Molecular Formula: C7H7ClO2S
Molecular weight: 190.64728
InChi: InChI=1S/C7H7ClO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3
InChi Key: YYROPELSRYBVMQ-UHFFFAOYSA-N
SMILES: S(=O)(=O)(c1ccc(cc1)C)Cl
Chemical Name
(4-methylphenyl)sulfonyl chloride
4-methyl-benzenesulfonyl chloride
4-methylbenzene-1-sulfonyl chloride
4-methylbenzene-sulfonyl chloride
4-methylphenylsulfonic acid chloride
benzenesulfonyl chloride, 4-methyl-
p-toluenesulfonyl chloride
(4-methylphenyl)sulfonyl chloride
4-methyl-benzenesulfonyl chloride
4-methylbenzene-1-sulfonyl chloride
4-methylbenzene-sulfonyl chloride
4-methylphenylsulfonic acid chloride
benzenesulfonyl chloride, 4-methyl-
p-toluenesulfonyl chloride

Cisarova, Ivana
Bures, Filip
Kulhanek, Jiri
Pytela, Oldrich
Ludwig, Miroslav
Ruzicka, Ales
Tydlitat, Jiri
Mloston, Grzegorz
Hrdina, Radim
Cerny, Miloslav
Dolezalova, Jitka
Trnka, Tomas
Budesinsky, Milos
Cerny, Ivan
Krecmerova, Marcela
Holy, Antonin
Elbert, Tomas
Jindrich, Jindrich
Kroutil, Jiri
Karban, Jindrich
Trtek, Tomas
Polakova, Jana
Hamernikova, Michaela
Dracinsky, Martin
Kocovsky, Pavel
Parik, Patrik
Dvorakova, Hana
Hodacova, Jana
Stibor, Ivan
Jansa, Petr
Zavada, Jiri
Hocek, Michal
Votruba, Ivan
Potacek, Milan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Hockova, Dana
Pohl, Radek
Klepetarova, Blanka
Otmar, Miroslav
Holy, Petr
Chadim, Martin
Garcia-Espana, Enrique
Soriano, Conxa
Valterova, Irena
Verdejo, Begona
Basallote, Manuel Garcia
Ferrer, Armando
Manez, Maria Angeles
Hernandez, Juan Carlos
Llinares, Jose Miguel
Rosenberg, Ivan
Hrebabecky, Hubert
Clercq, Erik de
Merta, Ales
Kohoutova, Jitka
Spassova, Maria K.
Liboska, Radek
Alexander, Petr
Cvorakova, Hana
Jurikova, Kristina
Smrckova, Svatava
Votavova, Hana
Janeba, Zlatko
Tocik, Zdenek
Meszarosova, Katerina
Naesens, Lieve
Pomeisl, Karel
Vrbovska, Silvie
Piskala, Alois
Neyts, Johan
Vrbkova, Silvie
Keough, Dianne T.
Guddat, Luke W.
Tichy, Tomas
Jersey, John de
Baszczynski, Ondrej
Rejman, Dominik
Antonin, Holy
Jan Marie Rene, Balzarini
Hana, Dvorakova
Erik Desire Alice, De Clercq
Belokon, Yuri N.
Bespalova, Natalia B.
Churkina, Tatiana D.
Ezernitskaya, Marina G.
Harutyunyan, Syuzanna R.
Kagan, Henri B.
Kochetkov, Konstantin A.
Larionov, Oleg V.
Lyssenko, Konstantin A.
North, Michael
Polasek, Miroslav
Peregudov, Alexander S.
Prisyazhnyuk, Vladimir V.
Vyskocil, Stepan
Francom, Paula
Robins, Morris J.
Michl, Josef
Vecera, Miroslav
Paleta, Oldrich
Kvicala, Jaroslav
Pelter, Andrew
Plocar, Jakub
Vlasakova, Ruzena
Sykora, Jan
Lhotak, Pavel
Budka, Jan
Michlova, Veronika
Kalfus, Karel
Stverka, Pavel
Mansfeld, Martin
Machara, Ales
Werner, Lukas
Hudlicky, Tomas
Adams, David R.
Sullivan, Bradford
Carrera, Ignacio
Moser, Michael
Andraos, John
Mazal, Ctibor
Rothova, Vera
Jonas, Jaroslav
Kaszynski, Piotr
Radziszewski, Juliusz G.
