Detail of compound @ czechem

Molecular Formula: C₇H₁₂N₃O₅P

Molecular weight: 249.161041

InChi: InChI=1S/C7H12N3O5P/c8-6-1-2-10(7(11)9-6)3-4-15-5-16(12,13)14/h1-2H,3-5H2,(H2,8,9,11)(H2,12,13,14)

InChi Key: XXUKNWCJFNYLDP-UHFFFAOYSA-N

SMILES: c1(=O)n(ccc(n1)N)CCOCP(=O)(O)O

Chemical Name
1-(2-Phosphonylmethoxyethyl)cytosine
1-[2-(Phosphonomethoxy)ethyl]cytosine
PMEC

External Links
PubChem

Authors of compound

Holy, Antonin
Dracinsky, Martin
Dvorakova, Hana
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Cihlar, Tomas
Rosenberg, Ivan
Sigel, Helmut
Guenter, Jaroslav
Blindauer, Claudia A.
Olsanska, Lenka
Chalupova, Sarka
Vrbkova, Silvie

Articles

Holy, Antonin; Dvorakova, Hana; Rosenberg, Ivan, SYNTHESIS OF N-(2-PHOSPHONYLMETHOXYETHYL) DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1989, 54(8), 2190 - 2210.

Holy, Antonin; Votruba, Ivan; Cihlar, Tomas; Olsanska, Lenka, Transport of adefovir (PMEA) in human T-lymphoblastoid cells. Collect. Czech. Chem. Commun. 1997, 62(5), 821 - 828.

Holy, Antonin; Dvorakova, Hana; Masojidkova, Milena; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik; Guenter, Jaroslav, Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. Journal of Medicinal Chemistry 1999, 42(12), 2064 - 2086, 10.1021/jm9811256

Holy, Antonin; Sigel, Helmut; Blindauer, Claudia A., Metal ion-binding properties of the nucleotide analogue 1-[2-(phosphonomethoxy)ethyl]cytosine (PMEC) in aqueous solution. Collect. Czech. Chem. Commun. 1999, 64(4), 613 - 632.

Holy, Antonin; Masojidkova, Milena; Chalupova, Sarka, Synthesis of N-substituted derivatives of 1-[2- (phosphonomethoxy)ethyl]cytosine and its diisopropyl ester as a model reaction for the synthesis of N-substituted derivatives of cidofovir. Collect. Czech. Chem. Commun. 2005, 70(12), 2066 - 2074, 10.1135/cccc20052066

Holy, Antonin; Dracinsky, Martin; Vrbkova, Silvie, Synthesis of phosphonomethoxyethyl or 1,3-bis(phosphonomethoxy)propan-2-yl lipophilic esters of acyclic nucleoside phosphonates. Tetrahedron 2007, 63(46), 11391 - 11398, 10.1016/j.tet.2007.08.081