Molecular Formula: C8H13N6O4P
Molecular weight: 288.200381
InChi: InChI=1S/C8H13N6O4P/c9-6-5-7(13-8(10)12-6)14(3-11-5)1-2-18-4-19(15,16)17/h3H,1-2,4H2,(H2,15,16,17)(H4,9,10,12,13)
InChi Key: XHXFQGAZAVKMFF-UHFFFAOYSA-N
SMILES: c12c(c(nc(n2)N)N)ncn1CCOCP(=O)(O)O
Chemical Name
((2-(2,6-diamino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid
2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine
9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine
PMEDAP
((2-(2,6-diamino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid
2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine
9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine
PMEDAP
Authors of compound
Krecmerova, Marcela
Holy, Antonin
Elbert, Tomas
Dracinsky, Martin
Dvorakova, Hana
Jansa, Petr
Cesnek, Michal
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Pohl, Radek
Tloust'Ova, Eva
Rosenberg, Ivan
Clercq, Erik de
Horska, Kvetoslava
Guenter, Jaroslav
Janeba, Zlatko
Zidek, Zdenek
Krejcova, Romana
Hajek, Miroslav
Keith, Kathy A.
Hitchcock, Michael J. M.
Lee, William A.
Kern, Earl R.
Kmonickova, Eva
Matulova, Nadezda
Potmesil, Petr
Kmoniekova, Eva
Horejsi, Katerina
Horska, Kvtoslava
Duraffour, Sophie
Van Den Oord, Joost
De Vos, Rita
Crance, Jean-Marc
Garin, Daniel
Solinova, Veronika
Koval, Dusan
Kasicka, Vaclav
Pechar, Michal
Braunova, Alena
Subr, Vladimir
Ulbrich, Karel
Brehova, Petra
Baszczynski, Ondrej
Prochazkova, Eliska
Holy, Antonin
Elbert, Tomas
Dracinsky, Martin
Dvorakova, Hana
Jansa, Petr
Cesnek, Michal
Votruba, Ivan
Masojidkova, Milena
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
Pohl, Radek
Tloust'Ova, Eva
Rosenberg, Ivan
Clercq, Erik de
Horska, Kvetoslava
Guenter, Jaroslav
Janeba, Zlatko
Zidek, Zdenek
Krejcova, Romana
Hajek, Miroslav
Keith, Kathy A.
Hitchcock, Michael J. M.
Lee, William A.
Kern, Earl R.
Kmonickova, Eva
Matulova, Nadezda
Potmesil, Petr
Kmoniekova, Eva
Horejsi, Katerina
Horska, Kvtoslava
Duraffour, Sophie
Van Den Oord, Joost
De Vos, Rita
Crance, Jean-Marc
Garin, Daniel
Solinova, Veronika
Koval, Dusan
Kasicka, Vaclav
Pechar, Michal
Braunova, Alena
Subr, Vladimir
Ulbrich, Karel
Brehova, Petra
Baszczynski, Ondrej
Prochazkova, Eliska
Articles
Holy, Antonin;
Dvorakova, Hana;
Rosenberg, Ivan, SYNTHESIS OF N-(2-PHOSPHONYLMETHOXYETHYL) DERIVATIVES OF HETEROCYCLIC BASES. Collect. Czech. Chem. Commun. 1989, 54(8), 2190 - 2210.
Holy, Antonin;
Votruba, Ivan;
Zidek, Zdenek, Inhibition of Murine Lymphocyte Proliferation by N-Substituted Acyclic Purine Nucleoside Phosphonates. Collect. Czech. Chem. Commun. 1996, 61, S182 - S187.
Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Guenter, Jaroslav, Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. Journal of Medicinal Chemistry 1999, 42(12), 2064 - 2086, 10.1021/jm9811256 
.
.
Holy, Antonin;
Votruba, Ivan;
Horska, Kvetoslava;
Krejcova, Romana, Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells. Collect. Czech. Chem. Commun. 2000, 65(10), 1653 - 1668.
Holy, Antonin;
Keith, Kathy A.;
Hitchcock, Michael J. M.;
Lee, William A.;
Kern, Earl R., Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication. Antimicrobial Agents and Chemotherapy 2003, 47(7), 2193 - 2198, 10.1128/AAC.47.7.2193-2198.2003 .
.
Holy, Antonin;
Votruba, Ivan;
Tloust'Ova, Eva;
Hajek, Miroslav;
Matulova, Nadezda, Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates. Biochemical Pharmacology 2005, 70(6), 894 - 900, 10.1016/j.bcp.2005.06.007 .
.
Holy, Antonin;
Zidek, Zdenek;
Potmesil, Petr;
Kmoniekova, Eva, Immunobiological activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N-substituted adenines, and 2,6-diaminopurines. Eur. J. Pharmacol. 2003, 475(1-3), 149 - 159, 10.1016/S0014-2999(03)02110-1 .
.
Holy, Antonin;
Votruba, Ivan;
Krejcova, Romana;
Horska, Kvtoslava, Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes. Biochemical Pharmacology 2000, 60(12), 1907 - 1913, 10.1016/S0006-2952(00)00512-8 .
.
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
Pohl, Radek;
Clercq, Erik de;
Horejsi, Katerina, Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity. Bioorganic and Medicinal Chemistry 2006, 14(23), 8057 - 8065, 10.1016/j.bmc.2006.07.036 .
.
Krecmerova, Marcela;
Holy, Antonin;
Andrei, Graciela;
Snoeck, Robert;
De Clercq, Erik;
Duraffour, Sophie;
Van Den Oord, Joost;
De Vos, Rita;
Crance, Jean-Marc;
Garin, Daniel, Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. Antimicrobial Agents and Chemotherapy 2007, 51(12), 4410 - 4419, 10.1128/AAC.00838-07 .
.
Holy, Antonin;
Zidek, Zdenek;
Kmonickova, Eva, Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates. Eur. J. Pharmacol. 2007, 574(1), 77 - 84, 10.1016/j.ejphar.2007.07.024 .
.
Holy, Antonin;
Cesnek, Michal;
Masojidkova, Milena;
Solinova, Veronika;
Koval, Dusan;
Kasicka, Vaclav, Synthesis and properties of 2-guanidinopurines. Collect. Czech. Chem. Commun. 2006, 71(9), 1303 - 1319, 10.1135/cccc20061303 .
.
Holy, Antonin;
Pechar, Michal;
Braunova, Alena;
Subr, Vladimir;
Ulbrich, Karel, Polymemc conjugates of 9-[2-(phosphonomethoxy)ethyl]purine with potential antiviral and cytostatic activity. Collect. Czech. Chem. Commun. 2006, 71(8), 1211 - 1220, 10.1135/cccc20061211 .
.