Balaji
Littmann, Dieter
Hess Jr.
Man, Stanislav
Navratilova, Hana
Kriz, Zdenek
Buchlovic, Marian
V
ecera, Miroslav
Endova, Magdalena
Paces, Ondrej
Kosiova, Ivana
Simak, Ondrej
Svatos, Ales
Kocian, Oldrich
Hovorka, Oldrich
Urbanova, Klara
Bures, Filip
Kulhanek, Jiri
Pytela, Oldrich
Ludwig, Miroslav
Ruzicka, Ales
Tydlitat, Jiri
Mloston, Grzegorz
Hrdina, Radim
Cerny, Miloslav
Dolezalova, Jitka
Trnka, Tomas
Budesinsky, Milos
Cerny, Ivan
Krecmerova, Marcela
Holy, Antonin
Elbert, Tomas
Jindrich, Jindrich
Kroutil, Jiri
Karban, Jindrich
Trtek, Tomas
Polakova, Jana
Hamernikova, Michaela
Dracinsky, Martin
Kocovsky, Pavel
Parik, Patrik
Dvorakova, Hana
Hodacova, Jana
Stibor, Ivan
Jansa, Petr
Zavada, Jiri
Hocek, Michal
Votruba, Ivan
Potacek, Milan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Hockova, Dana
Pohl, Radek
Klepetarova, Blanka
Otmar, Miroslav
Holy, Petr
Chadim, Martin
Garcia-Espana, Enrique
Soriano, Conxa
Valterova, Irena
Verdejo, Begona
Basallote, Manuel Garcia
Ferrer, Armando
Manez, Maria Angeles
Hernandez, Juan Carlos
Llinares, Jose Miguel
Rosenberg, Ivan
Hrebabecky, Hubert
Clercq, Erik de
Merta, Ales
Kohoutova, Jitka
Spassova, Maria K.
Liboska, Radek
Alexander, Petr
Cvorakova, Hana
Jurikova, Kristina
Smrckova, Svatava
Votavova, Hana
Janeba, Zlatko
Tocik, Zdenek
Meszarosova, Katerina
Naesens, Lieve
Pomeisl, Karel
Vrbovska, Silvie
Piskala, Alois
Neyts, Johan
Vrbkova, Silvie
Keough, Dianne T.
Guddat, Luke W.
Tichy, Tomas
Jersey, John de
Baszczynski, Ondrej
Rejman, Dominik
Antonin, Holy
Jan Marie Rene, Balzarini
Hana, Dvorakova
Erik Desire Alice, De Clercq
Belokon, Yuri N.
Bespalova, Natalia B.
Churkina, Tatiana D.
Ezernitskaya, Marina G.
Harutyunyan, Syuzanna R.
Kagan, Henri B.
Kochetkov, Konstantin A.
Larionov, Oleg V.
Lyssenko, Konstantin A.
North, Michael
Polasek, Miroslav
Peregudov, Alexander S.
Prisyazhnyuk, Vladimir V.
Vyskocil, Stepan
Francom, Paula
Robins, Morris J.
Michl, Josef
Vecera, Miroslav
Paleta, Oldrich
Kvicala, Jaroslav
Pelter, Andrew
Plocar, Jakub
Vlasakova, Ruzena
Sykora, Jan
Lhotak, Pavel
Budka, Jan
Michlova, Veronika
Kalfus, Karel
Stverka, Pavel
Mansfeld, Martin
Machara, Ales
Werner, Lukas
Hudlicky, Tomas
Adams, David R.
Sullivan, Bradford
Carrera, Ignacio
Moser, Michael
Andraos, John
Mazal, Ctibor
Rothova, Vera
Jonas, Jaroslav
Kaszynski, Piotr
Radziszewski, Juliusz G.
Balaji
Littmann, Dieter
Hess Jr.
