Molecular Formula: C9H14N5O5P
Molecular weight: 303.211721
InChi: InChI=1S/C9H14N5O5P/c10-9-12-7-6(8(15)13-9)11-5-14(7)1-2-19-3-4-20(16,17)18/h5H,1-4H2,(H2,16,17,18)(H3,10,12,13,15)
InChi Key: KDWYBFCNTYIRFX-UHFFFAOYSA-N
SMILES: c12c(n(cn2)CCOCCP(=O)(O)O)nc([nH]c1=O)N
Chemical Name
9-(2-(2-phosphonylethoxy)ethyl)guanine
9-[(2-phosphonoethoxy)ethyl]guanine
9-[2-(2-phosphonoethoxy)ethyl]guanine
9-[2-(2-phosphonylethoxy)ethyl]guanine
9-[2-(phosphonoethoxy)ethyl]guanine
9-(2-(2-phosphonylethoxy)ethyl)guanine
9-[(2-phosphonoethoxy)ethyl]guanine
9-[2-(2-phosphonoethoxy)ethyl]guanine
9-[2-(2-phosphonylethoxy)ethyl]guanine
9-[2-(phosphonoethoxy)ethyl]guanine
Authors of compound
Krecmerova, Marcela
Holy, Antonin
Dracinsky, Martin
Dvorakova, Hana
Cesnek, Michal
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
Hockova, Dana
Slavetinska, Lenka
Cihlar, Tomas
Tloustova, Eva
Rosenberg, Ivan
Janeba, Zlatko
Naesens, Lieve
Schinkmanova, Marketa
Vrbkova, Silvie
Shibata, Riri
Han, Bin
Liu, Xiaohong
Keough, Dianne T.
De Jersey, John
Guddat, Luke W.
Tichy, Tomas
Jersey, John de
Baszczynski, Ondrej
Spacek, Petr
Wang, Tzu-Hsuan
Edstein, Michael D.
Chavchich, Marina
Holy, Antonin
Dracinsky, Martin
Dvorakova, Hana
Cesnek, Michal
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
Hockova, Dana
Slavetinska, Lenka
Cihlar, Tomas
Tloustova, Eva
Rosenberg, Ivan
Janeba, Zlatko
Naesens, Lieve
Schinkmanova, Marketa
Vrbkova, Silvie
Shibata, Riri
Han, Bin
Liu, Xiaohong
Keough, Dianne T.
De Jersey, John
Guddat, Luke W.
Tichy, Tomas
Jersey, John de
Baszczynski, Ondrej
Spacek, Petr
Wang, Tzu-Hsuan
Edstein, Michael D.
Chavchich, Marina
Articles
Holy, Antonin;
Dvorakova, Hana;
Rosenberg, Ivan, SYNTHESIS OF N-(2-(2-PHOSPHONYLETHOXY)ETHYL) DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1990, 55(3), 809 - 818.
Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Tloustova, Eva, Synthesis and cytostatic activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N-substituted adenines, 2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 2001, 66(10), 1545 - 1592.
Holy, Antonin;
Votruba, Ivan;
Cihlar, Tomas;
Schinkmanova, Marketa;
Shibata, Riri;
Han, Bin;
Liu, Xiaohong, Human N-methyl-AMP/dAMP aminohydrolase (abacavir 5-monophosphate deaminase) is capable of metabolizing N-substituted purine acyclic nucleoside phosphonates. Collect. Czech. Chem. Commun. 2008, 73(2), 275 - 291, 10.1135/cccc20080275 
.
.
Holy, Antonin;
Masojidkova, Milena;
Hockova, Dana;
Keough, Dianne T.;
Guddat, Luke W.;
Jersey, John de, Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorganic and Medicinal Chemistry 2009, 17(17), 6218 - 6232, 10.1016/j.bmc.2009.07.044 .
.
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
Hockova, Dana, Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity. Bioorganic and Medicinal Chemistry 2011, 19(15), 4445 - 4453, 10.1016/j.bmc.2011.06.045 .
.
Holy, Antonin;
Dracinsky, Martin;
Cesnek, Michal;
Hockova, Dana;
Keough, Dianne T.;
Guddat, Luke W.;
Jersey, John de;
Baszczynski, Ondrej, Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorganic and Medicinal Chemistry 2012, 20(2), 1076 - 1089, 10.1016/j.bmc.2011.11.034 .
.
Krecmerova, Marcela;
Holy, Antonin;
Dracinsky, Martin;
Hockova, Dana;
Keough, Dianne T.;
Guddat, Luke W., Synthesis of purine N-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorganic and Medicinal Chemistry 2012, 20(3), 1222 - 1230, 10.1016/j.bmc.2011.12.034 .
.
Hockova, Dana;
Janeba, Zlatko;
Keough, Dianne T.;
De Jersey, John;
Guddat, Luke W.;
Wang, Tzu-Hsuan, Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry 2012, 55(13), 6209 - 6223, 10.1021/jm300662d .
.
Hockova, Dana;
Slavetinska, Lenka;
Janeba, Zlatko;
Naesens, Lieve;
Vrbkova, Silvie;
Keough, Dianne T.;
De Jersey, John;
Guddat, Luke W.;
Tichy, Tomas;
Spacek, Petr;
Wang, Tzu-Hsuan;
Edstein, Michael D.;
Chavchich, Marina, Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. Journal of Medicinal Chemistry 2013, 56(6), 2513 - 2526, 10.1021/jm301893b .
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