Molecular Formula: C5H6N6
Molecular weight: 150.14134
InChi: InChI=1S/C5H6N6/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H5,6,7,8,9,10,11)
InChi Key: MSSXOMSJDRHRMC-UHFFFAOYSA-N
SMILES: c12c(c(nc(n1)N)N)nc[nH]2
Chemical Name
2,6-diamino purine
2,6-diamino-9H-purine
2,6-Diaminopurine
2-aminoadenine
9H-2,6-diaminopurine
diaminopurine
HDap
2,6-diamino purine
2,6-diamino-9H-purine
2,6-Diaminopurine
2-aminoadenine
9H-2,6-diaminopurine
diaminopurine
HDap
Authors of compound
Budesinsky, Milos
Krecmerova, Marcela
Holy, Antonin
et al.
Dracinsky, Martin
Dvorakova, Hana
Jansa, Petr
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Hockova, Dana
Pohl, Radek
Rosenberg, Ivan
Alexander, Petr
Spassova, Maria
Guenter, Jaroslav
Janeba, Zlatko
Horejsi, Katerina
Neyts, Johan
Kasicka, Vaclav
Brehova, Petra
Sedlacek, Ondrej
Stepan, George
Sazelova, Petra
Auwerx, Joeri
Kiss, Eleonora
Goris, Nesya
Krecmerova, Marcela
Holy, Antonin
et al.
Dracinsky, Martin
Dvorakova, Hana
Jansa, Petr
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Hockova, Dana
Pohl, Radek
Rosenberg, Ivan
Alexander, Petr
Spassova, Maria
Guenter, Jaroslav
Janeba, Zlatko
Horejsi, Katerina
Neyts, Johan
Kasicka, Vaclav
Brehova, Petra
Sedlacek, Ondrej
Stepan, George
Sazelova, Petra
Auwerx, Joeri
Kiss, Eleonora
Goris, Nesya
Articles
Holy, Antonin;
Dvorakova, Hana;
Rosenberg, Ivan, SYNTHESIS OF N-(2-(2-PHOSPHONYLETHOXY)ETHYL) DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1990, 55(3), 809 - 818.
Holy, Antonin, PREPARATION AND SYNTHETIC UTILIZATION OF 3-(ADENIN-9-YL)-2-HYDROXYALKANOIC ACIDS AND THEIR DERIVATIVES. Collect. Czech. Chem. Commun. 1984, 49(9), 2148 - 2166.
Holy, Antonin;
Dvorakova, Hana;
Rosenberg, Ivan, SYNTHESIS OF N-(2-PHOSPHONYLMETHOXYETHYL) DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1989, 54(8), 2190 - 2210.
Holy, Antonin;
Dvorakova, Hana;
Rosenberg, Ivan, SYNTHESIS OF (3-HYDROXY-2-PHOSPHONYLMETHOXYPROPYL) DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1989, 54(9), 2470 - 2501.
Holy, Antonin, SYNTHESES OF ENANTIOMERIC N-(3-HYDROXY-2-PHOSPHONOMETHOXYPROPYL)DERIVATIVES OF PURINE AND PYRIMIDINE BASES. Collect. Czech. Chem. Commun. 1993, 58(3), 649 - 674, 10.1135/cccc19930649 
.
.
Holy, Antonin;
Alexander, Petr, GENERAL METHOD OF PREPARATION OF N-<(S)-(3-HYDROXY-2-PHOSPHONOMETHOXYPROPYL)> DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1993, 58, 1151 - 1163, 10.1135/cccc19931151 .
.
Budesinsky, Milos;
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Spassova, Maria, SYNTHEIS OF N-(3-AZIDO-2-HYDROXYPROPYL), N-(3-PHTHALIMIDO-2-HYDROXYPROPYL) AND N-(3-AMINO-2-HYDROXYPROPYL)DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1994, 59(5), 1153 - 1174, 10.1135/cccc19941153 .
.
Holy, Antonin;
et al.;
Dvorakova, Hana;
Votruba, Ivan;
Hockova, Dana;
Guenter, Jaroslav, SYNTHESIS OF 2-DEOXY-β-D-RIBONUCLEOSIDES AND2,3-DIDEOXY.β-D-PENTOFURANOSIDES ON IMMOBILIZED BACTERIAL CELLS. Collect. Czech. Chem. Commun. 1994, 59(10), 2303 - 2330, 10.1135/cccc19942303 .
.
Holy, Antonin;
Masojidkova, Milena, SYNTHESIS OF ENANTIOMERIC N-(2-PHOSPHONOMETHOXYPROPYL) DERIVATIVES OF PURINE AND PYRIMIDINE BASES. I. THE STEPWISE APPROACH. Collect. Czech. Chem. Commun. 1995, 60(7), 1196 - 1212, 10.1135/cccc19951196 .
.
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena, SYNTHESIS OF ENANTIOMERIC N-(2-PHOSPHONOMETHOXYPROPYL)DERIVATIVES OF PURINE AND PYRIMIDINE BASES. II. THE SYNTHON APPROACH. Collect. Czech. Chem. Commun. 1995, 60(8), 1390 - 1409, 10.1135/cccc19951390 .
.
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik, Synthesis of 2'-aminomethyl derivatives of N-(2- (phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents. Journal of Medicinal Chemistry 1996, 39(17), 3263 - 3268, 10.1021/jm9601314 .
.
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Guenter, Jaroslav, Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. Journal of Medicinal Chemistry 1999, 42(12), 2064 - 2086, 10.1021/jm9811256 .
.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena, Synthesis of N- and N-[2-hydroxy-3- (phosphonomethoxy)-propyl] derivatives of N-substituted adenines, 2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 2004, 69(10), 1889 - 1913, 10.1135/cccc20041889 .
.
Holy, Antonin;
Pohl, Radek;
Horejsi, Katerina, Tricyclic purine analogs derived from 2-amino-6-chloropurine and 2,6-diaminopurine and their methylated quaternary salts. Collect. Czech. Chem. Commun. 2006, 71(1), 77 - 90, 10.1135/cccc20060077 .
.
Holy, Antonin;
Pohl, Radek;
Janeba, Zlatko;
Brehova, Petra;
Sedlacek, Ondrej, The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy) ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions. Canadian Journal of Chemistry 2011, 89(4), 488 - 498, 10.1139/V11-001 .
.
Krecmerova, Marcela;
Dracinsky, Martin;
Jansa, Petr;
Janeba, Zlatko;
Neyts, Johan;
Kasicka, Vaclav;
Stepan, George;
Sazelova, Petra;
Auwerx, Joeri;
Kiss, Eleonora;
Goris, Nesya, 9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: Optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro. Bioorganic and Medicinal Chemistry 2013, 21(5), 1199 - 1208, 10.1016/j.bmc.2012.12.044 .
.