Man, Stanislav
Navratilova, Hana
Kriz, Zdenek
Buchlovic, Marian
V
ecera, Miroslav
Endova, Magdalena
Paces, Ondrej
Kosiova, Ivana
Simak, Ondrej
Svatos, Ales
Kocian, Oldrich
Hovorka, Oldrich
Urbanova, Klara

Bures, Filip;
Kulhanek, Jiri;
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Cisarova, Ivana;
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Holy, Antonin;
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De Clercq, Erik, Synthesis and antiviral activity of acyclic nucleotide analogues derived from 6-(aminomethyl)purines and purine-6-carboxamidines. Collect. Czech. Chem. Commun. 1996, 61(10), 1525 - 1537, 10.1135/cccc19961525
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Hodacova, Jana;
Chadim, Martin;
Garcia-Espana, Enrique;
Soriano, Conxa;
Verdejo, Begona;
Basallote, Manuel Garcia;
Ferrer, Armando;
Manez, Maria Angeles;
Hernandez, Juan Carlos;
Llinares, Jose Miguel, Equilibrium and kinetic properties of Cu cyclophane complexes: The effect of changes in the macrocyclic cavity caused by changes in the substitution at the aromatic ring. European Journal of Inorganic Chemistry 2008(9), 1497 - 1507, 10.1002/ejic.200701109
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Krecmerova, Marcela;
Holy, Antonin;
Hrebabecky, Hubert, SYNTHESIS OF 5'-O-PHOSPHONOMETHYL DERIVATIVES OF PYRIMIDINE 2'-DEOXYNUCLEOSIDES. Collect. Czech. Chem. Commun. 1990, 55(10), 2521 - 2536.
Holy, Antonin, PREPARATION AND SYNTHETIC UTILIZATION OF 3-(ADENIN-9-YL)-2-HYDROXYALKANOIC ACIDS AND THEIR DERIVATIVES. Collect. Czech. Chem. Commun. 1984, 49(9), 2148 - 2166.
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Rosenberg, Ivan, SYNTHESIS OF 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE AND RELATED COMPOUNDS. Collect. Czech. Chem. Commun. 1987, 52(11), 2801 - 2809.
Holy, Antonin;
Rosenberg, Ivan, PREPARATION OF 5'-O-PHOSPHONYLMETHYL ANALOGUES OF NUCLEOSIDE-5'-PHOSPHATES, 5'-DIPHOSPHATES AND 5'-TRIPHOSPHATES. Collect. Czech. Chem. Commun. 1982, 47(12), 3447 - 3463.
Holy, Antonin;
Votruba, Ivan;
Merta, Ales;
Kohoutova, Jitka, 9-(AMINOALKYL)-8-HYDROXYADENINES: PREPARATION, MECHANISM OF FORMATION AND USE IN AFFINITY CHROMATOGRAPHY OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. Collect. Czech. Chem. Commun. 1986, 51(2), 459 - 477.
Holy, Antonin, SYNTHESIS OF EIGHT STEREOISOMERIC 5-(ADENIN-9-YL)-2,3,4-TRIHYDROXYPENTANOIC ACIDS. Collect. Czech. Chem. Commun. 1982, 47(11), 2969 - 2988.
Holy, Antonin, PREPARATION OF ISOMERIC 3-AMINOPROPYLAMINO DERIVATIVES OF 9-(RS)-(2,3-DIHYDROXYPROPYL)ADENINE. Collect. Czech. Chem. Commun. 1983, 48(7), 1910 - 1921.
Holy, Antonin, BRANCHED-CHAIN DERIVATIVES OF ACYCLIC ADENOSINE ANALOGS: ALKYL AND HYDROXYMETHYL DERIVATIVES OF S-ADENOSYL-L-HOMOCYSTEINASE INHIBITORS SUBSTITUTED AT THE 2- AND 3-POSITION OF THE SIDE CHAIN. Collect. Czech. Chem. Commun. 1989, 54(1), 248 - 265.
Holy, Antonin, SYNTHESIS OF 3-AMINO- AND 3-AZIDOANALOGS OF 9-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROPYL)ADENINE (HPMPA). Collect. Czech. Chem. Commun. 1989, 54(2), 446 - 454.
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Masojidkova, Milena;
Spassova, Maria K., RIBONUCLEOSIDES OF 3-AMINO- AND 3,5-DIAMINOPYRAZOLE-4-CARBOXYLIC ACID AND THEIR OPEN-CHAIR ANALOGUES: SYNTHESIS AND REACTIONS. Collect. Czech. Chem. Commun. 1986, 51(7), 1512 - 1531.
