Journal of Medicinal Chemistry
ISSN:
0022-2623
Articles
Holy, Antonin;
Dvorakova, Hana;
Hocek, Michal;
Votruba, Ivan, Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: Application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids. Journal of Medicinal Chemistry 2000, 43(9), 1817 - 1825, 10.1021/jm991167+ 
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Furman, Phillip A.;
Tharnish, Phillip M.;
Otto, Michael J., Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides. Journal of Medicinal Chemistry 2005, 48(18), 5869 - 5873, 10.1021/jm050335x .
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Naus, Petr;
Hocek, Michal;
Votruba, Ivan;
Pohl, Radek;
Mackman, Richard;
Dzubak, Petr;
Hajduch, Marian;
Ameral, Ria;
Birkus, Gabriel;
Wang, Ting;
Ray, Adrian S.;
Cihlar, Tomas, 6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents. Journal of Medicinal Chemistry 2010, 53(1), 460 - 470, 10.1021/jm901428k .
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Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik, Synthesis of 2'-aminomethyl derivatives of N-(2- (phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents. Journal of Medicinal Chemistry 1996, 39(17), 3263 - 3268, 10.1021/jm9601314 .
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Budesinsky, Milos;
Holy, Antonin;
Jindrich, Jindrich;
Dvorakova, Hana;
Masojidkova, Milena;
Balzarini, Jan;
De Clercq, Erik;
Andrei, Graciella, Acyclic nucleotide analogs derived from 8-azapurines: Synthesis and antiviral activity. Journal of Medicinal Chemistry 1996, 39(20), 4073 - 4088, 10.1021/jm960314q .
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Holy, Antonin;
Dvorakova, Hana;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Guenter, Jaroslav, Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. Journal of Medicinal Chemistry 1999, 42(12), 2064 - 2086, 10.1021/jm9811256 .
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Holy, Antonin;
Votruba, Ivan;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve, 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. Journal of Medicinal Chemistry 2002, 45(9), 1918 - 1929, 10.1021/jm011095y .
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Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Hockova, Dana, 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy) ethoxy]pyrimidines-Acyclic Nucleoside Phosphonate Analogues with Antiviral Activity. Journal of Medicinal Chemistry 2003, 46(23), 5064 - 5073.
Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Naesens, Lieve;
Piskala, Alois;
Neyts, Johan, Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2- (phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry 2007, 50(5), 1069 - 1077, 10.1021/jm061281+ .
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Krecmerova, Marcela;
Holy, Antonin;
Masojidkova, Milena;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Pohl, Radek;
Naesens, Lieve;
Neyts, Johan, Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5- azacytosine: Synthesis and antiviral activity. Journal of Medicinal Chemistry 2007, 50(23), 5765 - 5772, 10.1021/jm0707166 .
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Holy, Antonin;
Jansa, Petr;
Votruba, Ivan;
Masojidkova, Milena;
Tloust'Ova, Eva;
Hrebabecky, Hubert;
Horska, Kveta;
Nencka, Radim, Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. Journal of Medicinal Chemistry 2007, 50(24), 6016 - 6023, 10.1021/jm070644i .
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Holy, Antonin;
Hockova, Dana;
Keough, Dianne T.;
Naesens, Lieve M. J.;
Skinner-Adams, Tina S.;
De Jersey, John;
Guddat, Luke W., Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics. Journal of Medicinal Chemistry 2009, 52(14), 4391 - 4399, 10.1021/jm900267n .
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Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik;
Janeba, Zlatko;
Robins, Morris J., Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides. Journal of Medicinal Chemistry 2005, 48(14), 4690 - 4696, 10.1021/jm050291s .
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Budesinsky, Milos;
Dracinsky, Martin;
Kotora, Martin;
Klepetarova, Blanka;
Eignerova, Barbara;
Slavikova, Barbora;
St'Astna, Eva, Synthesis of fluorinated brassinosteroids based on alkene cross-metathesis and preliminary biological assessment. Journal of Medicinal Chemistry 2009, 52(18), 5753 - 5757, 10.1021/jm900495f .
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Budesinsky, Milos;
Masojidkova, Milena;
Snasel, Jan;
Rosenberg, Ivan;
Pressova, Martina;
Pav, Ondrej;
Protivinska, Eva;
Collinsova, Michaela;
Jiracek, Jiri, Activation of murine RNase L by isopolar 2′-phosphonate analogues of 2′,5′ oligoadenylates. Journal of Medicinal Chemistry 2006, 49(13), 3955 - 3962, 10.1021/jm050401v .
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Budesinsky, Milos;
Rosenberg, Ivan;
Protivinska, Eva;
Collinsova, Michaela;
Jiracek, Jiri;
Netusilova, Hana;
Garrow, Timothy A., S-alkylated homocysteine derivatives: New inhibitors of human betaine-homocysteine S-methyltransferase. Journal of Medicinal Chemistry 2006, 49(13), 3982 - 3989, 10.1021/jm050885v .
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Budesinsky, Milos;
Sanda, Miloslav;
Rosenberg, Ivan;
Brynda, Jiri;
Jiracek, Jiri;
Garrow, Timothy A.;
Vanek, Vaclav;
Kabeleova, Petra;
Kozzisek, Milan;
Hanclova, Ivona;
Mladkova, Jana;
Koutmos, Markos, Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase. Journal of Medicinal Chemistry 2009, 52(12), 3652 - 3665, 10.1021/jm8015798 .
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