, Michal;
Janeba, Zlatko;
Brehova, Petra, The efficient synthesis of 2-arylpyrimidine acyclic nucleoside phosphonates using Liebeskind-Srogl cross-coupling reaction. Tetrahedron 2011, 67(38), 7379 - 7385, 10.1016/j.tet.2011.07.040 .
.
Budesinsky, Milos;
Rosenberg, Ivan;
Protivinska, Eva;
Collinsova, Michaela;
Jiracek, Jiri;
Netusilova, Hana;
Garrow, Timothy A., S-alkylated homocysteine derivatives: New inhibitors of human betaine-homocysteine S-methyltransferase. Journal of Medicinal Chemistry 2006, 49(13), 3982 - 3989, 10.1021/jm050885v .
.
Patents
Antonin, Holy;
Jan M. R., Balzarini;
Erik D. A., De Clercq, Novel compounds and methods for therapy, US2003/109499, 2003.