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Jindrich, Jindrich;
Dvorakova, Hana, SYNTHESIS OF ISOMERIC N-(3-FLUORO-2-HYDROXYPROPYL) AND N-(2-FLUORO-3-HYDROXYPROPYL) DERIVATIVES OF PURINE AND PYRIMIDINE BASES. Collect. Czech. Chem. Commun. 1992, 57(7), 1466 - 1482, 10.1135/cccc19921466
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Holy, Antonin, SYNTHESES OF ENANTIOMERIC N-(3-HYDROXY-2-PHOSPHONOMETHOXYPROPYL)DERIVATIVES OF PURINE AND PYRIMIDINE BASES. Collect. Czech. Chem. Commun. 1993, 58(3), 649 - 674, 10.1135/cccc19930649
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Holy, Antonin;
Jindrich, Jindrich;
Dvorakova, Hana, SYNTHESIS OF N-(3-FLUORO-2-PHOSPHONOMETHOXYPROPYL) (FPMP) DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1993, 58(7), 1645 - 1667, 10.1135/cccc19931645
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Holy, Antonin;
Masojidkova, Milena;
Otmar, Miroslav;
Rosenberg, Ivan, <5-(ADENIN-9-YL)-5-DEOXYPENTOFURANOSYL>PHOSPHONATES - A NOVEL TYPE NUCLEOTIDE ANALOGS RELATED TO HPMPA. I. DERIVATIVES WITH L-arabino, D-arabino, 2-DEOXY-L-erythro AND 2-DEOXY-L-threo CONFIGURATION. Collect. Czech. Chem. Commun. 1993, 58(9), 2159 - 2179, 10.1135/cccc19932159
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Holy, Antonin;
Masojidkova, Milena;
Otmar, Miroslav;
Rosenberg, Ivan, <5-(ADENIN-9-YL)-5-DEOXY-L-PENTOFURANOSYL>PHOSPHONATES - A NOVEL TYPE OF NUCLEOTIDE ANALOGS RELATED TO HPMPA. II. SYNTHESIS OF L-ribo and L-xylo CONFIGURATED DERIVATIVES BY RECYCLIZATION OF DIETHYL (5-RS)-<1,2-O-ISOPROPYLIDENE-5-O-METHANESULFONYL-D-PENTOFURANOS-5-C-YL>PHOSPHONATES .... Collect. Czech. Chem. Commun. 1993, 58(9), 2180 - 2196, 10.1135/cccc19932180
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Masojidkova, Milena;
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Rosenberg, Ivan;
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Holy, Antonin;
Jurikova, Kristina;
Smrckova, Svatava, SYNTHESIS OF BASE-MODIFIED "ABBREVIATED" NAD ANALOGUES. Collect. Czech. Chem. Commun. 1995, 60(2), 237 - 250, 10.1135/cccc19950237
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Holy, Antonin;
Masojidkova, Milena, SYNTHESIS OF ENANTIOMERIC N-(2-PHOSPHONOMETHOXYPROPYL) DERIVATIVES OF PURINE AND PYRIMIDINE BASES. I. THE STEPWISE APPROACH. Collect. Czech. Chem. Commun. 1995, 60(7), 1196 - 1212, 10.1135/cccc19951196
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Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena, SYNTHESIS OF ENANTIOMERIC N-(2-PHOSPHONOMETHOXYPROPYL)DERIVATIVES OF PURINE AND PYRIMIDINE BASES. II. THE SYNTHON APPROACH. Collect. Czech. Chem. Commun. 1995, 60(8), 1390 - 1409, 10.1135/cccc19951390
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Holy, Antonin;
Hockova, Dana;
Votavova, Hana, Synthesis and Chiroptical Properties of Some Abbreviated NAD Analogues. Tetrahedron Asymmetry 1995, 6(9), 2375 - 2384, 10.1016/0957-4166(95)00315-G
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Holy, Antonin;
Masojidkova, Milena;
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Holy, Antonin;
Balzarini, Jan;
Hrebabecky, Hubert, Preparation of chloro and sulfanyl derivatives of 1-(2-deoxy-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)uracil. Collect. Czech. Chem. Commun. 1997, 62(7), 1114 - 1127.
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Hrebabecky, Hubert, Synthesis of carba analogues of 2′-deoxy-4′-C-(hydroxymethyl)nucleosides. Collect. Czech. Chem. Commun. 1999, 64(9), 1485 - 1496.
Holy, Antonin;
Hrebabecky, Hubert, Synthesis of carbocyclic 4′-C-hydroxymethyl analogues of azidodeoxythymidine, deoxythymidine, deoxydidehydrothymidine and thymidine carba analogue with fused oxetane ring. Collect. Czech. Chem. Commun. 2000, 65(3), 395 - 406.
Holy, Antonin;
Masojidkova, Milena;
Meszarosova, Katerina, Synthesis of acyclic adenine 8,N-anhydronucleosides. Collect. Czech. Chem. Commun. 2000, 65(7), 1109 - 1125.
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Hrebabecky, Hubert, Synthesis of carba analogues of deoxy-4-C-(hydroxymethyl)-hexopyranoses, intermediates in the synthesis of carbocyclic nucleosides. Collect. Czech. Chem. Commun. 2001, 66(5), 785 - 798, 10.1135/cccc20010785
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Holy, Antonin;
Masojidkova, Milena;
Janeba, Zlatko, Synthesis of 8-amino-and N-substituted 8-aminoadenine derivatives of acyclic nucleoside and nucleotide analogs. Collect. Czech. Chem. Commun. 2001, 66(3), 517 - 532, 10.1135/cccc20010517
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Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana, 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy) ethoxy]pyrimidines-Acyclic Nucleoside Phosphonate Analogues with Antiviral Activity. Journal of Medicinal Chemistry 2003, 46(23), 5064 - 5073.
Holy, Antonin;
Masojidkova, Milena;
Pohl, Radek;
Vrbovska, Silvie, Bifunctional acyclic nucleoside phosphonates. 1. Symmetrical 1,3-bis[(phosphonomethoxy)propan-2-yl] derivatives of purines and pyrimidines. Collect. Czech. Chem. Commun. 2006, 71(4), 543 - 566, 10.1135/cccc20060543
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Holy, Antonin;
Votruba, Ivan;
Pohl, Radek;
Pomeisl, Karel, Syntheses of base and side-chain modified pyrimidine 1-[2- (phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma. Collect. Czech. Chem. Commun. 2006, 71(4), 595 - 624, 10.1135/cccc20060595
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Holy, Antonin;
Dracinsky, Martin;
Vrbkova, Silvie, Synthesis of phosphonomethoxyethyl or 1,3-bis(phosphonomethoxy)propan-2-yl lipophilic esters of acyclic nucleoside phosphonates. Tetrahedron 2007, 63(46), 11391 - 11398, 10.1016/j.tet.2007.08.081
.

Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena, Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position. Bioorganic and Medicinal Chemistry 2010, 18(1), 387 - 395, 10.1016/j.bmc.2009.10.044
.

Holy, Antonin;
Masojidkova, Milena;
Janeba, Zlatko, Alternative synthesis of 9-{3-[(diisopropoxyphosphoryl)-methoxy]-2- hydroxypropyl}adenine and its free phosphonates substituted at the c-8 position of purine base. Collect. Czech. Chem. Commun. 2010, 75(3), 371 - 381, 10.1135/cccc2009569
.

Holy, Antonin;
Masojidkova, Milena;
Hockova, Dana;
Keough, Dianne T.;
Guddat, Luke W.;
Jersey, John de, Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorganic and Medicinal Chemistry 2009, 17(17), 6218 - 6232, 10.1016/j.bmc.2009.07.044
.

Holy, Antonin;
Dracinsky, Martin;
Jansa, Petr;
Votruba, Ivan;
Balzarini, Jan;
Klepetarova, Blanka;
Clercq, Erik de;
Janeba, Zlatko;
Baszczynski, Ondrej, Synthesis and antiviral activity of N-[3-fluoro-2- (phosphonomethoxy)propyl] analogues derived from N-substituted adenines and 2,6-diaminopurines. Bioorganic and Medicinal Chemistry 2011, 19(7), 2114 - 2124, 10.1016/j.bmc.2011.02.050
.

Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Tichy, Tomas, New prodrugs of Adefovir and Cidofovir. Bioorganic and Medicinal Chemistry 2011, 19(11), 3527 - 3539, 10.1016/j.bmc.2011.04.016
.

Cisarova, Ivana;
Hrdina, Radim;
Kocovsky, Pavel;
Belokon, Yuri N.;
Bespalova, Natalia B.;
Churkina, Tatiana D.;
Ezernitskaya, Marina G.;
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